Development Level

Tbio 68 | 11,651
Tchem 18 | 1,388
Tdark 4 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 3 | 499
abnormal QT variability 2 | 10
decreased bone mineral density 2 | 126
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retinal vasculature m... 1 | 27
abnormal vocalization 1 | 21
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating glucose ... 1 | 126
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
male infertility 1 | 123
shortened RR interval 1 | 17
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24

Disease

Carcinoma 71 | 11,493
ovarian cancer 52 | 8,520
osteosarcoma 41 | 7,950
lung cancer 40 | 4,740
medulloblastoma, large-cell 36 | 6,241
glioblastoma 35 | 5,792
atypical teratoid / rhabdoid tumor 34 | 5,112
psoriasis 34 | 6,694
group 3 medulloblastoma 33 | 4,104
ependymoma 24 | 4,679
Autosomal recessive predisposition 23 | 1,442
astrocytic glioma 23 | 2,597
non-small cell lung cancer 22 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
adult high grade glioma 21 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
malignant mesothelioma 20 | 3,232
primitive neuroectodermal tumor 19 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
pancreatic cancer 18 | 2,398
invasive ductal carcinoma 17 | 2,951
adrenocortical carcinoma 16 | 1,428
lung adenocarcinoma 16 | 2,716
oligodendroglioma 16 | 2,850
Breast cancer 15 | 3,578
Cancer 15 | 2,499
Kidney cancer 15 | 2,613
Multiple myeloma 15 | 1,332
Pick disease 15 | 1,894
dermatomyositis 15 | 966
Astrocytoma, Pilocytic 14 | 3,081
ductal carcinoma in situ 14 | 1,745
acute quadriplegic myopathy 13 | 1,158
subependymal giant cell astrocytoma 13 | 2,287
Liver Cirrhosis, Experimental 12 | 769
Waldenstrons macroglobulinemia 12 | 765
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Epilepsy 11 | 792
Rheumatoid arthritis 11 | 1,191
breast carcinoma 11 | 1,638
lung carcinoma 11 | 2,843
Glycogen storage disease 10 | 39
Seizures 10 | 596
Hypoglycemia 9 | 152
Liver carcinoma 9 | 240
Obesity 9 | 678
Schizophrenia 9 | 1,160
group 4 medulloblastoma 9 | 1,855
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Global developmental delay 8 | 608
Icterus 8 | 82
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Osteoporosis 8 | 363
Poor school performance 8 | 645
astrocytoma 8 | 1,146
colon cancer 8 | 1,478
tuberculosis 8 | 2,010
ulcerative colitis 8 | 1,819
primary pancreatic ductal adenocarcinoma 7 | 1,109
Adenocarcinoma of lung 6 | 142
Carcinoma, Hepatocellular 6 | 228
Cholecystitis 6 | 18
Cholelithiasis 6 | 33
Congenital hemolytic anemia 6 | 32
Myocardial Ischemia 6 | 169
Splenomegaly 6 | 190
pituitary cancer 6 | 1,972
Alzheimer's disease 5 | 658
Animal Mammary Neoplasms 5 | 136
Atopic dermatitis 5 | 952
Diabetes Mellitus, Experimental 5 | 108
Disease Models, Animal 5 | 155
Gout 5 | 104
Hepatomegaly 5 | 285
Mammary Neoplasms, Animal 5 | 136
Mammary Neoplasms, Experimental 5 | 154
Stomach Neoplasms 5 | 300
active ulcerative colitis 5 | 764
juvenile dermatomyositis 5 | 1,187
nephrosclerosis 5 | 333
pediatric high grade glioma 5 | 1,064
Anemia 4 | 365
Bipolar Disorder 4 | 666
Duchenne muscular dystrophy 4 | 601
Failure to gain weight 4 | 365
Mouth Neoplasms 4 | 55
Pediatric failure to thrive 4 | 365
Type 2 diabetes mellitus 4 | 272
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
medulloblastoma 4 | 720
spina bifida 4 | 1,074

Tissue

Endocrine System 88 | 18,159
Male tissues 87 | 17,142
Digestive Tract 86 | 17,369
Liver and Pancreas 86 | 16,750
Blood and immune system 85 | 16,909
Female tissues 85 | 17,400
Nervous System 85 | 16,725
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678
Cardiovascular System 83 | 15,192
Respiratory system 82 | 16,393

Target Family

Enzyme 36 | 4,145
Non-IDG 26 | 12,091
Kinase 20 | 634
Transporter 8 | 473

Reactome Pathway

Glucose metabolism 90 | 90
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fructose-1,6-bisphosphatase isozyme 2 FBP2 Tbio Enzyme -2.05630 110.1 144
Mitochondrial dicarboxylate carrier SLC25A10 Tbio Transporter -1.25522 17.2 72
Aspartate aminotransferase, mitochondrial GOT2 Tbio Enzyme -3.23630 1435.0 450
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -1.04073 10.5 78
Triosephosphate isomerase TPI1 Tbio Enzyme -2.88127 742.8 315
Nucleoporin Nup37 NUP37 Tdark Non-IDG -0.69307 4.98 70
Nuclear pore complex protein Nup153 NUP153 Tbio Non-IDG -2.14396 129.9 100
Glucose-6-phosphate exchanger SLC37A1 SLC37A1 Tbio Transporter -0.65268 3.88 54
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS Tbio Enzyme -1.79464 54.0 151