Development Level

Tbio 28 | 11,445
Tchem 9 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased total body fat amoun... 2 | 207
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
absent pinna reflex 1 | 23
anophthalmia 1 | 33
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
hypoactivity 1 | 132
increased body length 1 | 32
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26

Disease

Carcinoma 29 | 11,493
ovarian cancer 19 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
osteosarcoma 18 | 7,950
lung cancer 17 | 4,740
medulloblastoma, large-cell 16 | 6,241
Autosomal recessive predisposition 14 | 1,442
psoriasis 14 | 6,694
atypical teratoid / rhabdoid tumor 12 | 5,112
ductal carcinoma in situ 12 | 1,745
glioblastoma 12 | 5,792
invasive ductal carcinoma 12 | 2,951
group 3 medulloblastoma 11 | 4,104
Liver Cirrhosis, Experimental 10 | 769
Multiple myeloma 10 | 1,332
breast carcinoma 9 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Breast cancer 8 | 3,578
Cancer 8 | 2,499
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
primitive neuroectodermal tumor 8 | 3,035
ulcerative colitis 8 | 1,819
Epilepsy 7 | 792
Muscle hypotonia 7 | 571
Pick disease 7 | 1,894
adult high grade glioma 7 | 3,801
astrocytic glioma 7 | 2,597
colon cancer 7 | 1,478
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
Acidosis, Lactic 6 | 97
Kidney cancer 6 | 2,613
Seizures 6 | 596
adrenocortical carcinoma 6 | 1,428
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
Dull intelligence 5 | 645
Intellectual disability 5 | 1,016
Lactic acidemia 5 | 95
Lactic acidosis 5 | 51
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Obesity 5 | 678
Poor school performance 5 | 645
Schizophrenia 5 | 1,160
Succinic semialdehyde dehydrogenase deficiency 5 | 16
fibroadenoma 5 | 559
pancreatic cancer 5 | 2,398
Astrocytoma, Pilocytic 4 | 3,081
Bipolar Disorder 4 | 666
Carcinoma, Hepatocellular 4 | 228
Hypoglycemia 4 | 152
Increased serum lactate 4 | 60
Leigh disease 4 | 100
Liver carcinoma 4 | 240
Pyruvate decarboxylase deficiency 4 | 16
Small head 4 | 374
Waldenstrons macroglobulinemia 4 | 765
acute myeloid leukemia 4 | 783
dermatomyositis 4 | 966
lung carcinoma 4 | 2,843
oligodendroglioma 4 | 2,850
Atopic dermatitis 3 | 952
Biotin deficiency 3 | 10
Cerebral atrophy 3 | 178
Degenerative brain disorder 3 | 100
Increased serum pyruvate 3 | 9
Infantile onset 3 | 238
Liver Failure 3 | 73
Myocardial Infarction 3 | 151
Prostatic Neoplasms 3 | 495
Supratentorial atrophy 3 | 94
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
group 4 medulloblastoma 3 | 1,855
nephrosclerosis 3 | 333
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
Alzheimer's disease 2 | 658
Anteverted nostril 2 | 191
Cholestasis 2 | 155
Endometrial cancer 2 | 311
Hepatomegaly 2 | 285
Hypertension 2 | 396
Infertility, Male 2 | 46
Kidney disease 2 | 430
Male infertility 2 | 206
Mental Depression 2 | 333
Myocardial Ischemia 2 | 169
Status Epilepticus 2 | 98
active ulcerative colitis 2 | 764
cystic fibrosis 2 | 1,696
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064

Tissue

Endocrine System 39 | 18,159
Digestive Tract 38 | 17,369
Liver and Pancreas 38 | 16,750
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678
Blood and immune system 37 | 16,909
Female tissues 37 | 17,400
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Cardiovascular System 34 | 15,192
Respiratory system 34 | 16,393

Target Family

Enzyme 32 | 4,145
Kinase 4 | 634
Non-IDG 3 | 12,091

KEGG Pathway

Pyruvate metabolism 39 | 39
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Acylphosphatase-2 ACYP2 Tbio Enzyme -1.40802 25.6 62
Fumarate hydratase, mitochondrial FH Tbio Enzyme -2.42296 251.7 363
Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Tchem Enzyme -1.85518 70.4 397
L-lactate dehydrogenase B chain LDHB Tchem Enzyme -2.50076 306.0 241
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1 Tbio Enzyme -2.31887 204.2 436
Dihydrolipoyl dehydrogenase, mitochondrial DLD Tbio Enzyme -2.58834 373.1 282
Lactoylglutathione lyase GLO1 Tchem Enzyme -2.54547 366.2 302
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial PCK2 Tbio Kinase -2.28053 174.2 179
Aldehyde dehydrogenase, mitochondrial ALDH2 Tclin Enzyme -2.97865 1004.9 470