Development Level

Tbio 5,873 | 11,651
Tdark 1,507 | 6,593
Tchem 756 | 1,388
Tclin 266 | 612

Collection

RFA-RM-18-021 89 | 328
Kinase: IDG Consortium (Target... 62 | 125
Ion Channel: IDG Consortium (T... 23 | 99
Kinase: IDG Consortium (Comple... 18 | 37
GPCR: IDG Consortium (Complete... 5 | 25
GPCR: IDG Consortium (Targets) 4 | 126

IMPC Phenotype

preweaning lethality, complete... 638 | 979
preweaning lethality, incomple... 263 | 499
embryonic lethality prior to t... 173 | 278
embryonic lethality prior to o... 167 | 239
abnormal behavior 142 | 298
abnormal embryo size 130 | 220
decreased total body fat amoun... 107 | 207
abnormal bone structure 101 | 187
decreased body weight 95 | 161
enlarged heart 83 | 210
increased lean body mass 80 | 172
decreased bone mineral content 77 | 151
decreased vertical activity 75 | 208
increased circulating alkaline... 74 | 122
hyperactivity 72 | 148
decreased bone mineral density 68 | 126
embryonic growth retardation 68 | 106
increased startle reflex 67 | 112
decreased circulating glucose ... 66 | 126
abnormal heart morphology 65 | 162
hypoactivity 64 | 132
increased total body fat amoun... 60 | 134
male infertility 58 | 123
abnormal seminal vesicle morph... 57 | 114
decreased lean body mass 57 | 135
decreased mean corpuscular vol... 55 | 79
increased bone mineral content 54 | 108
prenatal lethality prior to he... 53 | 87
decreased circulating choleste... 52 | 93
decreased grip strength 52 | 116
increased mean corpuscular vol... 52 | 92
increased mean corpuscular hem... 51 | 96
abnormal lens morphology 49 | 81
decreased body length 49 | 101
increased or absent threshold ... 49 | 101
short tibia 49 | 97
cataract 48 | 92
abnormal retina morphology 46 | 71
decreased circulating serum al... 46 | 82
decreased leukocyte cell numbe... 43 | 73
decreased lymphocyte cell numb... 42 | 83
increased fasted circulating g... 42 | 76
decreased circulating HDL chol... 41 | 68
decreased circulating triglyce... 40 | 79
increased bone mineral density 40 | 72
decreased prepulse inhibition 38 | 82
increased circulating choleste... 38 | 66
decreased circulating insulin ... 37 | 76
increased heart weight 37 | 62
abnormal behavioral response t... 35 | 66
edema 35 | 59
increased circulating HDL chol... 35 | 80
decreased erythrocyte cell num... 34 | 62
decreased startle reflex 34 | 75
abnormal coat-hair pigmentatio... 33 | 64
decreased fasted circulating g... 33 | 65
decreased hemoglobin content 33 | 68
decreased mean corpuscular hem... 33 | 50
impaired glucose tolerance 33 | 75
abnormal gait 32 | 69
decreased caudal vertebrae num... 32 | 53
improved glucose tolerance 32 | 79
small superior vagus ganglion 32 | 74
thrombocytopenia 32 | 56
increased circulating sodium l... 30 | 71
increased mean platelet volume 30 | 45
increased monocyte cell number 30 | 63
small testis 30 | 58
abnormal kidney morphology 29 | 65
abnormal sleep behavior 29 | 70
decreased circulating alkaline... 29 | 46
female infertility 29 | 60
abnormal eye morphology 28 | 68
decreased circulating alanine ... 28 | 47
decreased circulating total pr... 28 | 49
increased hematocrit 28 | 46
decreased neutrophil cell numb... 27 | 42
cardiovascular system phenotyp... 26 | 36
decreased circulating LDL chol... 26 | 38
increased leukocyte cell numbe... 26 | 47
abnormal spleen morphology 25 | 55
increased hemoglobin content 25 | 45
abnormal bone mineralization 24 | 38
abnormal neural tube closure 24 | 46
abnormal skin morphology 24 | 50
hydrometra 24 | 53
decreased blood urea nitrogen ... 23 | 51
decreased circulating aspartat... 23 | 34
decreased hematocrit 23 | 46
increased blood urea nitrogen ... 23 | 48
increased erythrocyte cell num... 23 | 39
increased grip strength 23 | 41
increased neutrophil cell numb... 23 | 46
pallor 23 | 34
prolonged QT interval 23 | 38
increased circulating chloride... 22 | 41
tremors 22 | 39
decreased mean corpuscular hem... 21 | 31
prolonged ST segment 21 | 36
decreased circulating fructosa... 20 | 30

Disease

Carcinoma 5,351 | 11,493
ovarian cancer 4,778 | 8,520
osteosarcoma 3,965 | 7,950
psoriasis 3,109 | 6,694
medulloblastoma, large-cell 3,056 | 6,241
glioblastoma 2,934 | 5,792
lung cancer 2,563 | 4,740
atypical teratoid / rhabdoid tumor 2,512 | 5,112
ependymoma 2,212 | 4,679
group 3 medulloblastoma 2,040 | 4,104
Breast cancer 1,836 | 3,578
adult high grade glioma 1,756 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,714 | 3,291
malignant mesothelioma 1,653 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,522 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,471 | 2,955
invasive ductal carcinoma 1,456 | 2,951
Kidney cancer 1,448 | 2,613
primitive neuroectodermal tumor 1,448 | 3,035
Astrocytoma, Pilocytic 1,421 | 3,081
oligodendroglioma 1,418 | 2,850
non-small cell lung cancer 1,396 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 1,316 | 1,962
astrocytic glioma 1,290 | 2,597
lung adenocarcinoma 1,284 | 2,716
Cancer 1,259 | 2,499
pancreatic cancer 1,244 | 2,398
lung carcinoma 1,234 | 2,843
subependymal giant cell astrocytoma 1,138 | 2,287
Pick disease 1,029 | 1,894
Multiple myeloma 1,023 | 1,332
tuberculosis 978 | 2,010
interstitial cystitis 927 | 2,312
group 4 medulloblastoma 924 | 1,855
Autosomal recessive predisposition 877 | 1,442
ulcerative colitis 863 | 1,819
diabetes mellitus 859 | 1,728
ductal carcinoma in situ 834 | 1,745
breast carcinoma 833 | 1,638
pituitary cancer 831 | 1,972
colon cancer 767 | 1,478
acute quadriplegic myopathy 756 | 1,158
cystic fibrosis 756 | 1,696
juvenile dermatomyositis 730 | 1,187
adrenocortical carcinoma 700 | 1,428
astrocytoma 691 | 1,146
dermatomyositis 670 | 966
Rheumatoid arthritis 609 | 1,191
Intellectual disability 603 | 1,016
primary pancreatic ductal adenocarcinoma 595 | 1,109
Waldenstrons macroglobulinemia 580 | 765
pediatric high grade glioma 578 | 1,064
Schizophrenia 547 | 1,160
spina bifida 500 | 1,074
non primary Sjogren syndrome sicca 480 | 891
nasopharyngeal carcinoma 472 | 1,058
Epilepsy 468 | 792
acute myeloid leukemia 451 | 783
cutaneous lupus erythematosus 446 | 1,057
active Crohn's disease 440 | 922
Liver Cirrhosis, Experimental 437 | 769
Atopic dermatitis 428 | 952
Cognitive delay 407 | 608
Global developmental delay 407 | 608
Mental and motor retardation 407 | 608
gastric carcinoma 403 | 807
Dull intelligence 395 | 645
Low intelligence 395 | 645
Mental Retardation 395 | 645
Mental deficiency 395 | 645
Poor school performance 395 | 645
esophageal adenocarcinoma 391 | 737
Muscle hypotonia 385 | 571
progressive supranuclear palsy 381 | 676
Seizures 379 | 596
primary Sjogren syndrome 375 | 735
Duchenne muscular dystrophy 373 | 601
Alzheimer's disease 358 | 658
aldosterone-producing adenoma 347 | 665
Liver cancer 346 | 604
active ulcerative colitis 345 | 764
medulloblastoma 343 | 720
Melanoma 330 | 711
Short stature 321 | 531
pancreatic carcinoma 312 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 309 | 510
Obesity 297 | 678
hepatocellular carcinoma 286 | 547
Down syndrome 285 | 499
Prostatic Neoplasms 280 | 495
Bipolar Disorder 279 | 666
Neurodegenerative disease 270 | 414
Amyotrophic lateral sclerosis 269 | 451
Breast Neoplasms 248 | 445
Small head 248 | 374
Endometriosis 245 | 540
fibroadenoma 245 | 559
gastric cancer 245 | 459
Failure to gain weight 239 | 365
sonic hedgehog group medulloblastoma 239 | 467

Tissue

Endocrine System 8,273 | 18,159
Digestive Tract 8,161 | 17,369
Female tissues 8,158 | 17,400
Skin and soft tissues 8,141 | 17,230
Male tissues 8,086 | 17,142
Blood and immune system 8,061 | 16,909
Liver and Pancreas 8,046 | 16,750
Urinary Tract 8,021 | 16,678
Nervous System 8,005 | 16,725
Respiratory system 7,931 | 16,393
Cardiovascular System 7,668 | 15,192

Target Family

Non-IDG 4,842 | 12,091
Enzyme 2,310 | 4,145
Transcription Factor 399 | 1,400
Kinase 392 | 634
Transporter 188 | 473
Epigenetic 125 | 242
Ion Channel 80 | 344
GPCR 30 | 408
TF/Epigenetic 14 | 38
oGPCR 12 | 421
Nuclear Receptor 10 | 48

HPM Tissue

Fetal Liver 8,402 | 8,402
Adult Testis 10,836 | 10,836
Adult Ovary 10,192 | 10,192
Adult Retina 10,115 | 10,115
CD8 Cells 9,840 | 9,840
Fetal Heart 9,228 | 9,228
Adult Pancreas 9,168 | 9,168
Fetal Ovary 9,118 | 9,118
Adult Liver 9,113 | 9,113
B Cells 9,086 | 9,086
Adult Frontal Cortex 9,048 | 9,048
Adult Prostate 8,952 | 8,952
Fetal Gut 8,640 | 8,640
Adult Adrenal 8,475 | 8,475
NK Cells 8,475 | 8,475
Adult Rectum 8,022 | 8,022
Fetal Testis 7,955 | 7,955
Adult Colon 7,915 | 7,915
Fetal Brain 7,866 | 7,866
CD4 Cells 7,773 | 7,773
Adult Gallbladder 7,612 | 7,612
Adult Spinal Cord 7,594 | 7,594
Adult Urinary Bladder 7,592 | 7,592
Monocytes 7,422 | 7,422
Adult Kidney 6,723 | 6,723
Adult Lung 6,663 | 6,663
Adult Heart 6,506 | 6,506
Platelets 6,131 | 6,131
Placenta 6,083 | 6,083
Adult Esophagus 4,936 | 4,936

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
Protein disulfide-isomerase TMX3 TMX3 Tbio Enzyme -0.72922 5.29 80
RanBP2-like and GRIP domain-containing protein 3 RGPD3 Tdark Non-IDG 0.00000 0