Development Level

Tbio 25 | 11,445
Tchem 3 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal gait 2 | 69
decreased bone mineral content 2 | 151
decreased heart left ventricle... 2 | 28
enlarged heart 2 | 210
increased lymphocyte cell numb... 2 | 32
increased neutrophil cell numb... 2 | 46
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased leukocyte cell numbe... 1 | 47
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 20 | 11,493
Cancer 19 | 2,499
osteosarcoma 17 | 7,950
ovarian cancer 15 | 8,520
psoriasis 15 | 6,694
tuberculosis 13 | 2,010
lung cancer 12 | 4,740
Multiple Sclerosis 10 | 540
Rheumatoid arthritis 10 | 1,191
glioblastoma 10 | 5,792
Astrocytoma, Pilocytic 8 | 3,081
adult high grade glioma 8 | 3,801
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
cystic fibrosis 7 | 1,696
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
medulloblastoma, large-cell 7 | 6,241
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819
Arthritis, Rheumatoid 6 | 174
Asthma 6 | 385
Hypersensitivity reaction type II disease 6 | 253
atypical teratoid / rhabdoid tumor 6 | 5,112
lung carcinoma 6 | 2,843
primary Sjogren syndrome 6 | 735
Autosomal recessive predisposition 5 | 1,442
Influenza 5 | 142
Liver carcinoma 5 | 240
Splenomegaly 5 | 190
cutaneous lupus erythematosus 5 | 1,057
ependymoma 5 | 4,679
non-small cell lung cancer 5 | 2,890
Arthritis 4 | 290
Atherosclerosis 4 | 291
Brain Injuries 4 | 65
Bronchiectasis 4 | 64
Carcinoma, Hepatocellular 4 | 228
Colorectal Neoplasms 4 | 243
Coronary artery disease 4 | 268
Diarrhea 4 | 253
Hepatomegaly 4 | 285
Inflammatory bowel disease 4 | 151
Kidney disease 4 | 430
Leprosy 4 | 73
Melanoma 4 | 711
Neoplasm Metastasis 4 | 168
Osteoporosis 4 | 363
Pneumonia 4 | 174
Schizophrenia 4 | 1,160
Stomach Neoplasms 4 | 300
Systemic lupus erythematosus 4 | 194
Thrombocytopenia 4 | 197
Vascular disease 4 | 319
Vasculitis 4 | 80
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
diabetes mellitus 4 | 1,728
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
nasopharyngeal carcinoma 4 | 1,058
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
sarcoidosis 4 | 370
Abortion, Spontaneous 3 | 109
Acquired immunodeficiency syndrome 3 | 197
Allergic hypersensitivity disease 3 | 126
Anemia 3 | 365
Atopic dermatitis 3 | 952
Breast Neoplasms 3 | 445
Breast cancer 3 | 3,578
Candidiasis 3 | 55
Cerebrovascular disease 3 | 238
Crohn's disease 3 | 321
Dermatitis 3 | 157
Hepatitis C 3 | 94
Hypertension 3 | 396
Immunologic Deficiency Syndromes 3 | 113
Kidney cancer 3 | 2,613
Leukopenia 3 | 72
Liver Cirrhosis 3 | 181
Lung Neoplasms 3 | 232
Lung disease 3 | 142
Lymphadenopathy 3 | 62
Malaria 3 | 160
Mammary Neoplasms 3 | 425
Multiple myeloma 3 | 1,332
Myocardial Infarction 3 | 151
Neuropathy 3 | 261
Otitis Media 3 | 52
Prostatic Neoplasms 3 | 495
Spontaneous abortion 3 | 113
Urticaria 3 | 67
inflammatory breast cancer 3 | 286
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
juvenile dermatomyositis 3 | 1,187
mucosa-associated lymphoid tissue lymphoma 3 | 484
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
periodontitis 3 | 293

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Respiratory system 31 | 16,393
Urinary Tract 31 | 16,678
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Skin and soft tissues 30 | 17,230
Nervous System 27 | 16,725
Cardiovascular System 25 | 15,192

Target Family

Non-IDG 28 | 12,091
Enzyme 2 | 4,145
Transcription Factor 1 | 1,400

GO Function

tumor necrosis factor receptor... 31 | 31
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 1 TRAF1 Tbio Non-IDG -2.13105 138.7 258