Development Level

Tbio 132 | 11,651
Tdark 13 | 6,593
Tclin 4 | 612
Tchem 2 | 1,388

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 5 | 298
increased or absent threshold ... 5 | 101
preweaning lethality, incomple... 5 | 499
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
absent pinna reflex 3 | 23
decreased body weight 3 | 161
decreased circulating amylase ... 3 | 28
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
increased circulating sodium l... 3 | 71
increased total body fat amoun... 3 | 134
abnormal eye morphology 2 | 68
abnormal placenta size 2 | 20
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
stereotypic behavior 2 | 3
trunk curl 2 | 16
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent startle reflex 1 | 24
absent teeth 1 | 3
convulsive seizures 1 | 13
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
edema 1 | 59
enlarged spleen 1 | 41
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased vertical activity 1 | 24
limb grasping 1 | 41
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small thymus 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 125 | 11,493
ovarian cancer 78 | 8,520
osteosarcoma 73 | 7,950
glioblastoma 66 | 5,792
psoriasis 64 | 6,694
medulloblastoma, large-cell 61 | 6,241
atypical teratoid / rhabdoid tumor 57 | 5,112
Kidney cancer 54 | 2,613
ependymoma 54 | 4,679
lung cancer 47 | 4,740
Astrocytoma, Pilocytic 43 | 3,081
Breast cancer 42 | 3,578
pancreatic cancer 42 | 2,398
adult high grade glioma 41 | 3,801
group 3 medulloblastoma 41 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
invasive ductal carcinoma 40 | 2,951
lung carcinoma 40 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
malignant mesothelioma 36 | 3,232
oligodendroglioma 34 | 2,850
primitive neuroectodermal tumor 33 | 3,035
lung adenocarcinoma 31 | 2,716
non-small cell lung cancer 30 | 2,890
acute quadriplegic myopathy 28 | 1,158
interstitial cystitis 27 | 2,312
astrocytic glioma 26 | 2,597
spina bifida 26 | 1,074
colon cancer 25 | 1,478
ductal carcinoma in situ 25 | 1,745
tuberculosis 25 | 2,010
subependymal giant cell astrocytoma 24 | 2,287
Autosomal recessive predisposition 23 | 1,442
Duchenne muscular dystrophy 22 | 601
breast carcinoma 22 | 1,638
group 4 medulloblastoma 21 | 1,855
pituitary cancer 21 | 1,972
primary pancreatic ductal adenocarcinoma 21 | 1,109
ulcerative colitis 21 | 1,819
adrenocortical carcinoma 20 | 1,428
Cancer 19 | 2,499
Melanoma 19 | 711
Pick disease 18 | 1,894
Skin cancer 18 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 510
juvenile dermatomyositis 18 | 1,187
Liver cancer 17 | 604
diabetes mellitus 17 | 1,728
pediatric high grade glioma 17 | 1,064
astrocytoma 16 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Cardiomyopathy 14 | 116
Liver Cirrhosis, Experimental 14 | 769
cystic fibrosis 14 | 1,696
Endometrial cancer 13 | 311
Schizophrenia 13 | 1,160
Distal arthrogryposis 12 | 42
Hypertrophic Cardiomyopathy 12 | 117
Rheumatoid arthritis 12 | 1,191
esophageal adenocarcinoma 12 | 737
Cardiomyopathy, Dilated 11 | 83
Dilated cardiomyopathy 11 | 56
cutaneous lupus erythematosus 11 | 1,057
Atopic dermatitis 10 | 952
Becker muscular dystrophy 10 | 191
Familial isolated dilated cardiomyopathy 10 | 41
Intellectual disability 10 | 1,016
LEFT VENTRICULAR NONCOMPACTION 10 10 | 40
LEFT VENTRICULAR NONCOMPACTION 8 10 | 40
Myopathy 10 | 185
fibroadenoma 10 | 559
gastric carcinoma 10 | 807
pancreatic carcinoma 10 | 562
progressive supranuclear palsy 10 | 676
Amyotrophic lateral sclerosis 9 | 451
Down syndrome 9 | 499
Multiple myeloma 9 | 1,332
acute myeloid leukemia 9 | 783
dermatomyositis 9 | 966
limb girdle muscular dystrophy 2A 9 | 213
nasopharyngeal carcinoma 9 | 1,058
Alzheimer's disease 8 | 658
Bipolar Disorder 8 | 666
Blepharoptosis 8 | 231
Dull intelligence 8 | 645
Hypertension 8 | 396
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Nonsyndromic deafness 8 | 142
Poor school performance 8 | 645
Proximal muscle weakness 8 | 47
Proximal neurogenic muscle weakness 8 | 47
active ulcerative colitis 8 | 764
aldosterone-producing adenoma 8 | 665
medulloblastoma 8 | 720
Byzanthine arch palate 7 | 194
Chronic Lymphocytic Leukemia 7 | 262
Curvature of spine 7 | 282

Tissue

Endocrine System 151 | 18,159
Skin and soft tissues 150 | 17,230
Digestive Tract 148 | 17,369
Female tissues 147 | 17,400
Male tissues 147 | 17,142
Liver and Pancreas 146 | 16,750
Blood and immune system 145 | 16,909
Urinary Tract 142 | 16,678
Nervous System 141 | 16,725
Respiratory system 141 | 16,393
Cardiovascular System 138 | 15,192

Target Family

Non-IDG 136 | 12,091
Enzyme 5 | 4,145
Kinase 4 | 634
Ion Channel 3 | 344
Transcription Factor 2 | 1,400
Transporter 1 | 473

GO Function

actin filament binding 151 | 151
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Villin-like protein VILL Tbio Non-IDG -1.29743 18.2 79
Troponin C, skeletal muscle TNNC2 Tbio Non-IDG -0.85050 6.68 102
CapZ-interacting protein RCSD1 Tbio Non-IDG -0.82900 6.97 62
Myosin-7B MYH7B Tbio Non-IDG -1.18655 12.1 17
Beta-adducin ADD2 Tbio Enzyme -2.01804 106.5 147
Alpha-actinin-2 ACTN2 Tbio Non-IDG -1.89804 72.9 245
Tropomyosin alpha-1 chain TPM1 Tbio Non-IDG -2.19537 154.3 227
F-actin-capping protein subunit beta CAPZB Tbio Non-IDG -1.28214 20.2 226
Plastin-2 LCP1 Tbio Non-IDG -2.22829 176.7 267
Plastin-3 PLS3 Tbio Non-IDG -1.86303 77.6 132