Development Level

Tbio 852 | 10,625
Tchem 398 | 1,890
Tclin 277 | 602
Tdark 196 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 57 | 145
Eligible Ion Channel Proteins 56 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 45 | 633
preweaning lethality, incomple... 27 | 260
abnormal behavior 23 | 226
decreased total body fat amoun... 17 | 186
increased circulating alkaline... 17 | 119
decreased body weight 15 | 174
decreased lean body mass 15 | 195
decreased grip strength 14 | 123
decreased bone mineral content 13 | 157
embryonic lethality prior to t... 13 | 187
enlarged heart 13 | 111
abnormal bone structure 12 | 131
decreased bone mineral density 12 | 126
decreased circulating choleste... 10 | 85
hyperactivity 10 | 108
increased grip strength 10 | 83
increased lean body mass 10 | 107
decreased circulating triglyce... 9 | 83
hypoactivity 9 | 89
increased mean corpuscular vol... 9 | 91
tremors 9 | 34
abnormal epididymis morphology 8 | 31
decreased circulating insulin ... 8 | 75
decreased fasted circulating g... 8 | 49
embryonic lethality prior to o... 8 | 148
enlarged epididymis 8 | 27
impaired glucose tolerance 8 | 52
increased body weight 8 | 42
increased bone mineral content 8 | 92
increased circulating HDL chol... 8 | 63
increased circulating sodium l... 8 | 71
increased mean corpuscular hem... 8 | 93
short tibia 8 | 82
abnormal embryo size 7 | 112
abnormal heart morphology 7 | 51
abnormal retina morphology 7 | 100
cardiovascular system phenotyp... 7 | 35
decreased circulating HDL chol... 7 | 77
decreased circulating alanine ... 7 | 53
decreased circulating alkaline... 7 | 41
improved glucose tolerance 7 | 56
increased or absent threshold ... 7 | 128
thrombocytopenia 7 | 46
decreased heart weight 6 | 44
decreased lumbar vertebrae num... 6 | 62
decreased prepulse inhibition 6 | 52
decreased rib number 6 | 59
limb grasping 6 | 35
abnormal bone mineralization 5 | 55
abnormal gait 5 | 51
abnormal retinal pigmentation 5 | 61
abnormal sleep behavior 5 | 63
decreased T cell number 5 | 31
decreased body length 5 | 108
decreased circulating calcium ... 5 | 33
decreased circulating creatini... 5 | 31
decreased circulating glucose ... 5 | 121
decreased circulating serum al... 5 | 79
increased blood urea nitrogen ... 5 | 44
increased circulating choleste... 5 | 53
increased circulating potassiu... 5 | 31
increased exploration in new e... 5 | 56
increased fasted circulating g... 5 | 68
small superior vagus ganglion 5 | 20
abnormal behavioral response t... 4 | 52
abnormal eye morphology 4 | 38
abnormal lens morphology 4 | 73
abnormal locomotor activation 4 | 26
abnormal seminal vesicle morph... 4 | 47
abnormal skin morphology 4 | 23
abnormal vibrissa morphology 4 | 17
absent vibrissae 4 | 14
decreased B cell number 4 | 30
decreased CD8-positive, alpha-... 4 | 26
decreased NK T cell number 4 | 28
decreased circulating LDL chol... 4 | 37
decreased circulating amylase ... 4 | 24
decreased circulating free fat... 4 | 39
decreased circulating glycerol... 4 | 19
decreased mean corpuscular vol... 4 | 50
decreased monocyte cell number 4 | 28
enlarged spleen 4 | 26
hydrops fetalis 4 | 22
increased bone mineral density 4 | 52
increased circulating creatini... 4 | 29
increased circulating phosphat... 4 | 24
increased heart weight 4 | 37
increased hematocrit 4 | 36
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
increased sacral vertebrae num... 4 | 62
increased vertical activity 4 | 18
abnormal lung morphology 3 | 15
decreased caudal vertebrae num... 3 | 49
decreased neutrophil cell numb... 3 | 37
increased circulating chloride... 3 | 43
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased erythrocyte cell num... 3 | 26
small testis 3 | 37

Disease

psoriasis 761 | 6,685
osteosarcoma 713 | 7,933
ovarian cancer 685 | 8,492
glioblastoma 598 | 5,572
medulloblastoma, large-cell 586 | 6,234
lung cancer 508 | 4,473
Cancer 487 | 2,346
lung carcinoma 471 | 2,844
atypical teratoid / rhabdoid tumor 435 | 4,369
pilocytic astrocytoma 412 | 3,086
non-small cell lung cancer 371 | 2,798
interstitial cystitis 364 | 2,299
malignant mesothelioma 356 | 3,163
Carcinoma 355 | 2,147
lung adenocarcinoma 355 | 2,714
invasive ductal carcinoma 352 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 337 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 334 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 331 | 2,988
ulcerative colitis 312 | 2,087
Breast cancer 310 | 3,099
pediatric high grade glioma 309 | 2,712
pancreatic cancer 305 | 2,300
oligodendroglioma 302 | 2,849
diabetes mellitus 291 | 1,663
primitive neuroectodermal tumor 284 | 3,031
subependymal giant cell astrocytoma 265 | 2,287
ependymoma 254 | 2,514
pituitary cancer 253 | 1,972
cystic fibrosis 239 | 1,670
adult high grade glioma 235 | 2,148
astrocytic glioma 223 | 2,241
ductal carcinoma in situ 223 | 1,745
tuberculosis 222 | 1,563
colon cancer 205 | 1,475
cutaneous lupus erythematosus 203 | 1,056
group 4 medulloblastoma 197 | 1,875
Rheumatoid Arthritis 192 | 1,171
posterior fossa group A ependymoma 191 | 1,511
breast carcinoma 182 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 172 | 1,795
group 3 medulloblastoma 171 | 2,254
Pick disease 163 | 1,893
Kidney disease 161 | 397
primary pancreatic ductal adenocarcinoma 156 | 1,271
astrocytoma 154 | 1,493
medulloblastoma 154 | 1,524
Multiple Sclerosis 153 | 498
adrenocortical carcinoma 148 | 1,427
Hypersensitivity reaction type II disease 138 | 235
Arthritis 133 | 248
Obesity 131 | 616
sonic hedgehog group medulloblastoma 131 | 1,482
posterior fossa group B ependymoma 129 | 1,530
Schizophrenia 128 | 503
dermatomyositis 122 | 967
Asthma 120 | 349
active Crohn's disease 120 | 918
gastric carcinoma 120 | 832
Epilepsy 118 | 346
Hypertension 117 | 293
primary Sjogren syndrome 115 | 789
nasopharyngeal carcinoma 113 | 1,056
Alzheimer's disease 110 | 644
atypical teratoid/rhabdoid tumor 109 | 1,095
mucosa-associated lymphoid tissue lymphoma 102 | 480
juvenile dermatomyositis 100 | 1,189
Liver disease 98 | 219
Atherosclerosis 96 | 275
Atopic dermatitis 96 | 944
Anemia 95 | 252
esophageal adenocarcinoma 95 | 737
Down syndrome 93 | 548
acute quadriplegic myopathy 90 | 1,157
spina bifida 90 | 1,064
Acquired immunodeficiency syndrome 88 | 164
Duchenne muscular dystrophy 87 | 602
Endometriosis 87 | 535
Heart disease 86 | 279
Prostatic Neoplasms 84 | 471
Mammary Neoplasms 81 | 410
Dermatitis 80 | 141
aldosterone-producing adenoma 80 | 664
Ankylosing spondylitis 79 | 138
Cerebrovascular disease 78 | 231
Parkinson's disease 78 | 364
Vascular disease 78 | 281
Uveitis 77 | 103
Autistic Disorder 76 | 320
Human immunodeficiency virus infectious disease 76 | 129
Multiple myeloma 76 | 1,328
nephrosclerosis 76 | 329
Coronary artery disease 75 | 240
IGA Glomerulonephritis 72 | 454
Hypertensive disease 71 | 193
pancreatic carcinoma 71 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 68 | 499
Inflammatory bowel disease 67 | 142
Juvenile rheumatoid arthritis 67 | 105
non-small cell lung carcinoma 67 | 413

Tissue

Nervous System 1,639 | 18,561
Female tissues 1,638 | 18,647
Urinary Tract 1,636 | 18,444
Digestive Tract 1,632 | 18,473
Endocrine System 1,631 | 18,512
Liver and Pancreas 1,607 | 18,136
Skin and soft tissues 1,607 | 18,115
Cardiovascular System 1,592 | 17,958
Blood and immune system 1,579 | 17,995
Male tissues 1,565 | 17,969
Respiratory system 1,553 | 17,484

Target Family

Non-IDG 738 | 11,969
GPCR 266 | 408
Transporter 242 | 473
Ion Channel 212 | 341
Enzyme 149 | 4,146
Kinase 76 | 634
oGPCR 30 | 421
Transcription Factor 10 | 1,400

Compartment GO Term

Integral component of plasma m... 1,723 | 1,723
cellular_component 18,238 | 18,238
Cell 15,807 | 15,807
Cell part 15,807 | 15,807
Intracellular 13,612 | 13,612
Intracellular part 13,475 | 13,475
Organelle 12,649 | 12,649
membrane-bounded organelle 11,794 | 11,794
Intracellular organelle 11,618 | 11,618
Intracellular membrane-bounded... 10,619 | 10,619
Cytoplasm 10,353 | 10,353
Membrane 8,871 | 8,871
Organelle part 8,169 | 8,169
Intracellular organelle part 8,012 | 8,012
Cytoplasmic part 7,831 | 7,831
Nucleus 7,577 | 7,577
Membrane part 6,469 | 6,469
Cytosol 6,034 | 6,034
Plasma membrane 5,673 | 5,673
Intrinsic component of membran... 5,445 | 5,445
Integral component of membrane 5,315 | 5,315
Macromolecular complex 5,171 | 5,171
Cell periphery 5,146 | 5,146
Nucleoplasm 4,930 | 4,930
Extracellular region 4,607 | 4,607
Protein complex 4,439 | 4,439
Intracellular organelle lumen 4,331 | 4,331
Organelle lumen 4,331 | 4,331
membrane-enclosed lumen 4,331 | 4,331
Extracellular region part 3,874 | 3,874
Intracellular non-membrane-bou... 3,840 | 3,840
non-membrane-bounded organelle 3,839 | 3,839
Nuclear part 3,808 | 3,808
Endomembrane system 3,720 | 3,720
Vesicle 3,667 | 3,667
membrane-bounded vesicle 3,495 | 3,495
Nuclear lumen 3,465 | 3,465
Extracellular organelle 2,850 | 2,850
Extracellular vesicle 2,849 | 2,849
Extracellular exosome 2,829 | 2,829
Organelle membrane 2,592 | 2,592
Plasma membrane part 2,564 | 2,564
Cytoskeleton 2,046 | 2,046
Golgi apparatus 1,946 | 1,946
Endoplasmic reticulum 1,872 | 1,872
Intrinsic component of plasma ... 1,783 | 1,783
Bounding membrane of organelle 1,729 | 1,729
Vesicles 1,625 | 1,625
Cytoskeletal part 1,568 | 1,568
Mitochondrion 1,530 | 1,530
Cell projection 1,425 | 1,425
Extracellular space 1,329 | 1,329
Whole membrane 1,320 | 1,320
GO:0098796 1,304 | 1,304
Cell junction 1,301 | 1,301
Vacuole 1,263 | 1,263
Intracellular vesicle 1,256 | 1,256
Cytoplasmic vesicle 1,255 | 1,255
Catalytic complex 1,234 | 1,234
Endoplasmic reticulum part 1,230 | 1,230
cytoplasmic, membrane-bounded ... 1,125 | 1,125
GO:0031975 1,092 | 1,092
Microtubule cytoskeleton 1,087 | 1,087
Organelle envelope 1,084 | 1,084
Nuclear outer membrane-endopla... 1,079 | 1,079
Endoplasmic reticulum membrane 1,062 | 1,062
Mitochondria 1,003 | 1,003
Chromosome 999 | 999
Mitochondrial part 988 | 988
Nucleoli 950 | 950
Golgi apparatus part 940 | 940
Neuron part 913 | 913
Chromosomal part 862 | 862
Endosome 857 | 857
Nucleolus 839 | 839
Cell surface 836 | 836
Transferase complex 815 | 815
Ribonucleoprotein complex 794 | 794
Intracellular ribonucleoprotei... 790 | 790
Nucleoplasm part 781 | 781
Plasma membrane region 777 | 777
Vacuolar part 776 | 776
Polymeric cytoskeletal fiber 758 | 758
Supramolecular fiber 758 | 758
Cell projection part 739 | 739
Plasma membrane protein comple... 721 | 721
Mitochondrial envelope 716 | 716
Golgi membrane 710 | 710
Anchoring junction 702 | 702
Adherens junction 687 | 687
Cytoplasmic vesicle part 682 | 682
Neuron projection 681 | 681
Microtubule organizing center 680 | 680
Centrosome 676 | 676
Vacuolar membrane 667 | 667
Mitochondrial membrane 663 | 663
Receptor complex 656 | 656
Extracellular matrix 633 | 633
Synapse 594 | 594
Lytic vacuole 571 | 571

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epidermal growth factor receptor EGFR Tclin Kinase -3.98983 9318.1 4989
Nitric oxide synthase, endothelial NOS3 Tchem Enzyme -3.94489 9088.3 1076
Intercellular adhesion molecule 1 ICAM1 Tchem Non-IDG -3.94773 8990.1 1781
Carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM5 Tbio Non-IDG -3.98063 8916.8 1174
Interleukin-4 IL4 Tbio Non-IDG -3.96666 8890.7 1086