Development Level

Tbio 746 | 11,445
Tdark 195 | 6,588
Tchem 119 | 1,598
Tclin 90 | 613

Collection

RFA-RM-18-021 5 | 328
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 99 | 979
preweaning lethality, incomple... 33 | 499
embryonic lethality prior to o... 27 | 239
embryonic lethality prior to t... 26 | 278
abnormal behavior 23 | 298
decreased vertical activity 17 | 208
abnormal embryo size 16 | 220
decreased total body fat amoun... 16 | 207
increased lean body mass 16 | 172
increased total body fat amoun... 16 | 134
decreased body weight 15 | 161
enlarged heart 15 | 210
hyperactivity 14 | 148
decreased bone mineral content 13 | 151
decreased lean body mass 13 | 135
abnormal bone structure 12 | 187
abnormal heart morphology 11 | 162
hypoactivity 11 | 132
cataract 10 | 92
embryonic growth retardation 10 | 106
abnormal lens morphology 9 | 81
increased mean corpuscular hem... 9 | 96
increased startle reflex 9 | 112
male infertility 8 | 123
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating glucose ... 7 | 126
decreased hematocrit 7 | 46
decreased mean corpuscular vol... 7 | 79
increased circulating alkaline... 7 | 122
prenatal lethality prior to he... 7 | 87
abnormal gait 6 | 69
abnormal snout morphology 6 | 23
decreased body length 6 | 101
decreased circulating LDL chol... 6 | 38
decreased circulating alkaline... 6 | 46
decreased circulating choleste... 6 | 93
decreased grip strength 6 | 116
decreased hemoglobin content 6 | 68
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 76
pallor 6 | 34
thrombocytopenia 6 | 56
abnormal neural tube closure 5 | 46
abnormal skin morphology 5 | 50
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased heart weight 5 | 27
decreased lymphocyte cell numb... 5 | 83
edema 5 | 59
impaired glucose tolerance 5 | 75
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased circulating phosphat... 5 | 26
increased heart weight 5 | 62
increased mean corpuscular vol... 5 | 92
increased monocyte cell number 5 | 63
increased red blood cell distr... 5 | 34
short tibia 5 | 97
abnormal coat-hair pigmentatio... 4 | 64
abnormal placenta size 4 | 20
abnormal seminal vesicle morph... 4 | 114
decreased circulating aspartat... 4 | 34
decreased circulating phosphat... 4 | 27
decreased circulating total pr... 4 | 49
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular hem... 4 | 50
decreased total retina thickne... 4 | 17
female infertility 4 | 60
increased circulating calcium ... 4 | 34
increased prepulse inhibition 4 | 32
small superior vagus ganglion 4 | 74
small testis 4 | 58
small thymus 4 | 16
tremors 4 | 39
abnormal bone mineralization 3 | 38
abnormal cranium morphology 3 | 36
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating calcium ... 3 | 36
decreased circulating creatini... 3 | 39
decreased circulating iron lev... 3 | 32
decreased fasted circulating g... 3 | 65
decreased lactate dehydrogenas... 3 | 16
decreased prepulse inhibition 3 | 82
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
increased anti-nuclear antigen... 3 | 19
increased bone mineral density 3 | 72
increased circulating bilirubi... 3 | 16
increased circulating chloride... 3 | 41
increased or absent threshold ... 3 | 101
pale yolk sac 3 | 25
persistence of hyaloid vascula... 3 | 33
prolonged QT interval 3 | 38

Disease

ovarian cancer 629 | 8,520
Carcinoma 587 | 11,493
osteosarcoma 524 | 7,950
medulloblastoma, large-cell 398 | 6,241
psoriasis 382 | 6,694
lung cancer 373 | 4,740
glioblastoma 350 | 5,792
atypical teratoid / rhabdoid tumor 307 | 5,112
ependymoma 267 | 4,679
group 3 medulloblastoma 241 | 4,104
Breast cancer 227 | 3,578
adult high grade glioma 221 | 3,801
pancreatic ductal adenocarcinoma liver metastasis 212 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 211 | 3,291
malignant mesothelioma 208 | 3,232
Cancer 198 | 2,499
Multiple myeloma 188 | 1,332
invasive ductal carcinoma 185 | 2,951
non-small cell lung cancer 179 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 178 | 2,989
astrocytic glioma 167 | 2,597
oligodendroglioma 164 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 160 | 2,955
primitive neuroectodermal tumor 160 | 3,035
lung adenocarcinoma 154 | 2,716
Astrocytoma, Pilocytic 146 | 3,081
Autosomal recessive predisposition 144 | 1,442
pancreatic cancer 131 | 2,398
tuberculosis 130 | 2,010
diabetes mellitus 129 | 1,728
lung carcinoma 128 | 2,843
Pick disease 126 | 1,894
group 4 medulloblastoma 119 | 1,855
subependymal giant cell astrocytoma 116 | 2,287
breast carcinoma 115 | 1,638
ulcerative colitis 109 | 1,819
Schizophrenia 102 | 1,160
ductal carcinoma in situ 100 | 1,745
Kidney cancer 95 | 2,613
colon cancer 94 | 1,478
interstitial cystitis 93 | 2,312
Epilepsy 91 | 792
Rheumatoid arthritis 91 | 1,191
Waldenstrons macroglobulinemia 88 | 765
acute quadriplegic myopathy 87 | 1,158
cystic fibrosis 87 | 1,696
non primary Sjogren syndrome sicca 87 | 891
pituitary cancer 86 | 1,972
Alzheimer's disease 85 | 658
adrenocortical carcinoma 85 | 1,428
dermatomyositis 85 | 966
Cognitive delay 79 | 608
Global developmental delay 79 | 608
Mental and motor retardation 79 | 608
astrocytoma 79 | 1,146
Seizures 78 | 596
acute myeloid leukemia 78 | 783
Neurodegenerative disease 77 | 414
Obesity 75 | 678
Intellectual disability 74 | 1,016
juvenile dermatomyositis 73 | 1,187
Muscle hypotonia 72 | 571
nasopharyngeal carcinoma 70 | 1,058
pediatric high grade glioma 66 | 1,064
Cerebellar Ataxia 65 | 304
Liver Cirrhosis, Experimental 63 | 769
Parkinson's disease 63 | 392
primary pancreatic ductal adenocarcinoma 61 | 1,109
Bipolar Disorder 60 | 666
Mammary Neoplasms 60 | 425
aldosterone-producing adenoma 60 | 665
Breast Neoplasms 59 | 445
Failure to gain weight 59 | 365
Pediatric failure to thrive 59 | 365
Dull intelligence 56 | 645
Low intelligence 56 | 645
Mental Retardation 56 | 645
Mental deficiency 56 | 645
Poor school performance 56 | 645
cutaneous lupus erythematosus 56 | 1,057
Leigh disease 55 | 100
Optic Atrophy 55 | 242
Toxic encephalopathy 54 | 141
Dystonia 53 | 164
Diabetes mellitus type 2 52 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Amyotrophic lateral sclerosis 50 | 451
Depressive disorder 50 | 409
Hyperreflexia 49 | 209
Nystagmus 49 | 317
Vascular disease 49 | 319
Atopic dermatitis 48 | 952
Blepharoptosis 48 | 231
Acidosis, Lactic 47 | 97
Lactic acidemia 47 | 95
Prostatic Neoplasms 46 | 495
Stomach Neoplasms 45 | 300
Neuropathy 44 | 261
hereditary spastic paraplegia 44 | 318
primary Sjogren syndrome 44 | 735

Tissue

Endocrine System 1,125 | 18,159
Digestive Tract 1,115 | 17,369
Female tissues 1,111 | 17,400
Male tissues 1,108 | 17,142
Liver and Pancreas 1,106 | 16,750
Skin and soft tissues 1,106 | 17,230
Blood and immune system 1,102 | 16,909
Nervous System 1,098 | 16,725
Urinary Tract 1,098 | 16,678
Respiratory system 1,088 | 16,393
Cardiovascular System 1,067 | 15,192

Target Family

Non-IDG 592 | 12,091
Enzyme 372 | 4,145
Transporter 71 | 473
Kinase 40 | 634
Transcription Factor 32 | 1,400
Ion Channel 17 | 344
Epigenetic 12 | 242
GPCR 10 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Compartment GO Term

GO:0031975 1,150 | 1,150
cellular_component 18,320 | 18,320
Cell 16,178 | 16,178
Cell part 16,177 | 16,177
Intracellular 14,109 | 14,109
Intracellular part 13,972 | 13,972
Organelle 12,238 | 12,238
Intracellular organelle 12,025 | 12,025
membrane-bounded organelle 11,132 | 11,132
Cytoplasm 10,983 | 10,983
Intracellular membrane-bounded... 10,341 | 10,341
Cytoplasmic part 9,247 | 9,247
Organelle part 8,975 | 8,975
Intracellular organelle part 8,783 | 8,783
Membrane 8,531 | 8,531
Nucleus 7,562 | 7,562
Cytosol 6,686 | 6,686
Membrane part 6,554 | 6,554
Plasma membrane 5,830 | 5,830
Macromolecular complex 5,475 | 5,475
Intrinsic component of membran... 5,458 | 5,458
Cell periphery 5,382 | 5,382
Integral component of membrane 5,331 | 5,331
Intracellular organelle lumen 5,090 | 5,090
Organelle lumen 5,090 | 5,090
membrane-enclosed lumen 5,090 | 5,090
Nucleoplasm 5,077 | 5,077
Nuclear part 4,290 | 4,290
Endomembrane system 4,237 | 4,237
Intracellular non-membrane-bou... 3,975 | 3,975
non-membrane-bounded organelle 3,974 | 3,974
Nuclear lumen 3,968 | 3,968
Protein complex 3,674 | 3,674
Organelle membrane 2,846 | 2,846
Extracellular region 2,732 | 2,732
Plasma membrane part 2,594 | 2,594
Vesicle 2,342 | 2,342
Cytoplasmic vesicle 2,218 | 2,218
Intracellular vesicle 2,217 | 2,217
Cytoskeleton 2,108 | 2,108
Endoplasmic reticulum 2,001 | 2,001
Bounding membrane of organelle 1,956 | 1,956
Golgi apparatus 1,933 | 1,933
Intrinsic component of plasma ... 1,749 | 1,749
Integral component of plasma m... 1,693 | 1,693
Catalytic complex 1,642 | 1,642
Cytoskeletal part 1,637 | 1,637
Extracellular region part 1,628 | 1,628
Vesicles 1,613 | 1,613
Mitochondrion 1,576 | 1,576
Whole membrane 1,548 | 1,548
Cell projection 1,541 | 1,541
Cytoplasmic vesicle part 1,513 | 1,513
Endoplasmic reticulum part 1,359 | 1,359
Organelle envelope 1,142 | 1,142
Microtubule cytoskeleton 1,137 | 1,137
Extracellular space 1,124 | 1,124
Nucleoplasm part 1,122 | 1,122
Nuclear outer membrane-endopla... 1,121 | 1,121
Endoplasmic reticulum membrane 1,103 | 1,103
Chromosome 1,039 | 1,039
Mitochondrial part 1,036 | 1,036
Mitochondria 998 | 998
Secretory vesicle 971 | 971
Neuron part 970 | 970
Supramolecular polymer 967 | 967
Supramolecular complex 966 | 966
Cell junction 960 | 960
Supramolecular fiber 959 | 959
Golgi apparatus part 951 | 951
Nucleoli 942 | 942
Endosome 930 | 930
Nucleolus 926 | 926
Chromosomal part 889 | 889
GO:0098796 884 | 884
Ribonucleoprotein complex 865 | 865
Secretory granule 852 | 852
Cell projection part 850 | 850
Intracellular ribonucleoprotei... 850 | 850
Transferase complex 849 | 849
Cell surface 842 | 842
Plasma membrane region 841 | 841
Vesicle membrane 801 | 801
Cytoplasmic vesicle membrane 795 | 795
Polymeric cytoskeletal fiber 764 | 764
Mitochondrial envelope 746 | 746
Vacuole 732 | 732
Nuclear body 725 | 725
Golgi membrane 724 | 724
Microtubule organizing center 721 | 721
Extracellular matrix 714 | 714
Neuron projection 712 | 712
Centrosome 696 | 696
Mitochondrial membrane 696 | 696
Receptor complex 686 | 686
Synapse 663 | 663
Lysosome 624 | 624
Lytic vacuole 624 | 624
Chromatin 565 | 565
Endosomal part 565 | 565

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier family 25 member 47 SLC25A47 Tbio Transporter 0.03 0.48 83
Nesprin-2 SYNE2 Tbio Non-IDG -2.62747 380.6 39
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Sulfide:quinone oxidoreductase, mitochondrial SQOR Tbio Enzyme -1.15656 14.6 89
Transmembrane protein 14A TMEM14A Tbio Non-IDG -0.33645 3.05 17
Cytochrome c oxidase assembly protein COX11, mitochondrial COX11 Tbio Enzyme -1.42359 24.4 86
Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 Tbio Non-IDG -1.17500 13.6 283
Mitochondrial carrier homolog 2 MTCH2 Tbio Non-IDG -1.67923 50.3 155
Protein misato homolog 1 MSTO1 Tbio Non-IDG -1.77593 58.1 65