Development Level

Tbio 39 | 11,445
Tchem 10 | 1,598
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased circulating glucose ... 1 | 126
decreased granulocyte number 1 | 6
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
enlarged heart 1 | 210
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
increased mean corpuscular hem... 1 | 96
increased vertical activity 1 | 24
short tibia 1 | 97

Disease

ovarian cancer 34 | 8,520
Carcinoma 32 | 11,493
lung cancer 20 | 4,740
osteosarcoma 19 | 7,950
Multiple myeloma 18 | 1,332
psoriasis 17 | 6,694
medulloblastoma, large-cell 15 | 6,241
Cancer 14 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
glioblastoma 13 | 5,792
Breast cancer 12 | 3,578
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
oligodendroglioma 10 | 2,850
acute quadriplegic myopathy 9 | 1,158
atypical teratoid / rhabdoid tumor 8 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
invasive ductal carcinoma 8 | 2,951
lung adenocarcinoma 8 | 2,716
non-small cell lung cancer 8 | 2,890
Leukoencephalopathy with vanishing white matter 7 | 20
Muscle hypotonia 7 | 571
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
Astrocytoma, Pilocytic 6 | 3,081
Autosomal recessive predisposition 6 | 1,442
Dysarthria 6 | 192
Epilepsy 6 | 792
Gait, Unsteady 6 | 29
Seizures 6 | 596
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 3,801
dermatomyositis 6 | 966
Big calvaria 5 | 147
Brain hypomyelination 5 | 11
Breast Neoplasms 5 | 445
Central nervous system demyelination 5 | 28
Cessation of head growth 5 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 6
Decreased serum progesterone 5 | 5
Delusions 5 | 11
Developmental regression 5 | 95
Forgetful 5 | 40
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Kidney cancer 5 | 2,613
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Loss of developmental milestones 5 | 95
Mammary Neoplasms 5 | 425
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental deterioration in childhood 5 | 95
Mood swings 5 | 77
Muscle Spasticity 5 | 195
Neurodevelopmental regression 5 | 95
OVARIOLEUKODYSTROPHY 5 | 6
Optic Atrophy 5 | 242
Personality change 5 | 23
Premature Menopause 5 | 31
Primary gonadal insufficiency 5 | 9
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Secondary physiologic amenorrhea 5 | 32
Vanishing White Matter Leukodystrophy with Ovarian Failure 5 | 5
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
Adenocarcinoma of lung 4 | 142
Amyotrophic lateral sclerosis 4 | 451
HIV Infections 4 | 102
Intellectual disability 4 | 1,016
Neoplasm Metastasis 4 | 168
colon cancer 4 | 1,478
group 4 medulloblastoma 4 | 1,855
hereditary spastic paraplegia 4 | 318
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis 4 | 2,010
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Status Epilepticus 3 | 98
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
ductal carcinoma in situ 3 | 1,745
gastric carcinoma 3 | 807
nasopharyngeal carcinoma 3 | 1,058
sonic hedgehog group medulloblastoma 3 | 467
spina bifida 3 | 1,074
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis and treatment for 6 months 3 | 409
ulcerative colitis 3 | 1,819

Tissue

Blood and immune system 51 | 16,909
Cardiovascular System 51 | 15,192
Digestive Tract 51 | 17,369
Endocrine System 51 | 18,159
Female tissues 51 | 17,400
Liver and Pancreas 51 | 16,750
Male tissues 51 | 17,142
Nervous System 51 | 16,725
Respiratory system 51 | 16,393
Skin and soft tissues 51 | 17,230
Urinary Tract 51 | 16,678

Target Family

Non-IDG 45 | 12,091
Kinase 4 | 634
Enzyme 2 | 4,145

WikiPathways Pathway

Translation Factors 51 | 51
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic translation initiation factor 5B EIF5B Tbio Non-IDG -2.74742 528.3 124
Eukaryotic translation initiation factor 2-alpha kinase 1 EIF2AK1 Tchem Kinase -2.02167 96.7 226
Elongation factor 1-delta EEF1D Tbio Non-IDG -1.49204 29.5 198
Eukaryotic translation initiation factor 4E-binding protein 1 EIF4EBP1 Tbio Non-IDG -2.83637 578.9 1455
Eukaryotic translation initiation factor 4 gamma 3 EIF4G3 Tbio Non-IDG -1.30600 17.8 114
Elongation factor 1-beta EEF1B2 Tbio Non-IDG -1.74379 54.3 110