Development Level

Tbio 81 | 11,445
Tdark 12 | 6,588
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, complete... 19 | 979
cataract 4 | 92
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal seminal vesicle morph... 2 | 114
abnormal tail morphology 2 | 25
decreased circulating choleste... 2 | 93
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged lymph nodes 2 | 37
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal motor learning 1 | 3
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal retinal outer nuclear... 1 | 3
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
corneal opacity 1 | 32
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
edema 1 | 59
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
irregularly shaped pupil 1 | 7
microphthalmia 1 | 26
mydriasis 1 | 6
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

ovarian cancer 65 | 8,520
Carcinoma 59 | 11,493
group 3 medulloblastoma 57 | 4,104
medulloblastoma, large-cell 56 | 6,241
psoriasis 52 | 6,694
lung cancer 49 | 4,740
atypical teratoid / rhabdoid tumor 48 | 5,112
glioblastoma 48 | 5,792
Breast cancer 47 | 3,578
osteosarcoma 45 | 7,950
primitive neuroectodermal tumor 44 | 3,035
non-small cell lung cancer 40 | 2,890
ependymoma 39 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
adrenocortical carcinoma 34 | 1,428
lung adenocarcinoma 32 | 2,716
adult high grade glioma 31 | 3,801
invasive ductal carcinoma 31 | 2,951
malignant mesothelioma 30 | 3,232
ductal carcinoma in situ 24 | 1,745
oligodendroglioma 24 | 2,850
Endometriosis 20 | 540
breast carcinoma 20 | 1,638
colon cancer 20 | 1,478
Atopic dermatitis 19 | 952
Cancer 19 | 2,499
Kidney cancer 19 | 2,613
nasopharyngeal carcinoma 19 | 1,058
pancreatic cancer 18 | 2,398
astrocytic glioma 17 | 2,597
Waldenstrons macroglobulinemia 14 | 765
subependymal giant cell astrocytoma 14 | 2,287
Astrocytoma, Pilocytic 13 | 3,081
Pick disease 13 | 1,894
ulcerative colitis 13 | 1,819
Intellectual disability 12 | 1,016
Multiple myeloma 12 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
dermatomyositis 9 | 966
interstitial cystitis 9 | 2,312
primary Sjogren syndrome 9 | 735
pituitary cancer 8 | 1,972
Small head 7 | 374
acute quadriplegic myopathy 7 | 1,158
astrocytoma 7 | 1,146
group 4 medulloblastoma 7 | 1,855
lung carcinoma 7 | 2,843
tuberculosis 7 | 2,010
Dull intelligence 6 | 645
Hypoplastic mandible condyle 6 | 275
Low intelligence 6 | 645
Mandibular hypoplasia 6 | 275
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Micrognathism 6 | 275
Poor school performance 6 | 645
Short stature 6 | 531
acute myeloid leukemia 6 | 783
progressive supranuclear palsy 6 | 676
Autosomal recessive predisposition 5 | 1,442
Cognitive delay 5 | 608
Glaucoma 5 | 239
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Microcephaly 5 | 166
active Crohn's disease 5 | 922
juvenile dermatomyositis 5 | 1,187
Amyotrophic lateral sclerosis 4 | 451
Cataract 4 | 297
Cerebellar Hypoplasia 4 | 61
Epilepsy 4 | 792
Lens Opacities 4 | 231
Liver cancer 4 | 604
Schizophrenia 4 | 1,160
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis and chronic rhinosinusitis 4 | 214
gastric carcinoma 4 | 807
pancreatic carcinoma 4 | 562
Abnormally small eyeball 3 | 97
Alzheimer's disease 3 | 658
Anteverted nostril 3 | 191
Bipolar Disorder 3 | 666
Congenital Epicanthus 3 | 177
Corneal Opacity 3 | 53
Decreased size of eyeball 3 | 97
Down syndrome 3 | 499
Lissencephaly 3 | 69
Melanoma 3 | 711
Muscular dystrophy 3 | 75
Psychotic Disorders 3 | 151
Rheumatoid arthritis 3 | 1,191
Skin cancer 3 | 469
gastric cancer 3 | 459
hereditary spastic paraplegia 3 | 318
medulloblastoma 3 | 720
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Endocrine System 100 | 18,159
Blood and immune system 98 | 16,909
Digestive Tract 98 | 17,369
Female tissues 98 | 17,400
Male tissues 98 | 17,142
Nervous System 98 | 16,725
Skin and soft tissues 98 | 17,230
Liver and Pancreas 97 | 16,750
Respiratory system 97 | 16,393
Urinary Tract 97 | 16,678
Cardiovascular System 92 | 15,192

Target Family

Non-IDG 84 | 12,091
Kinase 6 | 634
Enzyme 4 | 4,145
Epigenetic 3 | 242
Transcription Factor 3 | 1,400

UniProt Keyword

Kinetochore 100 | 100
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinetochore scaffold 1 KNL1 Tbio Non-IDG -2.20924 151.8 85
Biorientation of chromosomes in cell division protein 1-like 2 BOD1L2 Tdark Non-IDG 0.00000 4
BUB3-interacting and GLEBS motif-containing protein ZNF207 ZNF207 Tbio Non-IDG -0.82146 6.93 264
Spindle and kinetochore-associated protein 1 SKA1 Tbio Non-IDG -1.50228 32.0 58
Centromere-associated protein E CENPE Tchem Non-IDG -2.14817 140.2 166
Centromere protein T CENPT Tbio Non-IDG -1.19511 14.4 69
Meiosis-specific kinetochore protein MEIKIN Tdark Non-IDG 0.00000 3
Nucleoporin Nup37 NUP37 Tdark Non-IDG -0.69307 4.98 70
Kinetochore-associated protein 1 KNTC1 Tbio Non-IDG -2.55470 355.0 105
Centromere protein S CENPS Tbio Non-IDG -2.05081 96.7 62