Development Level

Tbio 361 | 11,445
Tchem 77 | 1,598
Tclin 28 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 34 | 979
preweaning lethality, incomple... 18 | 499
decreased total body fat amoun... 8 | 207
embryonic lethality prior to t... 8 | 278
abnormal behavior 7 | 298
abnormal bone structure 6 | 187
abnormal retina morphology 6 | 71
embryonic lethality prior to o... 6 | 239
abnormal embryo size 5 | 220
decreased startle reflex 5 | 75
hypoactivity 5 | 132
impaired glucose tolerance 5 | 75
increased startle reflex 5 | 112
abnormal lens morphology 4 | 81
decreased vertical activity 4 | 208
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased heart weight 4 | 62
increased leukocyte cell numbe... 4 | 47
increased lymphocyte cell numb... 4 | 32
increased mean corpuscular vol... 4 | 92
male infertility 4 | 123
abnormal eye morphology 3 | 68
abnormal seminal vesicle morph... 3 | 114
cataract 3 | 92
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased mean corpuscular vol... 3 | 79
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
female infertility 3 | 60
increased bone mineral content 3 | 108
increased circulating choleste... 3 | 66
increased neutrophil cell numb... 3 | 46
increased or absent threshold ... 3 | 101
tremors 3 | 39
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal gait 2 | 69
abnormal iris morphology 2 | 13
abnormal maxilla morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
cardiovascular system phenotyp... 2 | 36
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating chloride... 2 | 30
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
enlarged spleen 2 | 41
hemorrhage 2 | 23
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating potassiu... 2 | 29
increased eosinophil cell numb... 2 | 11
increased exploration in new e... 2 | 8
increased fasted circulating g... 2 | 76
increased large unstained cell... 2 | 5
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
abnormal cornea morphology 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prenatal lethality 1 | 28
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 314 | 11,493
ovarian cancer 264 | 8,520
Cancer 252 | 2,499
psoriasis 237 | 6,694
osteosarcoma 214 | 7,950
lung cancer 173 | 4,740
glioblastoma 172 | 5,792
medulloblastoma, large-cell 152 | 6,241
atypical teratoid / rhabdoid tumor 124 | 5,112
diabetes mellitus 118 | 1,728
ependymoma 112 | 4,679
dermatomyositis 108 | 966
Breast cancer 103 | 3,578
group 3 medulloblastoma 102 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 102 | 3,291
adult high grade glioma 95 | 3,801
Multiple myeloma 93 | 1,332
invasive ductal carcinoma 91 | 2,951
malignant mesothelioma 90 | 3,232
Rheumatoid arthritis 88 | 1,191
lung carcinoma 84 | 2,843
Hypersensitivity reaction type II disease 81 | 253
Kidney cancer 81 | 2,613
Astrocytoma, Pilocytic 80 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,989
tuberculosis 80 | 2,010
non-small cell lung cancer 78 | 2,890
Arthritis 77 | 290
Ankylosing spondylitis 73 | 140
Behcet's disease 72 | 89
subependymal giant cell astrocytoma 72 | 2,287
lung adenocarcinoma 71 | 2,716
oligodendroglioma 70 | 2,850
pancreatic cancer 70 | 2,398
Acquired immunodeficiency syndrome 69 | 197
primitive neuroectodermal tumor 67 | 3,035
interstitial cystitis 66 | 2,312
Human immunodeficiency virus infectious disease 65 | 138
juvenile dermatomyositis 64 | 1,187
Juvenile rheumatoid arthritis 60 | 111
Multiple Sclerosis 60 | 540
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,955
ulcerative colitis 60 | 1,819
Stevens-Johnson syndrome 59 | 92
astrocytoma 59 | 1,146
Herpes zoster 58 | 68
Uveitis 58 | 103
Waldenstrons macroglobulinemia 58 | 765
Schizophrenia 54 | 1,160
cutaneous lupus erythematosus 54 | 1,057
astrocytic glioma 53 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 52 | 1,962
Psoriatic arthritis 51 | 86
Pick disease 50 | 1,894
ductal carcinoma in situ 49 | 1,745
primary Sjogren syndrome 49 | 735
acute quadriplegic myopathy 48 | 1,158
colon cancer 47 | 1,478
Kidney disease 45 | 430
Autosomal recessive predisposition 44 | 1,442
cystic fibrosis 44 | 1,696
primary pancreatic ductal adenocarcinoma 44 | 1,109
Dermatitis 42 | 157
breast carcinoma 40 | 1,638
group 4 medulloblastoma 40 | 1,855
Anemia 38 | 365
pediatric high grade glioma 38 | 1,064
Synovitis 37 | 78
adrenocortical carcinoma 37 | 1,428
pituitary cancer 37 | 1,972
Behcet's syndrome 36 | 50
Intellectual disability 36 | 1,016
Liver disease 36 | 237
Nephritis 36 | 51
Takayasu's arteritis 36 | 53
Congenital adrenal hyperplasia 35 | 73
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
drug-induced hepatitis 35 | 44
nasopharyngeal carcinoma 33 | 1,058
Liver Cirrhosis, Experimental 30 | 769
Breast Neoplasms 29 | 445
Dull intelligence 29 | 645
Hepatitis B 29 | 108
Low intelligence 29 | 645
Mental Retardation 29 | 645
Mental deficiency 29 | 645
Poor school performance 29 | 645
esophageal adenocarcinoma 29 | 737
active Crohn's disease 28 | 922
Alzheimer's disease 27 | 658
Atopic dermatitis 27 | 952
Down syndrome 27 | 499
Epilepsy 27 | 792
Mammary Neoplasms 27 | 425
Primary immunodeficiency disease 27 | 54
Skin disease 27 | 66
acute myeloid leukemia 26 | 783
Duchenne muscular dystrophy 25 | 601
Asthma 24 | 385

Tissue

Blood and immune system 403 | 16,909
Endocrine System 403 | 18,159
Female tissues 403 | 17,400
Digestive Tract 402 | 17,369
Liver and Pancreas 402 | 16,750
Skin and soft tissues 402 | 17,230
Urinary Tract 402 | 16,678
Male tissues 401 | 17,142
Nervous System 401 | 16,725
Respiratory system 401 | 16,393
Cardiovascular System 390 | 15,192

Target Family

Non-IDG 322 | 12,091
Enzyme 66 | 4,145
Kinase 30 | 634
Epigenetic 19 | 242
Transcription Factor 18 | 1,400
GPCR 7 | 408
Transporter 7 | 473
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

UniProt Keyword

Host-virus interaction 472 | 472
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Programmed cell death 6-interacting protein PDCD6IP Tbio Non-IDG -1.59404 35.1 216
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G Tbio Non-IDG -2.78510 662.2 477
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Keratin, type II cytoskeletal 8 KRT8 Tbio Non-IDG -2.87670 710.7 1827
Aminopeptidase N ANPEP Tchem Enzyme -3.28127 1843.4 1222
DDB1- and CUL4-associated factor 1 DCAF1 Tbio Non-IDG -1.71452 57.7 62