Development Level

Tbio 15 | 11,445
Tclin 6 | 613
Tdark 4 | 6,588
Tchem 1 | 1,598

Collection

Ion Channel: IDG Consortium (T... 14 | 99

IMPC Phenotype

decreased circulating glucose ... 2 | 126
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal placenta vasculature 1 | 2
cyanosis 1 | 7
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
edema 1 | 59
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased startle reflex 1 | 112
prenatal lethality 1 | 28
preweaning lethality, complete... 1 | 979
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2

Disease

Carcinoma 19 | 11,493
adult high grade glioma 13 | 3,801
glioblastoma 13 | 5,792
medulloblastoma, large-cell 13 | 6,241
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 12 | 5,112
Astrocytoma, Pilocytic 11 | 3,081
ependymoma 10 | 4,679
ovarian cancer 10 | 8,520
psoriasis 10 | 6,694
Atrial Fibrillation 9 | 124
Brugada syndrome 9 | 29
primitive neuroectodermal tumor 9 | 3,035
Kidney cancer 8 | 2,613
oligodendroglioma 8 | 2,850
Long QT syndrome 7 | 39
Bipolar Disorder 6 | 666
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
Timothy syndrome 6 | 11
group 3 medulloblastoma 6 | 4,104
lung carcinoma 6 | 2,843
subependymal giant cell astrocytoma 6 | 2,287
Short QT syndrome 5 | 12
Syncope 5 | 22
Type 2 diabetes mellitus 5 | 272
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung adenocarcinoma 5 | 2,716
lung cancer 5 | 4,740
Angina Pectoris 4 | 32
Breast cancer 4 | 3,578
Brugada Syndrome (disorder) 4 | 15
Cardiac arrest 4 | 36
Epilepsy 4 | 792
Hypertensive disorder 4 | 56
Malignant hyperthermia 4 | 26
Prinzmetal angina 4 | 6
Prolonged QT interval 4 | 15
Skin cancer 4 | 469
Sudden Cardiac Death 4 | 29
Ventricular Fibrillation 4 | 17
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pituitary cancer 4 | 1,972
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 3 | 21
Atrioventricular block 3 | 35
Autosomal recessive predisposition 3 | 1,442
Cardiac Arrhythmia 3 | 103
Cardiomyopathy 3 | 116
Catecholaminergic polymorphic ventricular tachycardia 3 | 12
Endometrial cancer 3 | 311
Hypertension 3 | 396
Hypertensive disease 3 | 292
Hypokalemia 3 | 52
Hypokalemic periodic paralysis 3 | 11
Melanoma 3 | 711
Romano-Ward Syndrome 3 | 12
Shortened QT interval 3 | 5
Subarachnoid intracranial hemorrhage 3 | 3
Torsades de Pointes 3 | 8
active Crohn's disease 3 | 922
astrocytoma 3 | 1,146
invasive ductal carcinoma 3 | 2,951
malignant mesothelioma 3 | 3,232
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
Ataxia 2 | 15
Cardioversion of Atrial Fibrillation 2 | 9
Cerebrovascular accident 2 | 63
Congenital deafness 2 | 185
Deafness 2 | 198
Diabetic peripheral neuropathy 2 | 4
Electromyogram abnormal 2 | 49
Familial atrial fibrillation 2 | 23
Generalized anxiety disorder 2 | 29
Hearing Loss, Partial 2 | 185
Heart conduction disease 2 | 83
Hyperglycemia, Postprandial 2 | 8
Liver cancer 2 | 604
Long QT syndrome 1 2 | 20
Major Depressive Disorder 2 | 301
Mood Disorders 2 | 184
Night Blindness 2 | 101
Night blindness, congenital stationary 2 | 16
Postherpetic neuralgia 2 | 11
Refractive error 2 | 50
Sensorineural hearing loss 2 | 106
Severe mental retardation (I.Q. 20-34) 2 | 99
Thyrotoxicosis 2 | 38
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
hearing impairment 2 | 199
medulloblastoma 2 | 720
nasopharyngeal carcinoma 2 | 1,058
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
posterior fossa group A ependymoma 2 | 468

Tissue

Endocrine System 26 | 18,159
Nervous System 25 | 16,725
Digestive Tract 24 | 17,369
Blood and immune system 23 | 16,909
Male tissues 23 | 17,142
Female tissues 22 | 17,400
Skin and soft tissues 22 | 17,230
Respiratory system 21 | 16,393
Urinary Tract 20 | 16,678
Liver and Pancreas 19 | 16,750
Cardiovascular System 16 | 15,192

Target Family

Ion Channel 25 | 344
Non-IDG 1 | 12,091

Reactome Pathway

Phase 2 - plateau phase 26 | 26
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 Tbio Ion Channel -0.90841 6.64 294
Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 Tbio Ion Channel -1.56337 35.6 234
Voltage-dependent calcium channel gamma-4 subunit CACNG4 Tbio Ion Channel -0.64900 4.02 117
Voltage-dependent calcium channel gamma-3 subunit CACNG3 Tbio Ion Channel -0.41814 2.58 173
Voltage-dependent calcium channel gamma-5 subunit CACNG5 Tdark Ion Channel -0.05799 1.44 68
Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 Tbio Ion Channel -1.16723 13.5 158