Development Level

Tbio 25 | 11,445
Tchem 10 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

decreased body weight 3 | 161
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
male infertility 2 | 123
short tibia 2 | 97
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal rib morphology 1 | 10
abnormal skin morphology 1 | 50
cataract 1 | 92
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
female infertility 1 | 60
hypoactivity 1 | 132
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
vertebral fusion 1 | 23

Disease

Carcinoma 29 | 11,493
ovarian cancer 27 | 8,520
osteosarcoma 22 | 7,950
glioblastoma 18 | 5,792
lung cancer 18 | 4,740
Cancer 17 | 2,499
atypical teratoid / rhabdoid tumor 15 | 5,112
medulloblastoma, large-cell 15 | 6,241
psoriasis 15 | 6,694
astrocytic glioma 12 | 2,597
Multiple myeloma 11 | 1,332
ependymoma 11 | 4,679
Breast cancer 10 | 3,578
adult high grade glioma 10 | 3,801
malignant mesothelioma 10 | 3,232
subependymal giant cell astrocytoma 10 | 2,287
Cognitive delay 9 | 608
Downward slant of palpebral fissure 9 | 158
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Orbital separation excessive 9 | 244
Poor school performance 9 | 645
pancreatic cancer 9 | 2,398
Cryptorchidism 8 | 296
Epilepsy 8 | 792
Muscle hypotonia 8 | 571
Seizures 8 | 596
Short stature 8 | 531
Strabismus 8 | 270
interstitial cystitis 8 | 2,312
oligodendroglioma 8 | 2,850
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Hypoplastic mandible condyle 7 | 275
Kidney cancer 7 | 2,613
Lung Neoplasms 7 | 232
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Neck webbing 7 | 35
Noonan syndrome 7 | 34
Pectus excavatum 7 | 100
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Abnormality of vision 6 | 40
Acquired scoliosis 6 | 281
Anteverted nostril 6 | 191
Big calvaria 6 | 147
Biparietal narrowing 6 | 28
Chubby cheeks 6 | 50
Concave bridge of nose 6 | 195
Congenital Epicanthus 6 | 177
Curly hair (finding) 6 | 14
Curvature of spine 6 | 282
Decreased width of the skull 6 | 28
Delayed bone age 6 | 136
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Electroencephalogram abnormal 6 | 101
Feeding difficulties in infancy 6 | 175
Frontal bossing 6 | 157
Full cheeks 6 | 50
Hemangioma, Cavernous 6 | 20
High forehead 6 | 102
Hyperplasia of cheeks 6 | 50
Hypertrophy of cheeks 6 | 50
Ichthyoses 6 | 41
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Low posterior hairline 6 | 52
Low-set, posteriorly rotated ears 6 | 110
Melanoma 6 | 711
Premature Birth 6 | 77
Premature birth of newborn 6 | 67
Puffy cheeks 6 | 50
Pulmonary Stenosis 6 | 45
Short neck 6 | 140
Stomach Neoplasms 6 | 300
Tall forehead 6 | 102
Thickened helices 6 | 15
Waldenstrons macroglobulinemia 6 | 765
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
primary pancreatic ductal adenocarcinoma 6 | 1,109
primitive neuroectodermal tumor 6 | 3,035
Pick disease 5 | 1,894
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962

Tissue

Blood and immune system 39 | 16,909
Digestive Tract 39 | 17,369
Endocrine System 39 | 18,159
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Cardiovascular System 37 | 15,192
Respiratory system 37 | 16,393

Target Family

Enzyme 23 | 4,145
Kinase 8 | 634
Non-IDG 8 | 12,091

Reactome Pathway

Negative regulation of MAPK pa... 39 | 39
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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