Development Level

Tbio 51 | 11,445
Tchem 14 | 1,598
Tdark 5 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased bone mineral content 3 | 108
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased fasted circulating g... 2 | 65
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased cardiac output 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased glycosylated hemoglo... 1 | 1
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
long tibia 1 | 25
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 50 | 11,493
osteosarcoma 48 | 7,950
ovarian cancer 39 | 8,520
medulloblastoma, large-cell 34 | 6,241
glioblastoma 32 | 5,792
psoriasis 29 | 6,694
atypical teratoid / rhabdoid tumor 26 | 5,112
adult high grade glioma 25 | 3,801
lung cancer 25 | 4,740
Cancer 22 | 2,499
group 3 medulloblastoma 20 | 4,104
ependymoma 18 | 4,679
primitive neuroectodermal tumor 18 | 3,035
astrocytic glioma 15 | 2,597
malignant mesothelioma 15 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Kidney cancer 13 | 2,613
Multiple myeloma 13 | 1,332
Pick disease 13 | 1,894
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 12 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Breast cancer 11 | 3,578
Obesity 11 | 678
diabetes mellitus 11 | 1,728
invasive ductal carcinoma 11 | 2,951
Schizophrenia 10 | 1,160
subependymal giant cell astrocytoma 10 | 2,287
group 4 medulloblastoma 9 | 1,855
pituitary cancer 9 | 1,972
Waldenstrons macroglobulinemia 8 | 765
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
non-small cell lung cancer 8 | 2,890
tuberculosis 8 | 2,010
Parkinson's disease 7 | 392
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
Breast Neoplasms 6 | 445
Cardiomegaly 6 | 116
Cardiomyopathies 6 | 110
Mammary Neoplasms 6 | 425
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
acute quadriplegic myopathy 6 | 1,158
interstitial cystitis 6 | 2,312
lung adenocarcinoma 6 | 2,716
Alzheimer's disease 5 | 658
Bipolar Disorder 5 | 666
Depressive disorder 5 | 409
Endometriosis 5 | 540
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Muscle hypotonia 5 | 571
Seizures 5 | 596
breast carcinoma 5 | 1,638
ulcerative colitis 5 | 1,819
Diabetes Mellitus, Experimental 4 | 108
Fatty Liver 4 | 70
Fatty liver disease 4 | 103
Hyperglycemia 4 | 137
Liver neoplasms 4 | 130
Myocardial Infarction 4 | 151
acute myeloid leukemia 4 | 783
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
atypical teratoid/rhabdoid tumor 4 | 357
gastric carcinoma 4 | 807
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
Atherosclerosis 3 | 291
Autistic Disorder 3 | 364
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Chronic progressive external ophthalmoplegia 3 | 26
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Disease Progression 3 | 136
Down syndrome 3 | 499
Heart disease 3 | 306
Huntington's disease 3 | 76
Hypoglycemia 3 | 152
Liver carcinoma 3 | 240
Mental Depression 3 | 333
Mesothelioma, Malignant 3 | 105
Methylmalonic acidemia 3 | 37
Myocardial Ischemia 3 | 169
Myopathy 3 | 185
Neuropathy 3 | 261
Peripheral T-cell lymphoma 3 | 25
Primary cutaneous T-cell lymphoma 3 | 29
Urinary Bladder Neoplasms 3 | 114
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group A ependymoma 3 | 468
posterior fossa group B ependymoma 3 | 416

Tissue

Cardiovascular System 74 | 15,192
Digestive Tract 74 | 17,369
Endocrine System 74 | 18,159
Male tissues 74 | 17,142
Skin and soft tissues 74 | 17,230
Female tissues 73 | 17,400
Urinary Tract 73 | 16,678
Blood and immune system 72 | 16,909
Liver and Pancreas 72 | 16,750
Nervous System 72 | 16,725
Respiratory system 72 | 16,393

Target Family

Non-IDG 29 | 12,091
Enzyme 18 | 4,145
Epigenetic 8 | 242
Transcription Factor 8 | 1,400
Kinase 7 | 634
Nuclear Receptor 4 | 48

Reactome Pathway

Mitochondrial biogenesis 74 | 74
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Steroid hormone receptor ERR1 ESRRA Tchem Nuclear Receptor -2.13451 156.7 356
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 PPRC1 Tbio Non-IDG -2.48090 295.1 100
DNA-directed RNA polymerase, mitochondrial POLRMT Tbio Enzyme -1.75977 55.2 71
Nuclear receptor subfamily 1 group D member 1 NR1D1 Tchem Nuclear Receptor -1.95952 81.6 389
MICOS complex subunit MIC27 APOOL Tbio Non-IDG -0.75265 5.04 95
Nuclear receptor coactivator 6 NCOA6 Tbio Non-IDG -1.83369 72.1 54
Transcription factor A, mitochondrial TFAM Tbio Transcription Factor -2.72618 499.4 378
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 SMARCD3 Tbio Non-IDG -1.30404 22.1 170
Mitogen-activated protein kinase 12 MAPK12 Tchem Kinase -1.95173 88.4 378