Development Level

Tbio 1,355 | 11,445
Tdark 308 | 6,588
Tchem 222 | 1,598
Tclin 77 | 613

Collection

Kinase: IDG Consortium (Target... 9 | 125
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 5 | 99
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 142 | 979
preweaning lethality, incomple... 66 | 499
abnormal behavior 39 | 298
embryonic lethality prior to t... 35 | 278
embryonic lethality prior to o... 31 | 239
abnormal embryo size 30 | 220
decreased total body fat amoun... 27 | 207
enlarged heart 26 | 210
decreased lean body mass 25 | 135
increased lean body mass 23 | 172
abnormal heart morphology 20 | 162
increased startle reflex 20 | 112
decreased circulating glucose ... 19 | 126
hypoactivity 19 | 132
abnormal bone structure 18 | 187
decreased body weight 18 | 161
decreased circulating choleste... 18 | 93
increased bone mineral density 18 | 72
increased or absent threshold ... 18 | 101
increased total body fat amoun... 18 | 134
decreased vertical activity 17 | 208
decreased bone mineral density 16 | 126
abnormal seminal vesicle morph... 15 | 114
cataract 15 | 92
decreased bone mineral content 15 | 151
decreased circulating HDL chol... 15 | 68
hyperactivity 15 | 148
increased circulating alkaline... 14 | 122
abnormal coat-hair pigmentatio... 13 | 64
decreased prepulse inhibition 13 | 82
embryonic growth retardation 13 | 106
increased mean corpuscular vol... 13 | 92
prenatal lethality prior to he... 13 | 87
short tibia 13 | 97
decreased circulating serum al... 12 | 82
decreased fasted circulating g... 12 | 65
decreased leukocyte cell numbe... 12 | 73
improved glucose tolerance 12 | 79
increased bone mineral content 12 | 108
increased circulating choleste... 12 | 66
increased mean corpuscular hem... 12 | 96
abnormal lens morphology 11 | 81
decreased grip strength 11 | 116
decreased circulating total pr... 10 | 49
decreased mean corpuscular vol... 10 | 79
abnormal eye morphology 9 | 68
decreased circulating triglyce... 9 | 79
decreased lymphocyte cell numb... 9 | 83
male infertility 9 | 123
abnormal gait 8 | 69
abnormal retina morphology 8 | 71
abnormal snout morphology 8 | 23
decreased circulating insulin ... 8 | 76
edema 8 | 59
increased circulating HDL chol... 8 | 80
increased fasted circulating g... 8 | 76
increased heart weight 8 | 62
small superior vagus ganglion 8 | 74
thrombocytopenia 8 | 56
abnormal kidney morphology 7 | 65
abnormal neural tube closure 7 | 46
abnormal sleep behavior 7 | 70
abnormal testis morphology 7 | 43
cardiovascular system phenotyp... 7 | 36
decreased blood urea nitrogen ... 7 | 51
decreased body length 7 | 101
decreased caudal vertebrae num... 7 | 53
decreased circulating LDL chol... 7 | 38
decreased circulating alkaline... 7 | 46
decreased erythrocyte cell num... 7 | 62
persistence of hyaloid vascula... 7 | 33
prolonged QT interval 7 | 38
abnormal behavioral response t... 6 | 66
abnormal bone mineralization 6 | 38
abnormal epididymis morphology 6 | 42
abnormal retinal blood vessel ... 6 | 26
abnormal skin morphology 6 | 50
abnormal tooth morphology 6 | 24
corneal opacity 6 | 32
decreased hemoglobin content 6 | 68
decreased mean corpuscular hem... 6 | 50
increased blood urea nitrogen ... 6 | 48
increased body weight 6 | 25
increased circulating sodium l... 6 | 71
increased hematocrit 6 | 46
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
increased monocyte cell number 6 | 63
increased prepulse inhibition 6 | 32
microphthalmia 6 | 26
pallor 6 | 34
small testis 6 | 58
vertebral fusion 6 | 23
abnormal retinal vasculature m... 5 | 27
anophthalmia 5 | 33
decreased circulating creatini... 5 | 39
impaired glucose tolerance 5 | 75
increased circulating calcium ... 5 | 34
increased mean platelet volume 5 | 45
pale yolk sac 5 | 25

Disease

pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Liver and Pancreas 1,941 | 16,750
Urinary Tract 1,936 | 16,678
Endocrine System 1,934 | 18,159
Digestive Tract 1,932 | 17,369
Female tissues 1,924 | 17,400
Skin and soft tissues 1,919 | 17,230
Male tissues 1,911 | 17,142
Blood and immune system 1,904 | 16,909
Nervous System 1,897 | 16,725
Respiratory system 1,887 | 16,393
Cardiovascular System 1,836 | 15,192

Target Family

Non-IDG 1,043 | 12,091
Enzyme 619 | 4,145
Transcription Factor 87 | 1,400
Transporter 81 | 473
Kinase 65 | 634
Epigenetic 25 | 242
Ion Channel 17 | 344
GPCR 14 | 408
Nuclear Receptor 7 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier family 25 member 47 SLC25A47 Tbio Transporter 0.03 0.48 83
Numb-like protein NUMBL Tbio Non-IDG -2.50313 317.9 171
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
Sarcosine dehydrogenase, mitochondrial SARDH Tbio Enzyme -1.78290 56.5 35
Transmembrane protein 64 TMEM64 Tdark Non-IDG -0.22185 1.46 9
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
HEAT repeat-containing protein 5A HEATR5A Tdark Non-IDG 0.00000 5