Development Level

Tbio 1,392 | 10,625
Tdark 541 | 7,003
Tchem 248 | 1,890
Tclin 73 | 602

Collection

Kinase: IDG Consortium (Targets) 12 | 125
Ion Channel: IDG Consortium (Targets) 7 | 102
Kinase: IDG Consortium (Complete/Control) 4 | 37
GPCR: IDG Consortium (Complete/Control) 2 | 26
GPCR: IDG Consortium (Targets) 2 | 127

IMPC Phenotype

preweaning lethality, complete... 105 | 633
embryonic lethality prior to t... 37 | 187
abnormal behavior 35 | 226
preweaning lethality, incomple... 35 | 260
decreased lean body mass 32 | 195
embryonic lethality prior to o... 26 | 148
increased or absent threshold ... 25 | 128
decreased body weight 24 | 174
decreased total body fat amoun... 21 | 186
enlarged heart 20 | 111
increased circulating alkaline... 19 | 119
increased lean body mass 19 | 107
increased mean corpuscular hem... 18 | 93
abnormal embryo size 17 | 112
decreased bone mineral content 17 | 157
decreased circulating glucose ... 17 | 121
decreased circulating insulin ... 17 | 75
decreased grip strength 17 | 123
hyperactivity 17 | 108
decreased lumbar vertebrae num... 16 | 62
increased sacral vertebrae num... 16 | 62
decreased body length 14 | 108
hypoactivity 14 | 89
increased grip strength 14 | 83
decreased circulating choleste... 13 | 85
increased mean corpuscular vol... 13 | 91
short tibia 13 | 82
abnormal bone structure 12 | 131
abnormal retina morphology 12 | 100
decreased bone mineral density 12 | 126
decreased circulating HDL chol... 12 | 77
increased fasted circulating g... 12 | 68
prenatal lethality prior to he... 12 | 64
abnormal lens morphology 11 | 73
decreased circulating serum al... 11 | 79
increased bone mineral content 11 | 92
abnormal behavioral response t... 10 | 52
abnormal cranium morphology 10 | 32
abnormal sleep behavior 10 | 63
decreased caudal vertebrae num... 10 | 49
decreased prepulse inhibition 10 | 52
abnormal coat-hair pigmentatio... 9 | 54
decreased leukocyte cell numbe... 9 | 54
decreased threshold for audito... 9 | 32
increased blood urea nitrogen ... 9 | 44
increased hemoglobin content 9 | 45
increased startle reflex 9 | 38
male infertility 9 | 62
thrombocytopenia 9 | 46
decreased circulating triglyce... 8 | 83
decreased startle reflex 8 | 48
enlarged spleen 8 | 26
improved glucose tolerance 8 | 56
increased circulating chloride... 8 | 43
increased circulating sodium l... 8 | 71
increased exploration in new e... 8 | 56
increased leukocyte cell numbe... 8 | 37
increased mean corpuscular hem... 8 | 25
increased total body fat amoun... 8 | 57
cardiovascular system phenotyp... 7 | 35
decreased circulating total pr... 7 | 41
decreased mean corpuscular vol... 7 | 50
decreased rib number 7 | 59
enlarged lymph nodes 7 | 27
increased bone mineral density 7 | 52
increased rib number 7 | 41
abnormal bone mineralization 6 | 55
abnormal spleen morphology 6 | 36
decreased B cell number 6 | 30
decreased effector memory CD8-... 6 | 24
increased circulating HDL chol... 6 | 63
increased heart weight 6 | 37
limb grasping 6 | 35
abnormal coat- hair morphology 5 | 18
abnormal eye morphology 5 | 38
abnormal head morphology 5 | 10
abnormal heart morphology 5 | 51
abnormal kidney morphology 5 | 30
abnormal retinal pigmentation 5 | 61
abnormal snout morphology 5 | 18
decreased CD4-positive, CD25-p... 5 | 24
decreased CD8-positive, alpha-... 5 | 26
decreased circulating alanine ... 5 | 53
decreased circulating alkaline... 5 | 41
decreased circulating calcium ... 5 | 33
decreased circulating free fat... 5 | 39
decreased heart weight 5 | 44
decreased mean corpuscular hem... 5 | 34
decreased vertical activity 5 | 22
embryonic growth retardation 5 | 28
impaired glucose tolerance 5 | 52
increased circulating calcium ... 5 | 32
increased circulating choleste... 5 | 53
increased circulating creatini... 5 | 29
increased circulating glucose ... 5 | 16
increased prepulse inhibition 5 | 21
polydactyly 5 | 22
tremors 5 | 34
vertebral fusion 5 | 23
decreased fasted circulating g... 4 | 49

Disease

group 3 medulloblastoma 2,254 | 2,254
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,233 | 18,560
Female tissues 2,230 | 18,646
Digestive Tract 2,227 | 18,472
Liver and Pancreas 2,226 | 18,135
Urinary Tract 2,226 | 18,443
Endocrine System 2,224 | 18,511
Male tissues 2,222 | 17,968
Blood and immune system 2,221 | 17,994
Cardiovascular System 2,221 | 17,957
Skin and soft tissues 2,213 | 18,114
Respiratory system 2,203 | 17,483

Target Family

Non-IDG 1,350 | 11,969
Enzyme 488 | 4,146
Transcription Factor 164 | 1,400
Kinase 90 | 634
Epigenetic 46 | 242
Transporter 46 | 473
Ion Channel 29 | 341
GPCR 26 | 408
Nuclear Receptor 7 | 48
TF/Epigenetic 6 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein 7 RBM7 Tbio Non-IDG -0.67056 6.57 67
Ribosomal biogenesis protein LAS1L LAS1L Tdark Non-IDG -0.45120 2.84 94
Kelch repeat and BTB domain-containing protein 4 KBTBD4 Tdark Non-IDG 0.60 0.20 49
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.42636 263.7 235
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 117
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.53667 324.2 196
IgLON family member 5 IGLON5 Tdark Non-IDG -1.24569 14.2 30
Coiled-coil domain-containing protein 141 CCDC141 Tdark Non-IDG -0.61681 3.82 82
Alpha-1-antitrypsin SERPINA1 Tbio Non-IDG -3.73976 5495.0 809