Development Level

Tbio 10,194 | 11,651
Tdark 3,993 | 6,593
Tchem 1,251 | 1,388
Tclin 521 | 612

Collection

RFA-RM-18-021 241 | 328
Kinase: IDG Consortium (Target... 112 | 125
GPCR: IDG Consortium (Targets) 69 | 126
Ion Channel: IDG Consortium (T... 69 | 99
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 464 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 189 | 207
enlarged heart 189 | 210
decreased vertical activity 172 | 208
abnormal bone structure 169 | 187
increased lean body mass 158 | 172
decreased body weight 150 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 135 | 151
hyperactivity 134 | 148
decreased lean body mass 124 | 135
increased total body fat amoun... 120 | 134
decreased circulating glucose ... 118 | 126
hypoactivity 116 | 132
decreased bone mineral density 114 | 126
increased circulating alkaline... 111 | 122
embryonic growth retardation 102 | 106
male infertility 102 | 123
decreased grip strength 101 | 116
increased startle reflex 101 | 112
abnormal seminal vesicle morph... 100 | 114
increased bone mineral content 96 | 108
decreased body length 94 | 101
increased or absent threshold ... 92 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
cataract 88 | 92
increased mean corpuscular hem... 87 | 96
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 74 | 79
decreased circulating serum al... 73 | 82
decreased mean corpuscular vol... 72 | 79
decreased startle reflex 70 | 75
increased fasted circulating g... 70 | 76
decreased leukocyte cell numbe... 69 | 73
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
improved glucose tolerance 68 | 79
abnormal eye morphology 65 | 68
abnormal retina morphology 65 | 71
decreased circulating HDL chol... 65 | 68
impaired glucose tolerance 64 | 75
increased circulating sodium l... 64 | 71
decreased circulating insulin ... 63 | 76
small superior vagus ganglion 63 | 74
abnormal sleep behavior 62 | 70
abnormal coat-hair pigmentatio... 61 | 64
abnormal gait 61 | 69
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 60 | 68
decreased erythrocyte cell num... 59 | 62
increased circulating choleste... 58 | 66
increased heart weight 58 | 62
increased monocyte cell number 58 | 63
abnormal behavioral response t... 56 | 66
abnormal kidney morphology 56 | 65
edema 55 | 59
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 52 | 56
abnormal spleen morphology 51 | 55
small testis 51 | 58
abnormal skin morphology 48 | 50
female infertility 47 | 60
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
hydrometra 45 | 53
increased blood urea nitrogen ... 44 | 48
decreased circulating alanine ... 43 | 47
decreased hematocrit 43 | 46
decreased circulating alkaline... 42 | 46
increased neutrophil cell numb... 42 | 46
increased hematocrit 41 | 46
increased leukocyte cell numbe... 41 | 47
enlarged spleen 40 | 41
increased circulating chloride... 39 | 41
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
increased mean platelet volume 38 | 45
abnormal epididymis morphology 37 | 42
decreased neutrophil cell numb... 37 | 42
increased hemoglobin content 37 | 45
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
tremors 36 | 39
abnormal cranium morphology 35 | 36
decreased circulating creatini... 35 | 39
increased erythrocyte cell num... 35 | 39
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,749 | 11,493
ovarian cancer 8,100 | 8,520
osteosarcoma 7,413 | 7,950
medulloblastoma, large-cell 5,774 | 6,241
psoriasis 5,664 | 6,694
glioblastoma 5,467 | 5,792
atypical teratoid / rhabdoid tumor 4,793 | 5,112
lung cancer 4,456 | 4,740
ependymoma 4,376 | 4,679
group 3 medulloblastoma 3,846 | 4,104
adult high grade glioma 3,494 | 3,801
Breast cancer 3,365 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,166 | 3,291
malignant mesothelioma 3,085 | 3,232
invasive ductal carcinoma 2,878 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,869 | 2,989
primitive neuroectodermal tumor 2,847 | 3,035
Astrocytoma, Pilocytic 2,843 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,837 | 2,955
non-small cell lung cancer 2,752 | 2,890
lung carcinoma 2,667 | 2,843
oligodendroglioma 2,655 | 2,850
lung adenocarcinoma 2,546 | 2,716
astrocytic glioma 2,423 | 2,597
Kidney cancer 2,313 | 2,613
pancreatic cancer 2,259 | 2,398
Cancer 2,194 | 2,499
interstitial cystitis 2,176 | 2,312
subependymal giant cell astrocytoma 2,164 | 2,287
tuberculosis 1,906 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,873 | 1,962
pituitary cancer 1,842 | 1,972
Pick disease 1,815 | 1,894
group 4 medulloblastoma 1,754 | 1,855
ulcerative colitis 1,713 | 1,819
ductal carcinoma in situ 1,691 | 1,745
cystic fibrosis 1,589 | 1,696
breast carcinoma 1,576 | 1,638
colon cancer 1,392 | 1,478
adrenocortical carcinoma 1,391 | 1,428
diabetes mellitus 1,332 | 1,728
Multiple myeloma 1,305 | 1,332
Autosomal recessive predisposition 1,285 | 1,442
juvenile dermatomyositis 1,162 | 1,187
acute quadriplegic myopathy 1,133 | 1,158
astrocytoma 1,109 | 1,146
primary pancreatic ductal adenocarcinoma 1,080 | 1,109
Rheumatoid arthritis 1,073 | 1,191
pediatric high grade glioma 1,017 | 1,064
spina bifida 1,007 | 1,074
cutaneous lupus erythematosus 994 | 1,057
Schizophrenia 991 | 1,160
nasopharyngeal carcinoma 970 | 1,058
Intellectual disability 942 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 864 | 922
Atopic dermatitis 841 | 952
non primary Sjogren syndrome sicca 812 | 891
gastric carcinoma 774 | 807
acute myeloid leukemia 772 | 783
Waldenstrons macroglobulinemia 757 | 765
Liver Cirrhosis, Experimental 724 | 769
Epilepsy 721 | 792
primary Sjogren syndrome 708 | 735
active ulcerative colitis 700 | 764
esophageal adenocarcinoma 682 | 737
medulloblastoma 675 | 720
progressive supranuclear palsy 650 | 676
aldosterone-producing adenoma 641 | 665
Alzheimer's disease 599 | 658
Dull intelligence 598 | 645
Low intelligence 598 | 645
Mental Retardation 598 | 645
Mental deficiency 598 | 645
Poor school performance 598 | 645
Obesity 593 | 678
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Duchenne muscular dystrophy 578 | 601
Bipolar Disorder 568 | 666
Melanoma 551 | 711
Seizures 548 | 596
pancreatic carcinoma 547 | 562
Muscle hypotonia 541 | 571
fibroadenoma 538 | 559
hepatocellular carcinoma 530 | 547
Liver cancer 518 | 604
Endometriosis 497 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Short stature 489 | 531
chronic rhinosinusitis 479 | 512
Down syndrome 470 | 499
Prostatic Neoplasms 457 | 495
Multiple Sclerosis 453 | 540
gastric cancer 449 | 459
mucosa-associated lymphoid tissue lymphoma 442 | 484
posterior fossa group A ependymoma 438 | 468
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 432 | 451

Tissue

Endocrine System 15,959 | 18,159
Female tissues 15,861 | 17,400
Digestive Tract 15,826 | 17,369
Skin and soft tissues 15,794 | 17,230
Male tissues 15,788 | 17,142
Liver and Pancreas 15,676 | 16,750
Blood and immune system 15,672 | 16,909
Urinary Tract 15,627 | 16,678
Nervous System 15,595 | 16,725
Respiratory system 15,541 | 16,393
Cardiovascular System 14,751 | 15,192

Target Family

Non-IDG 9,300 | 12,091
Enzyme 3,668 | 4,145
Transcription Factor 1,166 | 1,400
Kinase 589 | 634
Transporter 386 | 473
GPCR 268 | 408
Ion Channel 249 | 344
Epigenetic 230 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 35 | 38
oGPCR 25 | 421

HPA RNA Tissue

thyroid gland 15,959 | 15,959
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
HEAT repeat-containing protein 5A HEATR5A Tdark Non-IDG 0.00000 5
Protein HIDE1 C19orf38 Tdark Non-IDG 0.00000 57
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2