Development Level

Tbio 88 | 11,651
Tchem 41 | 1,388
Tclin 2 | 612
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to o... 8 | 239
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 5 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
abnormal heart morphology 3 | 162
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
increased circulating HDL chol... 3 | 80
increased mean platelet volume 3 | 45
abnormal blood vessel morpholo... 2 | 5
abnormal lens morphology 2 | 81
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal coat- hair morphology 1 | 19
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal pharyngeal arch morph... 1 | 8
abnormal response to new envir... 1 | 10
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
enlarged thymus 1 | 5
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body temperature 1 | 9
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased glycosylated hemoglo... 1 | 1
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
male infertility 1 | 123
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39

Disease

Carcinoma 92 | 11,493
osteosarcoma 79 | 7,950
ovarian cancer 77 | 8,520
lung cancer 61 | 4,740
medulloblastoma, large-cell 59 | 6,241
glioblastoma 53 | 5,792
Cancer 52 | 2,499
atypical teratoid / rhabdoid tumor 46 | 5,112
group 3 medulloblastoma 46 | 4,104
psoriasis 44 | 6,694
malignant mesothelioma 39 | 3,232
Breast cancer 38 | 3,578
primitive neuroectodermal tumor 38 | 3,035
ependymoma 35 | 4,679
adult high grade glioma 33 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
oligodendroglioma 27 | 2,850
Kidney cancer 26 | 2,613
non-small cell lung cancer 26 | 2,890
astrocytic glioma 21 | 2,597
invasive ductal carcinoma 20 | 2,951
colon cancer 19 | 1,478
Astrocytoma, Pilocytic 18 | 3,081
Intellectual disability 17 | 1,016
subependymal giant cell astrocytoma 17 | 2,287
Breast Neoplasms 16 | 445
diabetes mellitus 16 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
ductal carcinoma in situ 15 | 1,745
nasopharyngeal carcinoma 15 | 1,058
Autosomal recessive predisposition 14 | 1,442
Mammary Neoplasms 14 | 425
Schizophrenia 14 | 1,160
adrenocortical carcinoma 14 | 1,428
group 4 medulloblastoma 14 | 1,855
Pick disease 13 | 1,894
breast carcinoma 13 | 1,638
lung adenocarcinoma 13 | 2,716
Squamous cell carcinoma 12 | 129
Waldenstrons macroglobulinemia 12 | 765
Ataxia telangiectasia 11 | 34
Carcinoma, Squamous Cell 11 | 110
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Short stature 11 | 531
Small head 11 | 374
acute quadriplegic myopathy 11 | 1,158
juvenile dermatomyositis 11 | 1,187
pediatric high grade glioma 11 | 1,064
pituitary cancer 11 | 1,972
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Nijmegen breakage syndrome 10 | 24
Poor school performance 10 | 645
Prostatic Neoplasms 10 | 495
Rheumatoid arthritis 10 | 1,191
lung carcinoma 10 | 2,843
medulloblastoma 10 | 720
Bloom syndrome 9 | 29
Endometriosis 9 | 540
Melanoma 9 | 711
Multiple myeloma 9 | 1,332
Stomach Neoplasms 9 | 300
non primary Sjogren syndrome sicca 9 | 891
pancreatic cancer 9 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Alzheimer's disease 8 | 658
Amyotrophic lateral sclerosis 8 | 451
Anemia 8 | 365
Endometrial cancer 8 | 311
Hereditary Breast and Ovarian Cancer Syndrome 8 | 14
Lung Neoplasms 8 | 232
Renal Cell Carcinoma 8 | 214
acute myeloid leukemia 8 | 783
astrocytoma 8 | 1,146
dermatomyositis 8 | 966
interstitial cystitis 8 | 2,312
tuberculosis 8 | 2,010
Asthma 7 | 385
Colorectal Neoplasms 7 | 243
Epilepsy 7 | 792
Fanconi anemia 7 | 56
Pancreatic Neoplasm 7 | 85
Seckel syndrome 7 | 34
Seizures 7 | 596
Skin Neoplasms 7 | 69
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
tuberculosis and treatment for 6 months 7 | 409
ulcerative colitis 7 | 1,819
Cleft Palate 6 | 271
Cognitive delay 6 | 608
Glaucoma 6 | 239
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Uranostaphyloschisis 6 | 167
cystic fibrosis 6 | 1,696

Tissue

Endocrine System 133 | 18,159
Digestive Tract 131 | 17,369
Female tissues 131 | 17,400
Skin and soft tissues 131 | 17,230
Male tissues 130 | 17,142
Nervous System 130 | 16,725
Blood and immune system 129 | 16,909
Cardiovascular System 129 | 15,192
Liver and Pancreas 129 | 16,750
Urinary Tract 129 | 16,678
Respiratory system 128 | 16,393

Target Family

Non-IDG 62 | 12,091
Kinase 28 | 634
Epigenetic 19 | 242
Enzyme 15 | 4,145
Transcription Factor 8 | 1,400
TF/Epigenetic 1 | 38

GO Process

regulation of signal transduct... 133 | 133
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein PML PML Tbio Non-IDG -2.63785 373.8 470
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.41690 2313.9 1252
5'-AMP-activated protein kinase subunit beta-2 PRKAB2 Tbio Enzyme -0.79676 5.52 170
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.06074 11.3 79
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
MAP kinase-activated protein kinase 5 MAPKAPK5 Tchem Kinase -1.87360 78.8 436
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101