Development Level

Tbio 47 | 11,445
Tchem 4 | 1,598
Tdark 2 | 6,588
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

abnormal embryo size 3 | 220
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased blood urea nitrogen ... 2 | 48
increased mean corpuscular hem... 2 | 96
increased or absent threshold ... 2 | 101
pallor 2 | 34
thin ventricular wall 2 | 24
thrombocytopenia 2 | 56
abnormal cranium morphology 1 | 36
abnormal eating behavior 1 | 1
abnormal eye morphology 1 | 68
abnormal forced expiratory flo... 1 | 1
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal urinary bladder morph... 1 | 11
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
aorta dilation 1 | 3
aorta stenosis 1 | 2
cataract 1 | 92
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
decreased tidal volume 1 | 1
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged kidney 1 | 14
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
premature death 1 | 5
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 38 | 11,493
glioblastoma 28 | 5,792
medulloblastoma, large-cell 27 | 6,241
atypical teratoid / rhabdoid tumor 26 | 5,112
ependymoma 26 | 4,679
osteosarcoma 26 | 7,950
ovarian cancer 26 | 8,520
psoriasis 26 | 6,694
group 3 medulloblastoma 23 | 4,104
Astrocytoma, Pilocytic 20 | 3,081
Cancer 20 | 2,499
oligodendroglioma 20 | 2,850
lung cancer 16 | 4,740
primitive neuroectodermal tumor 15 | 3,035
Breast cancer 14 | 3,578
astrocytic glioma 14 | 2,597
malignant mesothelioma 13 | 3,232
pituitary cancer 13 | 1,972
Kidney cancer 12 | 2,613
Schizophrenia 12 | 1,160
Seizures 12 | 596
adult high grade glioma 12 | 3,801
subependymal giant cell astrocytoma 12 | 2,287
Epilepsy 11 | 792
non-small cell lung cancer 11 | 2,890
Intellectual disability 10 | 1,016
cystic fibrosis 10 | 1,696
lung carcinoma 10 | 2,843
pediatric high grade glioma 10 | 1,064
Bipolar Disorder 9 | 666
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
pancreatic cancer 9 | 2,398
group 4 medulloblastoma 8 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
Muscle hypotonia 7 | 571
Strabismus 7 | 270
acute quadriplegic myopathy 7 | 1,158
astrocytoma 7 | 1,146
Breast Neoplasms 6 | 445
Cryptorchidism 6 | 296
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Rheumatoid arthritis 6 | 1,191
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
juvenile dermatomyositis 6 | 1,187
primary pancreatic ductal adenocarcinoma 6 | 1,109
Autistic Disorder 5 | 364
Cognitive delay 5 | 608
Constipation 5 | 181
Global developmental delay 5 | 608
Mammary Neoplasms 5 | 425
Mental and motor retardation 5 | 608
Microcephaly 5 | 166
Short stature 5 | 531
Stomach Neoplasms 5 | 300
adrenocortical carcinoma 5 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Agenesis of corpus callosum 4 | 83
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Congenital hypoplasia of penis 4 | 176
Depressive disorder 4 | 409
Down syndrome 4 | 499
Downward slant of palpebral fissure 4 | 158
Dyschezia 4 | 135
Electroencephalogram abnormal 4 | 101
Endometriosis 4 | 540
Holoprosencephaly 4 | 56
Liver Cirrhosis, Experimental 4 | 769
Liver cancer 4 | 604
Low Vision 4 | 174
Lung Neoplasms 4 | 232
Neoplasm Invasiveness 4 | 161
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Posteriorly rotated ear 4 | 61
Small cell carcinoma of lung 4 | 45
Small head 4 | 374
Vascular disease 4 | 319
Visual Impairment 4 | 174
active Crohn's disease 4 | 922
active ulcerative colitis 4 | 764
aldosterone-producing adenoma 4 | 665
dermatomyositis 4 | 966
non primary Sjogren syndrome sicca 4 | 891
Duchenne muscular dystrophy 3 | 601
Prostatic Neoplasms 3 | 495
esophageal adenocarcinoma 3 | 737

Tissue

Endocrine System 51 | 18,159
Digestive Tract 50 | 17,369
Nervous System 48 | 16,725
Skin and soft tissues 48 | 17,230
Blood and immune system 46 | 16,909
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Male tissues 46 | 17,142
Urinary Tract 43 | 16,678
Respiratory system 42 | 16,393
Cardiovascular System 37 | 15,192

Target Family

Transcription Factor 27 | 1,400
Non-IDG 17 | 12,091
Enzyme 6 | 4,145
GPCR 1 | 408
Kinase 1 | 634
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Process

negative regulation of neuron ... 54 | 54
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
eIF-2-alpha kinase GCN2 EIF2AK4 Tchem Kinase -2.43702 276.5 301
Protein dispatched homolog 3 DISP3 Tbio Non-IDG -0.85544 7.52 127
Homeobox protein SIX3 SIX3 Tbio Transcription Factor -2.84681 686.8 212
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175
Iroquois-class homeodomain protein IRX-3 IRX3 Tbio Transcription Factor -1.65610 44.8 282
Contactin-2 CNTN2 Tbio Non-IDG -2.59791 404.0 198
Homeobox protein Nkx-2.2 NKX2-2 Tbio Transcription Factor -2.06202 108.0 379
Prosaposin receptor GPR37L1 GPR37L1 Tbio GPCR -0.82502 6.15 201
Paired mesoderm homeobox protein 2B PHOX2B Tbio Transcription Factor -2.49193 315.4 127
Pre-B-cell leukemia transcription factor 1 PBX1 Tbio Transcription Factor -2.30640 200.0 232