Development Level

Tbio 121 | 11,445
Tclin 56 | 613
Tchem 42 | 1,598
Tdark 13 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 29 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 11 | 278
preweaning lethality, incomple... 8 | 499
abnormal embryo size 7 | 220
decreased vertical activity 7 | 208
increased heart weight 7 | 62
increased startle reflex 6 | 112
pallor 6 | 34
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
abnormal lens morphology 5 | 81
cataract 5 | 92
embryonic growth retardation 4 | 106
abnormal heart morphology 3 | 162
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
enlarged heart 3 | 210
enlarged spleen 3 | 41
hyperactivity 3 | 148
increased circulating alkaline... 3 | 122
increased circulating phosphat... 3 | 26
prenatal lethality prior to he... 3 | 87
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating chloride... 2 | 30
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
edema 2 | 59
hypoactivity 2 | 132
increased circulating bilirubi... 2 | 16
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased mean platelet volume 2 | 45
prenatal lethality 2 | 28
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal chorioallantoic fusio... 1 | 8
abnormal duodenum morphology 1 | 4
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta morphology 1 | 5
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
enlarged heart atrium 1 | 4
enlarged thymus 1 | 5
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
pale liver 1 | 6
short tibia 1 | 97
small adrenal glands 1 | 16
small kidney 1 | 16
small spleen 1 | 19

Disease

ovarian cancer 129 | 8,520
Carcinoma 110 | 11,493
osteosarcoma 96 | 7,950
lung cancer 75 | 4,740
medulloblastoma, large-cell 70 | 6,241
psoriasis 68 | 6,694
glioblastoma 64 | 5,792
atypical teratoid / rhabdoid tumor 58 | 5,112
Multiple myeloma 56 | 1,332
ependymoma 54 | 4,679
Diabetes mellitus type 2 51 | 69
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
Epilepsy 48 | 792
astrocytic glioma 45 | 2,597
Cancer 44 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
Seizures 43 | 596
group 3 medulloblastoma 42 | 4,104
Leigh disease 41 | 100
Autosomal recessive predisposition 40 | 1,442
Muscle hypotonia 40 | 571
Breast cancer 38 | 3,578
Cerebellar Ataxia 38 | 304
Cognitive delay 37 | 608
Global developmental delay 37 | 608
Mental and motor retardation 37 | 608
diabetes mellitus 37 | 1,728
Blepharoptosis 36 | 231
Intellectual disability 35 | 1,016
Mitochondrial complex I deficiency 35 | 46
adult high grade glioma 35 | 3,801
Kidney cancer 33 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
Acidosis, Lactic 31 | 97
Lactic acidemia 31 | 95
Muscle Weakness 31 | 170
Nystagmus 31 | 317
Sensorineural Hearing Loss (disorder) 31 | 284
Strabismus 31 | 270
Dull intelligence 30 | 645
Low intelligence 30 | 645
Mental Retardation 30 | 645
Mental deficiency 30 | 645
Obesity 30 | 678
Poor school performance 30 | 645
oligodendroglioma 28 | 2,850
Failure to gain weight 27 | 365
Pediatric failure to thrive 27 | 365
invasive ductal carcinoma 27 | 2,951
primitive neuroectodermal tumor 27 | 3,035
Highly variable clinical phenotype 25 | 150
Highly variable phenotype and severity 25 | 150
Highly variable phenotype, even within families 25 | 150
Hyperreflexia 25 | 209
Phenotypic variability 25 | 150
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
ulcerative colitis 25 | 1,819
Feeding difficulties in infancy 24 | 175
Mitochondrial Complex 1 Deficiency 24 | 28
Schizophrenia 24 | 1,160
Short stature 24 | 531
astrocytoma 24 | 1,146
breast carcinoma 24 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
malignant mesothelioma 24 | 3,232
Dystonia 23 | 164
Hypertrophic Cardiomyopathy 23 | 117
Muscle Spasticity 23 | 195
Optic Atrophy 23 | 242
Pick disease 23 | 1,894
Respiratory Failure 23 | 104
Developmental regression 22 | 95
Leigh syndrome 22 | 28
Loss of developmental milestones 22 | 95
Mental deterioration in childhood 22 | 95
Neurodevelopmental regression 22 | 95
Psychomotor regression 22 | 95
Psychomotor regression beginning in infancy 22 | 95
Psychomotor regression in infants 22 | 95
Psychomotor regression, progressive 22 | 95
group 4 medulloblastoma 22 | 1,855
non-small cell lung cancer 22 | 2,890
pancreatic cancer 22 | 2,398
pituitary cancer 22 | 1,972
Astrocytoma, Pilocytic 21 | 3,081
CSF lactate increased 21 | 33
Dystonic disease 21 | 106
Increased serum lactate 21 | 60
NADH:Q(1) Oxidoreductase deficiency 21 | 24
Waldenstrons macroglobulinemia 21 | 765
lung carcinoma 21 | 2,843
Hypoglycemia 20 | 152
subependymal giant cell astrocytoma 20 | 2,287
Abnormal mitochondria in muscle tissue 19 | 20
ductal carcinoma in situ 19 | 1,745
lung adenocarcinoma 19 | 2,716
Depressive disorder 18 | 409
Neurogenic Muscular Atrophy 18 | 139
Skeletal muscle atrophy 18 | 139
muscle degeneration 18 | 139

Tissue

Endocrine System 229 | 18,159
Digestive Tract 226 | 17,369
Female tissues 226 | 17,400
Liver and Pancreas 226 | 16,750
Skin and soft tissues 226 | 17,230
Male tissues 224 | 17,142
Nervous System 224 | 16,725
Blood and immune system 223 | 16,909
Cardiovascular System 223 | 15,192
Urinary Tract 222 | 16,678
Respiratory system 220 | 16,393

Target Family

Enzyme 138 | 4,145
Non-IDG 42 | 12,091
Kinase 24 | 634
Transcription Factor 12 | 1,400
Epigenetic 8 | 242
TF/Epigenetic 3 | 38
GPCR 2 | 408
Transporter 2 | 473
Nuclear Receptor 1 | 48

KEGG Pathway

Thermogenesis 232 | 232
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability