Development Level

Tbio 275 | 11,445
Tdark 54 | 6,588
Tchem 11 | 1,598

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 51 | 979
embryonic lethality prior to o... 18 | 239
embryonic lethality prior to t... 16 | 278
abnormal behavior 7 | 298
abnormal embryo size 7 | 220
preweaning lethality, incomple... 7 | 499
embryonic growth retardation 6 | 106
increased startle reflex 5 | 112
enlarged heart 4 | 210
hyperactivity 4 | 148
hypoactivity 4 | 132
increased fasted circulating g... 4 | 76
increased mean corpuscular vol... 4 | 92
abnormal coat-hair pigmentatio... 3 | 64
abnormal sleep behavior 3 | 70
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 31
decreased neutrophil cell numb... 3 | 42
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased lean body mass 3 | 172
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased mean platelet volume 3 | 45
prenatal lethality prior to he... 3 | 87
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal pericardium morpholog... 2 | 26
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 46
decreased circulating glucose ... 2 | 126
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
impaired righting response 2 | 26
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased grip strength 2 | 41
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
male infertility 2 | 123
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal esophagus morphology 1 | 5
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal pancreas morphology 1 | 13
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased IgE level 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased urine magnesium leve... 1 | 3
edema 1 | 59
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
pale yolk sac 1 | 25
pallor 1 | 34
short tibia 1 | 97
small kidney 1 | 16
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 228 | 11,493
ovarian cancer 221 | 8,520
osteosarcoma 172 | 7,950
medulloblastoma, large-cell 123 | 6,241
group 3 medulloblastoma 119 | 4,104
psoriasis 111 | 6,694
glioblastoma 104 | 5,792
lung cancer 102 | 4,740
atypical teratoid / rhabdoid tumor 93 | 5,112
ependymoma 91 | 4,679
oligodendroglioma 73 | 2,850
primitive neuroectodermal tumor 70 | 3,035
Multiple myeloma 68 | 1,332
acute quadriplegic myopathy 63 | 1,158
adult high grade glioma 59 | 3,801
astrocytic glioma 57 | 2,597
malignant mesothelioma 56 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,989
Breast cancer 53 | 3,578
Kidney cancer 50 | 2,613
Pick disease 49 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 49 | 2,955
dermatomyositis 44 | 966
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
astrocytoma 41 | 1,146
juvenile dermatomyositis 41 | 1,187
Waldenstrons macroglobulinemia 40 | 765
diabetes mellitus 40 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
non-small cell lung cancer 36 | 2,890
subependymal giant cell astrocytoma 35 | 2,287
lung adenocarcinoma 34 | 2,716
Astrocytoma, Pilocytic 32 | 3,081
invasive ductal carcinoma 32 | 2,951
progressive supranuclear palsy 31 | 676
Intellectual disability 30 | 1,016
pancreatic cancer 27 | 2,398
Cancer 24 | 2,499
group 4 medulloblastoma 24 | 1,855
acute myeloid leukemia 23 | 783
pediatric high grade glioma 23 | 1,064
Rheumatoid arthritis 22 | 1,191
pituitary cancer 21 | 1,972
Amyotrophic lateral sclerosis 19 | 451
breast carcinoma 19 | 1,638
non primary Sjogren syndrome sicca 18 | 891
tuberculosis and treatment for 6 months 18 | 409
colon cancer 17 | 1,478
Gaucher disease type 1 16 | 180
Muscular atrophy 16 | 71
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
aldosterone-producing adenoma 15 | 665
Schizophrenia 14 | 1,160
Spinal muscular atrophy 14 | 34
hepatocellular carcinoma 14 | 547
lung carcinoma 14 | 2,843
nasopharyngeal carcinoma 14 | 1,058
spina bifida 14 | 1,074
atypical teratoid/rhabdoid tumor 13 | 357
tuberculosis 13 | 2,010
cystic fibrosis 12 | 1,696
primary pancreatic ductal adenocarcinoma 12 | 1,109
Epilepsy 11 | 792
adrenocortical carcinoma 11 | 1,428
Alzheimer's disease 10 | 658
Autosomal recessive predisposition 10 | 1,442
Broad flat nasal bridge 10 | 236
Cognitive delay 10 | 608
Conductive hearing loss 10 | 123
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Microcephaly 10 | 166
Nasal bridge wide 10 | 236
Neurodegenerative disease 10 | 414
Anteverted nostril 9 | 191
Duchenne muscular dystrophy 9 | 601
Melanoma 9 | 711
Nystagmus 9 | 317
Polycystic ovary syndrome 9 | 360
Small head 9 | 374
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
ductal carcinoma in situ 9 | 1,745
primary Sjogren syndrome 9 | 735
sonic hedgehog group medulloblastoma 9 | 467
Cleft Palate 8 | 271
Hypogonadism 8 | 173
Obesity 8 | 678
Retinitis Pigmentosa 8 | 226
Short stature 8 | 531
Uranostaphyloschisis 8 | 167
gastric cancer 8 | 459
hereditary spastic paraplegia 8 | 318
medulloblastoma 8 | 720
pancreatic carcinoma 8 | 562
posterior fossa group B ependymoma 8 | 416
ulcerative colitis 8 | 1,819

Tissue

Endocrine System 337 | 18,159
Digestive Tract 332 | 17,369
Female tissues 332 | 17,400
Skin and soft tissues 331 | 17,230
Male tissues 330 | 17,142
Nervous System 329 | 16,725
Respiratory system 328 | 16,393
Urinary Tract 328 | 16,678
Liver and Pancreas 327 | 16,750
Blood and immune system 326 | 16,909
Cardiovascular System 325 | 15,192

Target Family

Non-IDG 263 | 12,091
Enzyme 61 | 4,145
Kinase 6 | 634
Epigenetic 5 | 242
Transcription Factor 5 | 1,400

UniProt Keyword

mRNA processing 340 | 340
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pre-mRNA-splicing factor 18 PRPF18 Tbio Non-IDG -1.36183 19.8 84
U6 snRNA-associated Sm-like protein LSm2 LSM2 Tbio Non-IDG -1.40226 23.0 121
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
THO complex subunit 6 homolog THOC6 Tbio Non-IDG -1.77416 57.9 131
Transcription elongation factor SPT6 SUPT6H Tbio Non-IDG -1.80696 66.9 123
Putative C->U-editing enzyme APOBEC-4 APOBEC4 Tdark Non-IDG -0.53411 2.24 183
U6 snRNA-associated Sm-like protein LSm8 LSM8 Tdark Non-IDG -0.82004 6.23 34
Pre-mRNA-splicing factor SYF1 XAB2 Tbio Non-IDG -1.02890 12.5 247
U6 snRNA-associated Sm-like protein LSm4 LSM4 Tbio Non-IDG -2.13782 132.0 149
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.74929 55.5 106