Development Level

Tbio 1,217 | 10,625
Tdark 831 | 7,003
Tchem 229 | 1,890
Tclin 63 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 69 | 633
preweaning lethality, incomple... 40 | 260
decreased body weight 28 | 174
decreased total body fat amoun... 27 | 186
abnormal behavior 26 | 226
decreased lean body mass 21 | 195
embryonic lethality prior to t... 18 | 187
hypoactivity 16 | 89
decreased grip strength 15 | 123
hyperactivity 15 | 108
decreased body length 14 | 108
decreased bone mineral density 14 | 126
short tibia 14 | 82
abnormal bone structure 13 | 131
abnormal retina morphology 13 | 100
embryonic lethality prior to o... 13 | 148
increased bone mineral content 13 | 92
abnormal embryo size 12 | 112
decreased circulating glucose ... 12 | 121
increased or absent threshold ... 12 | 128
abnormal bone mineralization 11 | 55
decreased bone mineral content 11 | 157
enlarged heart 11 | 111
increased lean body mass 11 | 107
increased sacral vertebrae num... 11 | 62
decreased circulating serum al... 10 | 79
increased circulating choleste... 10 | 53
prenatal lethality prior to he... 10 | 64
decreased circulating choleste... 9 | 85
increased circulating HDL chol... 9 | 63
increased circulating alkaline... 9 | 119
increased mean corpuscular vol... 9 | 91
decreased circulating HDL chol... 8 | 77
decreased hemoglobin content 8 | 53
decreased prepulse inhibition 8 | 52
abnormal coat/hair pigmentatio... 7 | 54
abnormal gait 7 | 51
abnormal retinal pigmentation 7 | 61
decreased caudal vertebrae num... 7 | 49
decreased circulating alanine ... 7 | 53
decreased circulating triglyce... 7 | 83
decreased heart weight 7 | 44
decreased lumbar vertebrae num... 7 | 62
decreased rib number 7 | 59
increased circulating creatini... 7 | 29
increased fasted circulating g... 7 | 68
increased mean corpuscular hem... 7 | 93
male infertility 7 | 62
abnormal eye morphology 6 | 38
abnormal heart morphology 6 | 51
abnormal spleen morphology 6 | 36
decreased circulating LDL chol... 6 | 37
decreased circulating chloride... 6 | 32
decreased circulating total pr... 6 | 41
increased bone mineral density 6 | 52
increased circulating triglyce... 6 | 24
increased exploration in new e... 6 | 56
increased monocyte cell number 6 | 27
limb grasping 6 | 35
abnormal behavioral response t... 5 | 52
abnormal cornea morphology 5 | 24
abnormal lens morphology 5 | 73
abnormal neural tube closure 5 | 37
decreased CD4-positive, CD25-p... 5 | 24
decreased blood urea nitrogen ... 5 | 31
decreased circulating alkaline... 5 | 41
decreased circulating free fat... 5 | 39
decreased circulating insulin ... 5 | 75
decreased leukocyte cell numbe... 5 | 54
decreased mean corpuscular hem... 5 | 34
decreased mean corpuscular vol... 5 | 50
female infertility 5 | 34
hydrops fetalis 5 | 22
increased body weight 5 | 42
increased grip strength 5 | 83
increased heart weight 5 | 37
increased hematocrit 5 | 36
increased startle reflex 5 | 38
increased total body fat amoun... 5 | 57
abnormal heart left ventricle ... 4 | 20
abnormal kidney morphology 4 | 30
abnormal locomotor activation 4 | 26
abnormal sleep behavior 4 | 63
abnormal vertebrae morphology 4 | 14
corneal opacity 4 | 25
decreased circulating aspartat... 4 | 27
decreased circulating fructosa... 4 | 31
decreased eosinophil cell numb... 4 | 41
decreased neutrophil cell numb... 4 | 37
decreased vertical activity 4 | 22
enlarged spleen 4 | 26
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased body length 4 | 20
increased circulating chloride... 4 | 43
increased circulating iron lev... 4 | 25
increased circulating sodium l... 4 | 71
increased hemoglobin content 4 | 45
straub tail 4 | 26
thrombocytopenia 4 | 46

Disease

osteosarcoma 1,148 | 7,933
ovarian cancer 1,095 | 8,484
medulloblastoma, large-cell 781 | 6,234
psoriasis 729 | 6,685
glioblastoma 666 | 5,572
atypical teratoid / rhabdoid tumor 559 | 4,369
lung cancer 539 | 4,466
primitive neuroectodermal tumor 421 | 3,031
malignant mesothelioma 413 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 390 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 361 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 359 | 2,988
Breast cancer 354 | 3,094
oligodendroglioma 353 | 2,849
Carcinoma 348 | 2,147
group 4 medulloblastoma 325 | 1,875
group 3 medulloblastoma 322 | 2,254
ependymoma 318 | 2,514
invasive ductal carcinoma 307 | 2,950
Cancer 301 | 2,346
pilocytic astrocytoma 300 | 3,086
pediatric high grade glioma 298 | 2,712
lung carcinoma 281 | 2,844
non-small cell lung cancer 281 | 2,798
subependymal giant cell astrocytoma 274 | 2,287
astrocytic glioma 257 | 2,241
pancreatic cancer 257 | 2,300
adult high grade glioma 253 | 2,148
lung adenocarcinoma 247 | 2,713
Pick disease 237 | 1,893
ulcerative colitis 222 | 2,087
interstitial cystitis 212 | 2,299
astrocytoma 203 | 1,493
pituitary cancer 201 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 186 | 1,795
sonic hedgehog group medulloblastoma 185 | 1,482
breast carcinoma 182 | 1,614
medulloblastoma 181 | 1,524
tuberculosis 181 | 1,557
cystic fibrosis 180 | 1,665
adrenocortical carcinoma 179 | 1,427
ductal carcinoma in situ 178 | 1,745
juvenile dermatomyositis 175 | 1,189
spina bifida 160 | 1,064
primary pancreatic ductal adenocarcinoma 156 | 1,271
colon cancer 152 | 1,475
acute quadriplegic myopathy 150 | 1,157
Rheumatoid Arthritis 149 | 1,160
posterior fossa group A ependymoma 142 | 1,511
posterior fossa group B ependymoma 141 | 1,530
diabetes mellitus 137 | 1,663
Multiple myeloma 134 | 1,327
atypical teratoid/rhabdoid tumor 132 | 1,095
dermatomyositis 116 | 933
tuberculosis and treatment for 6 months 116 | 686
acute myeloid leukemia 114 | 780
cutaneous lupus erythematosus 112 | 1,056
active Crohn's disease 110 | 918
non primary Sjogren syndrome sicca 104 | 840
Atopic dermatitis 100 | 944
progressive supranuclear palsy 95 | 674
nasopharyngeal carcinoma 92 | 1,056
primary Sjogren syndrome 91 | 789
gastric carcinoma 86 | 832
Intellectual disability 83 | 573
esophageal adenocarcinoma 80 | 737
hepatocellular carcinoma 77 | 532
Alzheimer's disease 75 | 644
aldosterone-producing adenoma 74 | 664
Amyotrophic Lateral Sclerosis 72 | 431
gastric cancer 72 | 430
Waldenstrons macroglobulinemia 71 | 765
Endometriosis 67 | 535
Mammary Neoplasms 67 | 410
Down syndrome 63 | 548
pancreatic carcinoma 62 | 567
Prostatic Neoplasms 59 | 471
active ulcerative colitis 59 | 477
Schizophrenia 56 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 55 | 499
chronic rhinosinusitis 54 | 512
Acquired metabolic disease 52 | 267
Duchenne muscular dystrophy 51 | 602
glioblastoma multiforme 51 | 347
Multiple Sclerosis 50 | 498
mucosa-associated lymphoid tissue lymphoma 50 | 480
Obesity 49 | 616
fibroadenoma 47 | 557
inflammatory breast cancer 46 | 404
sarcoidosis 46 | 358
facioscapulohumeral dystrophy 43 | 286
Neurodegenerative disease 42 | 383
Stomach Neoplasms 41 | 282
Heart disease 40 | 279
Crohn's disease 38 | 304
IGA Glomerulonephritis 38 | 454
interstitial lung disease 38 | 291
hereditary spastic paraplegia 37 | 313
Autistic Disorder 36 | 320
Asthma 35 | 349

Tissue

Nervous System 2,271 | 18,561
Female tissues 2,265 | 18,647
Endocrine System 2,260 | 18,512
Digestive Tract 2,259 | 18,473
Urinary Tract 2,258 | 18,444
Liver and Pancreas 2,249 | 18,136
Blood and immune system 2,241 | 17,995
Cardiovascular System 2,239 | 17,958
Male tissues 2,238 | 17,969
Skin and soft tissues 2,232 | 18,115
Respiratory system 2,203 | 17,484

Target Family

Transcription Factor 745 | 1,400
Non-IDG 728 | 11,971
Enzyme 580 | 4,146
Epigenetic 129 | 242
Nuclear Receptor 46 | 48
Kinase 42 | 634
TF/Epigenetic 30 | 38
Transporter 25 | 473
Ion Channel 13 | 341
GPCR 2 | 406

UniProt Keyword

Zinc 2,340 | 2,340
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Zinc finger CCHC domain-containing protein 16 ZCCHC16 Tdark Non-IDG -1.29964 20.8 7
Zinc finger protein GLIS1 GLIS1 Tbio Transcription Factor -0.87828 10.0 91
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062