Development Level

Tbio 16 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
decreased bone mineral density 1 | 126
decreased fasted circulating g... 1 | 65
embryonic lethality prior to o... 1 | 239
increased bone mineral density 1 | 72
increased fasted circulating g... 1 | 76
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 14 | 11,493
ovarian cancer 12 | 8,520
osteosarcoma 10 | 7,950
lung cancer 7 | 4,740
Breast cancer 6 | 3,578
ependymoma 6 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
psoriasis 6 | 6,694
acute quadriplegic myopathy 5 | 1,158
group 3 medulloblastoma 5 | 4,104
medulloblastoma, large-cell 5 | 6,241
non-small cell lung cancer 5 | 2,890
Kidney cancer 4 | 2,613
glioblastoma 4 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
primitive neuroectodermal tumor 4 | 3,035
atypical teratoid / rhabdoid tumor 3 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung adenocarcinoma 3 | 2,716
pediatric high grade glioma 3 | 1,064
Disease Progression 2 | 136
Gaucher disease type 1 2 | 180
Male infertility 2 | 206
Stomach Neoplasms 2 | 300
aldosterone-producing adenoma 2 | 665
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
group 4 medulloblastoma 2 | 1,855
hepatocellular carcinoma 2 | 547
juvenile dermatomyositis 2 | 1,187
oligodendroglioma 2 | 2,850
subependymal giant cell astrocytoma 2 | 2,287
Abnormality of the pharynx 1 | 19
Acute Promyelocytic Leukemia 1 | 40
Adenocarcinoma of lung 1 | 142
Adult onset 1 | 82
Alzheimer's disease 1 | 658
Amebiasis 1 | 21
Asthenopia 1 | 10
Bell Palsy 1 | 58
Blepharoptosis 1 | 231
Cataract 4 multiple types 1 | 14
Constipation 1 | 181
Creatine phosphokinase serum increased 1 | 110
Deglutition Disorders 1 | 132
Disease Models, Animal 1 | 155
Distal limb muscle weakness due to peripheral neuropathy 1 | 62
Distal muscle weakness 1 | 62
Dysarthria 1 | 192
Dyspepsia 1 | 33
Elevated creatine kinase 1 | 110
Endomyocardial Fibrosis 1 | 13
Facial Paresis 1 | 59
Facial muscle weakness of muscles innervated by CN VII 1 | 58
Hepatitis B 1 | 108
Hypereosinophilic syndrome 1 | 71
Infertility 1 | 188
Influenza 1 | 142
Kidney disease 1 | 430
Leukemia 1 | 104
Liver cancer 1 | 604
Mask-like facies 1 | 25
Mastocytosis 1 | 27
Mucoepidermoid carcinoma 1 | 26
Muscle weakness of limb 1 | 21
Muscular dystrophy 1 | 75
Myopathy 1 | 185
Neck muscle weakness 1 | 17
Ophthalmoplegia 1 | 106
Pick disease 1 | 1,894
Pneumonia 1 | 174
Polycythemia vera 1 | 27
Progressive disorder 1 | 142
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Ptosis 1 | 48
Rectal prolapse 1 | 19
Rift Valley fever 1 | 14
Severe acute respiratory syndrome 1 | 27
Waldenstrons macroglobulinemia 1 | 765
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
chronic rhinosinusitis 1 | 512
colon cancer 1 | 1,478
cystic fibrosis and chronic rhinosinusitis 1 | 214
dermatomyositis 1 | 966
interstitial lung disease 1 | 298
medulloblastoma 1 | 720
nasopharyngeal carcinoma 1 | 1,058
pancreatic cancer 1 | 2,398
pancreatic carcinoma 1 | 562
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pituitary cancer 1 | 1,972
posterior fossa group B ependymoma 1 | 416
primary pancreatic ductal adenocarcinoma 1 | 1,109
sarcoidosis 1 | 370
spina bifida 1 | 1,074
tuberculosis 1 | 2,010
tuberculosis and treatment for 3 months 1 | 179

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Non-IDG 17 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Processing of Intronless Pre-m... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(A) polymerase alpha PAPOLA Tbio Enzyme -0.76388 5.75 90
Cleavage stimulation factor subunit 2 tau variant CSTF2T Tbio Non-IDG -0.87334 8.94 128
Cleavage and polyadenylation specificity factor subunit 5 NUDT21 Tbio Non-IDG -1.56364 34.0 119
Nuclear cap-binding protein subunit 2 NCBP2 Tbio Non-IDG -1.45099 24.2 110
Cleavage stimulation factor subunit 1 CSTF1 Tbio Non-IDG -0.87822 6.45 157
Cleavage stimulation factor subunit 2 CSTF2 Tbio Non-IDG -1.71269 46.9 271
Cleavage and polyadenylation specificity factor subunit 2 CPSF2 Tbio Non-IDG -1.08859 10.1 74
Cleavage and polyadenylation specificity factor subunit 4 CPSF4 Tbio Non-IDG -2.46363 285.6 154