Development Level

Tbio 51 | 11,445
Tchem 14 | 1,598
Tdark 5 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased bone mineral content 3 | 108
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased fasted circulating g... 2 | 65
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased cardiac output 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged thymus 1 | 5
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased glycosylated hemoglo... 1 | 1
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
long tibia 1 | 25
narrow eye opening 1 | 12
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QRS complex duration 1 | 8
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 50 | 11,493
osteosarcoma 48 | 7,950
ovarian cancer 39 | 8,520
medulloblastoma, large-cell 34 | 6,241
glioblastoma 32 | 5,792
psoriasis 29 | 6,694
atypical teratoid / rhabdoid tumor 26 | 5,112
adult high grade glioma 25 | 3,801
lung cancer 25 | 4,740
Cancer 22 | 2,499
group 3 medulloblastoma 20 | 4,104
ependymoma 18 | 4,679
primitive neuroectodermal tumor 18 | 3,035
astrocytic glioma 15 | 2,597
malignant mesothelioma 15 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Kidney cancer 13 | 2,613
Multiple myeloma 13 | 1,332
Pick disease 13 | 1,894
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 12 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Breast cancer 11 | 3,578
Obesity 11 | 678
diabetes mellitus 11 | 1,728
invasive ductal carcinoma 11 | 2,951
Schizophrenia 10 | 1,160
subependymal giant cell astrocytoma 10 | 2,287
group 4 medulloblastoma 9 | 1,855
pituitary cancer 9 | 1,972
Waldenstrons macroglobulinemia 8 | 765
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
non-small cell lung cancer 8 | 2,890
tuberculosis 8 | 2,010
Parkinson's disease 7 | 392
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
Breast Neoplasms 6 | 445
Cardiomegaly 6 | 116
Cardiomyopathies 6 | 110
Mammary Neoplasms 6 | 425
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
acute quadriplegic myopathy 6 | 1,158
interstitial cystitis 6 | 2,312
lung adenocarcinoma 6 | 2,716
Alzheimer's disease 5 | 658
Bipolar Disorder 5 | 666
Depressive disorder 5 | 409
Endometriosis 5 | 540
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Muscle hypotonia 5 | 571
Seizures 5 | 596
breast carcinoma 5 | 1,638
ulcerative colitis 5 | 1,819
Diabetes Mellitus, Experimental 4 | 108
Fatty Liver 4 | 70
Fatty liver disease 4 | 103
Hyperglycemia 4 | 137
Liver neoplasms 4 | 130
Myocardial Infarction 4 | 151
acute myeloid leukemia 4 | 783
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
atypical teratoid/rhabdoid tumor 4 | 357
gastric carcinoma 4 | 807
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
Atherosclerosis 3 | 291
Autistic Disorder 3 | 364
Bladder Neoplasm 3 | 112
Carcinoma, Hepatocellular 3 | 228
Chronic progressive external ophthalmoplegia 3 | 26
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Disease Progression 3 | 136
Down syndrome 3 | 499
Heart disease 3 | 306
Huntington's disease 3 | 76
Hypoglycemia 3 | 152
Liver carcinoma 3 | 240
Mental Depression 3 | 333
Mesothelioma, Malignant 3 | 105
Methylmalonic acidemia 3 | 37
Myocardial Ischemia 3 | 169
Myopathy 3 | 185
Neuropathy 3 | 261
Peripheral T-cell lymphoma 3 | 25
Primary cutaneous T-cell lymphoma 3 | 29
Urinary Bladder Neoplasms 3 | 114
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group A ependymoma 3 | 468
posterior fossa group B ependymoma 3 | 416

Tissue

Cardiovascular System 74 | 15,192
Digestive Tract 74 | 17,369
Endocrine System 74 | 18,159
Male tissues 74 | 17,142
Skin and soft tissues 74 | 17,230
Female tissues 73 | 17,400
Urinary Tract 73 | 16,678
Blood and immune system 72 | 16,909
Liver and Pancreas 72 | 16,750
Nervous System 72 | 16,725
Respiratory system 72 | 16,393

Target Family

Non-IDG 29 | 12,091
Enzyme 18 | 4,145
Epigenetic 8 | 242
Transcription Factor 8 | 1,400
Kinase 7 | 634
Nuclear Receptor 4 | 48

Reactome Pathway

Mitochondrial biogenesis 74 | 74
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting and assembly machinery component 50 homolog SAMM50 Tbio Non-IDG -2.09079 120.9 124
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.35771 201.5 23
Cytochrome c CYCS Tbio Non-IDG -3.76637 4945.6 833
Chromodomain-helicase-DNA-binding protein 9 CHD9 Tbio Epigenetic -0.90481 7.77 30
GA-binding protein alpha chain GABPA Tbio Transcription Factor -1.50283 31.7 289
PGC-1 and ERR-induced regulator in muscle protein 1 PERM1 Tdark Non-IDG -0.48311 2.91 21
MICOS complex subunit MIC60 IMMT Tbio Non-IDG -2.81178 611.6 222
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148
ATP synthase subunit a MT-ATP6 Tbio Enzyme -2.74832 542.1 40
Isocitrate dehydrogenase [NADP], mitochondrial IDH2 Tclin Enzyme -2.94039 813.3 296