Development Level

Tbio 29 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 3 | 220
embryonic lethality prior to o... 3 | 239
abnormal body wall morphology 2 | 9
hypoactivity 2 | 132
abnormal behavior 1 | 298
abnormal craniofacial morpholo... 1 | 33
abnormal kidney morphology 1 | 65
abnormal retinal inner nuclear... 1 | 8
abnormal skin morphology 1 | 50
decreased circulating free fat... 1 | 31
decreased total retina thickne... 1 | 17
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
prenatal lethality prior to he... 1 | 87
protruding tongue 1 | 3

Disease

ovarian cancer 22 | 8,520
psoriasis 11 | 6,694
osteosarcoma 9 | 7,950
Carcinoma 8 | 11,493
Multiple myeloma 8 | 1,332
lung cancer 7 | 4,740
medulloblastoma, large-cell 7 | 6,241
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
progressive supranuclear palsy 4 | 676
Breast cancer 3 | 3,578
acute myeloid leukemia 3 | 783
adult high grade glioma 3 | 3,801
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
tuberculosis 3 | 2,010
Anemia 2 | 365
Cancer 2 | 2,499
Chronic Lymphocytic Leukemia 2 | 262
Kaposi's sarcoma 2 | 22
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Neurodegenerative disease 2 | 414
Pick disease 2 | 1,894
Pick's disease 2 | 15
aldosterone-producing adenoma 2 | 665
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
group 3 medulloblastoma 2 | 4,104
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
pancreatic cancer 2 | 2,398
primary Sjogren syndrome 2 | 735
ulcerative colitis 2 | 1,819
Apathy 1 | 16
Aphasia 1 | 26
Apraxias 1 | 27
Autosomal dominant Robinow syndrome 1 1 | 15
Autosomal recessive Robinow syndrome 1 | 27
Behavioral variant of frontotemporal dementia 1 | 8
CATARACT 16, MULTIPLE TYPES 1 | 15
Cleft uvula 1 | 27
Compulsive hoarding 1 | 7
Danon disease 1 | 8
Deglutition Disorders 1 | 132
Dentin dysplasia 1 | 19
Developmental arithmetic disorder 1 | 8
Dysgraphia 1 | 20
Dyslexia 1 | 43
Dysphasia 1 | 23
Dyspnea 1 | 76
Echolalia 1 | 12
Excess nuchal skin 1 | 30
Familial cancer of breast 1 | 12
Forgetful 1 | 40
Frontal release signs 1 | 3
Frontotemporal cerebral atrophy 1 | 8
Human immunodeficiency virus infectious disease 1 | 138
Hyperorality 1 | 7
Idiopathic scoliosis 1 | 31
Intermediate coronary syndrome 1 | 11
Irritation - emotion 1 | 68
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Memory Loss 1 | 40
Memory impairment 1 | 40
Muscle Cramp 1 | 55
Muscle Rigidity 1 | 49
Muscular fasciculation 1 | 22
Mutism 1 | 17
Myoclonus 1 | 74
Neuro-degenerative disease 1 | 43
Neurodegenerative Disorders 1 | 79
Ovarian Neoplasms 1 | 102
Pain 1 | 103
Paralysed 1 | 42
Poor speech 1 | 37
Problems speaking 1 | 37
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Respiratory insufficiency due to muscle weakness 1 | 37
Restlessness 1 | 14
Restrictive behavior, interests, and activities 1 | 7
Social disinhibition 1 | 14
Submucous cleft of hard palate 1 | 11
Williams-Beuren syndrome 1 | 50
Xerostomia 1 | 42
lingual-facial-buccal dyskinesia 1 | 13
ovarian neoplasm 1 | 99
primary open angle glaucoma 1 | 16

Tissue

Blood and immune system 30 | 16,909
Cardiovascular System 30 | 15,192
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678

Target Family

Non-IDG 29 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Endosomal Sorting Complex Requ... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 4b CHMP4B Tbio Non-IDG -0.64678 4.55 106
Charged multivesicular body protein 6 CHMP6 Tbio Non-IDG -1.35757 22.3 120
Vacuolar protein-sorting-associated protein 25 VPS25 Tbio Non-IDG -1.21447 17.7 154
Vacuolar protein-sorting-associated protein 36 VPS36 Tbio Non-IDG -1.28926 19.8 35
Vacuolar protein sorting-associated protein 28 homolog VPS28 Tbio Non-IDG -1.29153 15.5 110
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
Ubiquitin-associated protein 1 UBAP1 Tbio Non-IDG -2.22105 163.3 130
Charged multivesicular body protein 5 CHMP5 Tbio Non-IDG -1.35804 24.3 157
Vacuolar protein sorting-associated protein 4A VPS4A Tbio Non-IDG -1.69610 49.5 94
Vacuolar protein sorting-associated protein 37A VPS37A Tbio Non-IDG -0.85697 9.69 80