Development Level

Tbio 13 | 10,625
Tchem 11 | 1,890

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 3 | 148
abnormal embryo size 2 | 112
embryonic lethality prior to t... 2 | 187
increased circulating alkaline... 2 | 119
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal spinal cord morpholog... 1 | 8
cataract 1 | 26
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
impaired glucose tolerance 1 | 52
increased erythrocyte cell num... 1 | 26
increased red blood cell distr... 1 | 21
increased thermal nociceptive ... 1 | 9

Disease

ovarian cancer 21 | 8,491
Multiple myeloma 13 | 1,327
lung cancer 11 | 4,473
psoriasis 11 | 6,685
glioblastoma 8 | 5,572
medulloblastoma, large-cell 8 | 6,234
Cancer 7 | 2,346
astrocytoma 7 | 1,493
Charcot-Marie-Tooth disease 6 | 74
Neurodegenerative disease 6 | 383
Neuropathy 6 | 210
colon cancer 6 | 1,475
dermatomyositis 6 | 966
diabetes mellitus 6 | 1,663
Waldenstrons macroglobulinemia 5 | 764
juvenile dermatomyositis 5 | 1,189
osteosarcoma 5 | 7,933
sonic hedgehog group medulloblastoma 5 | 1,482
Epilepsy 4 | 346
Myositis 4 | 24
Pick disease 4 | 1,893
acute quadriplegic myopathy 4 | 1,157
non-small cell lung cancer 4 | 2,798
Breast cancer 3 | 3,098
acute myeloid leukemia 3 | 785
lung adenocarcinoma 3 | 2,714
non primary Sjogren syndrome sicca 3 | 840
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
Carcinoma 2 | 2,147
Leukodystrophy 2 | 30
Subcutaneous panniculitis-like T-cell lymphoma 2 | 16
active Crohn's disease 2 | 918
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
chronic lymphocytic leukemia 2 | 244
ependymoma 2 | 2,514
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
invasive ductal carcinoma 2 | 2,950
malignant mesothelioma 2 | 3,163
medulloblastoma 2 | 1,524
primary pancreatic ductal adenocarcinoma 2 | 1,271
primitive neuroectodermal tumor 2 | 3,031
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
tuberculosis and treatment for 6 months 2 | 686
Alcohol dependence 1 | 107
Anemia 1 | 252
Atypical autism 1 | 25
Basal ganglia calcification 1 | 17
Binder syndrome 1 | 3
Charcot-Marie-Tooth Disease, Dominant Intermediate C 1 | 1
Charcot-Marie-Tooth disease 2D 1 | 1
Charcot-Marie-Tooth disease, Type 2D 1 | 1
Charcot-Marie-Tooth disease, dominant, intermediate type, C 1 | 1
Childhood disintegrative disease 1 | 4
Cholera 1 | 33
Common cold 1 | 63
Cowpox 1 | 15
Dyschromatosis symmetrica hereditaria 1 | 3
Endophthalmitis 1 | 10
Filariasis 1 | 21
Friedreich ataxia 1 | 23
Gaucher disease type 1 1 | 171
Glycine encephalopathy 1 | 28
Herpes zoster 1 | 7
Homocystinuria 1 | 23
Hyperhomocysteinemia 1 | 34
Impetigo 1 | 9
Inflammatory myofibroblastic tumor 1 | 8
Larsen syndrome 1 | 11
MYELODYSPLASTIC SYNDROME 1 | 39
Methicillin-Resistant Staphylococcus Aureus Nasal Colonization 1 | 1
Muscular atrophy 1 | 67
Neuritis 1 | 6
Neuronopathy, distal hereditary motor, 5A 1 | 2
Nonsyndromic deafness 1 | 121
Patellofemoral pain syndrome 1 | 9
Pulmonary alveolar proteinosis 1 | 13
Q fever 1 | 11
Renal Cell Carcinoma 1 | 199
Retinal detachment 1 | 33
Retinitis pigmentosa 1 | 156
Scrapie 1 | 16
Sleeping sickness 1 | 37
Staph Aureus Traumatic Skin Lesion Infection 1 | 1
Theileriasis 1 | 13
Thymic dysplasia 1 | 2
Toxocariasis 1 | 6
Traumatic Skin Lesion Streptococcus Pyogenes Infection 1 | 1
Variant Creutzfeldt-Jakob disease 1 | 17
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
interstitial lung disease 1 | 292
sarcoidosis 1 | 368

Tissue

Blood and immune system 24 | 17,994
Cardiovascular System 24 | 17,957
Digestive Tract 24 | 18,472
Endocrine System 24 | 18,511
Female tissues 24 | 18,646
Liver and Pancreas 24 | 18,135
Male tissues 24 | 17,968
Nervous System 24 | 18,560
Respiratory system 24 | 17,483
Skin and soft tissues 24 | 18,114
Urinary Tract 24 | 18,443

Target Family

Enzyme 23 | 4,146
Non-IDG 1 | 11,969

Reactome Pathway

Cytosolic tRNA aminoacylation 24 | 24
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.87551 70.7 111
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.35172 218.9 181
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -2.96440 867.8 123
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.44584 251.4 123
Asparagine--tRNA ligase, cytoplasmic NARS Tbio Enzyme -1.93102 87.4 110
Valine--tRNA ligase VARS Tchem Enzyme -1.95235 86.9 101
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.59977 386.1 114
Leucine--tRNA ligase, cytoplasmic LARS Tchem Enzyme -3.15180 1377.8 61
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.44185 264.5 157
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.06026 1084.2 75