Development Level

Tbio 33 | 11,651
Tchem 17 | 1,388
Tclin 11 | 612
Tdark 3 | 6,593

IMPC Phenotype

abnormal behavior 3 | 298
cataract 3 | 92
decreased total body fat amoun... 3 | 207
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal bone structure 2 | 187
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
hyperactivity 2 | 148
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
small kidney 2 | 16
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal male genitalia morpho... 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent external male genitalia 1 | 1
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased skeletal muscle mass 1 | 1
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
oligodactyly 1 | 1
polydactyly 1 | 7
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 53 | 11,493
psoriasis 32 | 6,694
Cancer 26 | 2,499
ovarian cancer 22 | 8,520
medulloblastoma, large-cell 21 | 6,241
osteosarcoma 21 | 7,950
lung cancer 20 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Prostatic Neoplasms 17 | 495
interstitial cystitis 16 | 2,312
Autosomal recessive predisposition 15 | 1,442
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
non-small cell lung cancer 13 | 2,890
Breast cancer 12 | 3,578
adult high grade glioma 12 | 3,801
lung carcinoma 12 | 2,843
malignant mesothelioma 12 | 3,232
Congenital adrenal hyperplasia 11 | 73
Hypertension 11 | 396
Liver disease 11 | 237
Chemical and Drug Induced Liver Injury 10 | 195
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
tuberculosis 10 | 2,010
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
adrenocortical carcinoma 9 | 1,428
ependymoma 9 | 4,679
group 3 medulloblastoma 9 | 4,104
pituitary cancer 9 | 1,972
Cholestasis 8 | 155
Osteoporosis 8 | 363
Schizophrenia 8 | 1,160
diabetes mellitus 8 | 1,728
lung adenocarcinoma 8 | 2,716
Astrocytoma, Pilocytic 7 | 3,081
Melanoma 7 | 711
Obesity 7 | 678
cystic fibrosis 7 | 1,696
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,951
pancreatic cancer 7 | 2,398
ulcerative colitis 7 | 1,819
Adenoma 6 | 167
Cushing's syndrome 6 | 48
Endometriosis 6 | 540
Epilepsy 6 | 792
Hypertensive disease 6 | 292
Kidney cancer 6 | 2,613
Lung Neoplasms 6 | 232
Polycystic ovary syndrome 6 | 360
active Crohn's disease 6 | 922
astrocytoma 6 | 1,146
chronic rhinosinusitis 6 | 512
cutaneous lupus erythematosus 6 | 1,057
oligodendroglioma 6 | 2,850
Adenocarcinoma 5 | 122
Adrenal cortical adenoma 5 | 19
Antley-Bixler syndrome 5 | 16
Cryptorchidism 5 | 296
Delayed bone age 5 | 136
Drug-Related Side Effects and Adverse Reactions 5 | 62
Failure to gain weight 5 | 365
Fatty Liver 5 | 70
Gynecomastia 5 | 64
Hyperaldosteronism 5 | 35
Hyperandrogenism 5 | 34
Liver Cirrhosis 5 | 181
Pediatric failure to thrive 5 | 365
Pick disease 5 | 1,894
Short stature 5 | 531
aldosterone-producing adenoma 5 | 665
breast carcinoma 5 | 1,638
group 4 medulloblastoma 5 | 1,855
medulloblastoma 5 | 720
Abortion, Spontaneous 4 | 109
Alcoholic Intoxication, Chronic 4 | 289
Atopic dermatitis 4 | 952
Atrial Fibrillation 4 | 124
Carcinoma, Hepatocellular 4 | 228
Colorectal Neoplasms 4 | 243
Depressive disorder 4 | 409
Hepatomegaly 4 | 285
Infertility 4 | 188
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Major Depressive Disorder 4 | 301
Malaria 4 | 160
Male infertility 4 | 206
Seizures 4 | 596
Spontaneous abortion 4 | 113
Tinea corporis 4 | 25
Tinea pedis 4 | 29
acute quadriplegic myopathy 4 | 1,158
head and neck cancer and chronic obstructive pulmonary disease 4 | 239
nephrosclerosis 4 | 333
substance-related disorder 4 | 162

Tissue

Endocrine System 61 | 18,159
Digestive Tract 60 | 17,369
Female tissues 59 | 17,400
Liver and Pancreas 58 | 16,750
Male tissues 57 | 17,142
Skin and soft tissues 57 | 17,230
Urinary Tract 54 | 16,678
Blood and immune system 53 | 16,909
Respiratory system 53 | 16,393
Nervous System 48 | 16,725
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 28 | 4,145
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Cytochrome P450 - arranged by ... 64 | 64
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.70628 492.9 68
Cytochrome P450 4B1 CYP4B1 Tbio Non-IDG -1.80695 66.9 104
Cytochrome P450 2J2 CYP2J2 Tchem Non-IDG -2.12012 148.8 194
Cytochrome P450 3A7 CYP3A7 Tclin Enzyme -1.97551 88.1 164
Cytochrome P450 2C9 CYP2C9 Tchem Non-IDG -3.21210 1623.8 177
Cytochrome P450 4V2 CYP4V2 Tbio Non-IDG -2.73252 534.7 128
Cytochrome P450 2A6 CYP2A6 Tchem Non-IDG -2.84002 705.5 272