Development Level

Tclin 29 | 602
Tbio 28 | 10,625
Tchem 21 | 1,890
Tdark 1 | 7,003

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 4 | 187
abnormal behavior 3 | 226
hyperactivity 3 | 108
decreased body weight 2 | 174
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
impaired glucose tolerance 2 | 52
increased or absent threshold ... 2 | 128
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal sensory capabilities/... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased prepulse inhibition 1 | 52
decreased pulmonary respirator... 1 | 4
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged heart 1 | 111
increased IgA level 1 | 1
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
small epididymis 1 | 3
straub tail 1 | 26
thrombocytopenia 1 | 46

Disease

psoriasis 43 | 6,685
ovarian cancer 38 | 8,484
glioblastoma 34 | 5,572
medulloblastoma, large-cell 34 | 6,234
osteosarcoma 29 | 7,933
lung cancer 26 | 4,466
lung adenocarcinoma 24 | 2,713
primitive neuroectodermal tumor 24 | 3,031
oligodendroglioma 23 | 2,849
Atrial Fibrillation 22 | 110
atypical teratoid / rhabdoid tumor 22 | 4,369
Breast cancer 21 | 3,094
diabetes mellitus 20 | 1,663
ependymoma 20 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
invasive ductal carcinoma 19 | 2,950
lung carcinoma 19 | 2,844
pediatric high grade glioma 19 | 2,712
pilocytic astrocytoma 19 | 3,086
Carcinoma 18 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
non-small cell lung cancer 18 | 2,798
pancreatic cancer 18 | 2,300
subependymal giant cell astrocytoma 18 | 2,287
astrocytic glioma 17 | 2,241
colon cancer 17 | 1,475
Heart disease 16 | 279
atypical teratoid/rhabdoid tumor 16 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,795
Cancer 15 | 2,346
Epilepsy 15 | 346
Pick disease 15 | 1,893
malignant mesothelioma 15 | 3,162
Long QT syndrome 14 | 52
adult high grade glioma 14 | 2,148
pituitary cancer 14 | 1,972
acute quadriplegic myopathy 13 | 1,157
ductal carcinoma in situ 13 | 1,745
group 3 medulloblastoma 13 | 2,254
group 4 medulloblastoma 13 | 1,875
Chronic heart failure 11 | 46
Hypertension 11 | 287
active Crohn's disease 11 | 918
astrocytoma 11 | 1,493
interstitial cystitis 11 | 2,299
fibroadenoma 10 | 557
posterior fossa group B ependymoma 10 | 1,530
Congestive heart failure 9 | 30
Prostatic Neoplasms 9 | 471
adrenocortical carcinoma 9 | 1,427
cystic fibrosis 9 | 1,665
posterior fossa group A ependymoma 9 | 1,511
primary pancreatic ductal adenocarcinoma 9 | 1,271
ulcerative colitis 9 | 2,087
Cardiomyopathy 8 | 110
Duchenne muscular dystrophy 8 | 602
Multiple myeloma 8 | 1,327
Parkinson's disease 8 | 364
Poisoning by digitalis glycoside 8 | 8
Schizophrenia 8 | 501
medulloblastoma 8 | 1,524
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,557
Brugada syndrome 7 | 26
Cardiomyopathies 7 | 90
Cerebrovascular disease 7 | 231
Congenital long QT syndrome 7 | 8
Coronary artery disease 7 | 240
Dilated cardiomyopathy 7 | 50
Heart conduction disease 7 | 65
Hypertensive disease 7 | 193
Hypertensive disorder 7 | 58
Obesity 7 | 616
Romano-Ward Syndrome 7 | 12
Short QT syndrome 7 | 12
breast carcinoma 7 | 1,614
pancreatic carcinoma 7 | 567
Atopic dermatitis 6 | 944
Cardiomyopathy, Dilated 6 | 47
Familial atrial fibrillation 6 | 16
Hypertrophic Cardiomyopathy 6 | 56
Myocardial Ischemia 6 | 169
Timothy syndrome 6 | 12
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
juvenile dermatomyositis 6 | 1,189
non primary Sjogren syndrome sicca 6 | 840
Brugada Syndrome (disorder) 5 | 15
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
Down syndrome 5 | 548
Endometriosis 5 | 535
Liver carcinoma 5 | 217
Liver disease 5 | 219
Multiple Sclerosis 5 | 498
Rheumatoid Arthritis 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
dermatomyositis 5 | 933
gastric cancer 5 | 430
gastric carcinoma 5 | 832
non-small cell lung carcinoma 5 | 413

Tissue

Digestive Tract 79 | 18,473
Liver and Pancreas 79 | 18,136
Urinary Tract 79 | 18,444
Blood and immune system 78 | 17,995
Female tissues 78 | 18,647
Skin and soft tissues 78 | 18,115
Endocrine System 77 | 18,512
Male tissues 77 | 17,969
Nervous System 77 | 18,561
Cardiovascular System 76 | 17,958
Respiratory system 76 | 17,484

Target Family

Non-IDG 24 | 11,971
Ion Channel 23 | 341
Enzyme 16 | 4,146
Transporter 11 | 473
GPCR 3 | 406
Kinase 2 | 634

PathwayCommons: smpdb Pathway

Phenytoin (Antiarrhythmic) Act... 79 | 79
Lidocaine (Antiarrhythmic) Act... 61 | 61
Carvedilol Action Pathway 60 | 60
Labetalol Action Pathway 60 | 60
Muscle/Heart Contraction 60 | 60
Acebutolol Action Pathway 59 | 59
Alprenolol Action Pathway 59 | 59
Amiodarone Action Pathway 59 | 59
Amlodipine Action Pathway 59 | 59
Arbutamine Action Pathway 59 | 59
Atenolol Action Pathway 59 | 59
Betaxolol Action Pathway 59 | 59
Bevantolol Action Pathway 59 | 59
Bisoprolol Action Pathway 59 | 59
Bopindolol Action Pathway 59 | 59
Bupranolol Action Pathway 59 | 59
Carteolol Action Pathway 59 | 59
Diltiazem Action Pathway 59 | 59
Disopyramide Action Pathway 59 | 59
Dobutamine Action Pathway 59 | 59
Epinephrine Action Pathway 59 | 59
Esmolol Action Pathway 59 | 59
Felodipine Action Pathway 59 | 59
Flecainide Action Pathway 59 | 59
Fosphenytoin (Antiarrhythmic) ... 59 | 59
Ibutilide Action Pathway 59 | 59
Isoprenaline Action Pathway 59 | 59
Isradipine Action Pathway 59 | 59
Levobunolol Action Pathway 59 | 59
Metipranolol Action Pathway 59 | 59
Metoprolol Action Pathway 59 | 59
Mexiletine Action Pathway 59 | 59
Nadolol Action Pathway 59 | 59
Nebivolol Action Pathway 59 | 59
Nifedipine Action Pathway 59 | 59
Nimodipine Action Pathway 59 | 59
Nisoldipine Action Pathway 59 | 59
Nitrendipine Action Pathway 59 | 59
Oxprenolol Action Pathway 59 | 59
Penbutolol Action Pathway 59 | 59
Pindolol Action Pathway 59 | 59
Practolol Action Pathway 59 | 59
Procainamide (Antiarrhythmic) ... 59 | 59
Propranolol Action Pathway 59 | 59
Quinidine Action Pathway 59 | 59
Sotalol Action Pathway 59 | 59
Timolol Action Pathway 59 | 59
Tocainide Action Pathway 59 | 59
Verapamil Action Pathway 59 | 59
Azathioprine Action Pathway 47 | 47
Ibuprofen Action Pathway 47 | 47
Mercaptopurine Action Pathway 47 | 47
Thioguanine Action Pathway 47 | 47
Warburg Effect 45 | 45
Intracellular Signalling Throu... 38 | 38
AICA-Ribosiduria 37 | 37
Adenine phosphoribosyltransfer... 37 | 37
Adenosine Deaminase Deficiency 37 | 37
Adenylosuccinate Lyase Deficie... 37 | 37
Gout or Kelley-Seegmiller Synd... 37 | 37
Intracellular Signalling Throu... 37 | 37
Lesch-Nyhan Syndrome (LNS) 37 | 37
Mitochondrial DNA depletion sy... 37 | 37
Molybdenum Cofactor Deficiency 37 | 37
Myoadenylate deaminase deficie... 37 | 37
Purine Metabolism 37 | 37
Purine Nucleoside Phosphorylas... 37 | 37
Xanthine Dehydrogenase Deficie... 37 | 37
Xanthinuria type I 37 | 37
Xanthinuria type II 37 | 37
Fc Epsilon Receptor I Signalin... 36 | 36
Morphine Action Pathway 35 | 35
Retinol Metabolism 35 | 35
Vitamin A Deficiency 35 | 35
Celecoxib Action Pathway 34 | 34
Eplerenone Action Pathway 33 | 33
Spironolactone Action Pathway 33 | 33
Amiloride Action Pathway 32 | 32
Bendroflumethiazide Action Pat... 32 | 32
Blue diaper syndrome 32 | 32
Bumetanide Action Pathway 32 | 32
Chlorothiazide Action Pathway 32 | 32
Chlorthalidone Action Pathway 32 | 32
Cyclothiazide Action Pathway 32 | 32
Cystinuria 32 | 32
Ethacrynic Acid Action Pathway 32 | 32
Furosemide Action Pathway 32 | 32
Glucose Transporter Defect (SG... 32 | 32
Hartnup Disorder 32 | 32
Hydrochlorothiazide Action Pat... 32 | 32
Hydroflumethiazide Action Path... 32 | 32
Iminoglycinuria 32 | 32
Indapamide Action Pathway 32 | 32
Kidney Function 32 | 32
Lysinuric Protein Intolerance 32 | 32
Lysinuric protein intolerance ... 32 | 32
Methyclothiazide Action Pathwa... 32 | 32
Metolazone Action Pathway 32 | 32
Polythiazide Action Pathway 32 | 32
Quinethazone Action Pathway 32 | 32

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peptidyl-prolyl cis-trans isomerase B PPIB Tchem Enzyme -2.21802 177.2 242
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.06431 1230.1 502
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.63112 407.4 169
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -1.96950 86.9 104
Troponin C, skeletal muscle TNNC2 Tchem Non-IDG -0.83474 6.42 84
ATP-binding cassette sub-family C member 8 ABCC8 Tclin Transporter -2.87986 827.3 168
Disks large homolog 1 DLG1 Tbio Non-IDG -2.17402 165.0 183
Inward rectifier potassium channel 4 KCNJ4 Tchem Ion Channel -1.87814 80.2 193
Calmodulin CALM3 Tclin Non-IDG -3.77570 5075.9 259
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.82576 681.4 264