Development Level

Tbio 1,313 | 10,625
Tdark 514 | 7,003
Tchem 235 | 1,890
Tclin 86 | 602

Collection

Eligible Ion Channel Proteins 17 | 117
Eligible Kinase Proteins 15 | 134
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 56 | 633
preweaning lethality, incomple... 45 | 260
abnormal behavior 40 | 226
decreased lean body mass 26 | 195
decreased bone mineral content 24 | 157
decreased body weight 23 | 174
decreased total body fat amoun... 23 | 186
hyperactivity 23 | 108
abnormal bone structure 22 | 131
decreased grip strength 22 | 123
increased or absent threshold ... 21 | 128
decreased body length 19 | 108
decreased bone mineral density 17 | 126
hypoactivity 17 | 89
increased circulating alkaline... 17 | 119
embryonic lethality prior to t... 15 | 187
increased bone mineral content 15 | 92
abnormal retina morphology 14 | 100
enlarged heart 14 | 111
decreased circulating choleste... 13 | 85
abnormal gait 12 | 51
decreased circulating HDL chol... 12 | 77
decreased circulating glucose ... 12 | 121
decreased prepulse inhibition 12 | 52
increased lean body mass 12 | 107
short tibia 12 | 82
decreased circulating insulin ... 11 | 75
decreased circulating triglyce... 11 | 83
decreased leukocyte cell numbe... 11 | 54
increased mean corpuscular hem... 11 | 93
limb grasping 11 | 35
decreased fasted circulating g... 10 | 49
decreased startle reflex 10 | 48
embryonic lethality prior to o... 10 | 148
increased circulating HDL chol... 10 | 63
male infertility 10 | 62
abnormal lens morphology 9 | 73
abnormal sleep behavior 9 | 63
decreased circulating serum al... 9 | 79
increased grip strength 9 | 83
increased mean corpuscular vol... 9 | 91
abnormal bone mineralization 8 | 55
abnormal coat/hair pigmentatio... 8 | 54
abnormal retinal pigmentation 8 | 61
abnormal seminal vesicle morph... 8 | 47
decreased circulating alanine ... 8 | 53
improved glucose tolerance 8 | 56
increased fasted circulating g... 8 | 68
prenatal lethality prior to he... 8 | 64
tremors 8 | 34
abnormal embryo size 7 | 112
abnormal eye morphology 7 | 38
abnormal heart morphology 7 | 51
absent pinna reflex 7 | 21
decreased caudal vertebrae num... 7 | 49
decreased circulating alkaline... 7 | 41
decreased circulating amylase ... 7 | 24
decreased circulating total pr... 7 | 41
decreased lumbar vertebrae num... 7 | 62
decreased rib number 7 | 59
impaired glucose tolerance 7 | 52
increased circulating choleste... 7 | 53
increased erythrocyte cell num... 7 | 26
increased startle reflex 7 | 38
abnormal kidney morphology 6 | 30
cataract 6 | 26
decreased circulating calcium ... 6 | 33
decreased heart weight 6 | 44
decreased hemoglobin content 6 | 53
female infertility 6 | 34
increased circulating calcium ... 6 | 32
increased circulating iron lev... 6 | 25
increased circulating sodium l... 6 | 71
thrombocytopenia 6 | 46
abnormal coat appearance 5 | 25
abnormal cranium morphology 5 | 32
abnormal epididymis morphology 5 | 31
abnormal iris morphology 5 | 12
abnormal locomotor activation 5 | 26
absent startle reflex 5 | 15
decreased circulating LDL chol... 5 | 37
decreased circulating aspartat... 5 | 27
decreased circulating glycerol... 5 | 19
decreased eosinophil cell numb... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased mean corpuscular vol... 5 | 50
enlarged lymph nodes 5 | 27
hydrops fetalis 5 | 22
increased CD4-positive, CD25-p... 5 | 18
increased bone mineral density 5 | 52
increased circulating phosphat... 5 | 24
increased circulating triglyce... 5 | 24
increased exploration in new e... 5 | 56
increased hematocrit 5 | 36
increased hemoglobin content 5 | 45
increased prepulse inhibition 5 | 21
increased sacral vertebrae num... 5 | 62
increased total body fat amoun... 5 | 57
persistence of hyaloid vascula... 5 | 22
vertebral fusion 5 | 23

Disease

adult high grade glioma 2,148 | 2,148
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 2,120 | 18,647
Digestive Tract 2,119 | 18,473
Nervous System 2,117 | 18,561
Urinary Tract 2,114 | 18,444
Endocrine System 2,111 | 18,512
Liver and Pancreas 2,106 | 18,136
Blood and immune system 2,097 | 17,995
Cardiovascular System 2,096 | 17,958
Male tissues 2,096 | 17,969
Skin and soft tissues 2,095 | 18,115
Respiratory system 2,070 | 17,484

Target Family

Non-IDG 1,284 | 11,971
Enzyme 462 | 4,146
Transcription Factor 121 | 1,400
Kinase 82 | 634
Ion Channel 53 | 341
Transporter 53 | 473
GPCR 45 | 406
Epigenetic 23 | 242
oGPCR 11 | 421
Nuclear Receptor 9 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase MGAT3 Tchem Enzyme -1.22408 15.8 139
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
CUGBP Elav-like family member 4 CELF4 Tbio Non-IDG -1.46075 29.8 40
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Killer cell lectin-like receptor subfamily B member 1 KLRB1 Tbio Non-IDG -2.39953 313.9 488
Zinc-alpha-2-glycoprotein AZGP1 Tbio Non-IDG -2.14317 164.1 198
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64