Development Level

Tbio 8,081 | 10,625
Tdark 3,411 | 7,003
Tchem 1,397 | 1,890
Tclin 407 | 602

Collection

Kinase: IDG Consortium (Targets) 99 | 125
Ion Channel: IDG Consortium (Targets) 45 | 102
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Targets) 31 | 127
GPCR: IDG Consortium (Complete/Control) 13 | 26

IMPC Phenotype

preweaning lethality, complete... 570 | 633
preweaning lethality, incomple... 217 | 260
abnormal behavior 199 | 226
decreased lean body mass 171 | 195
embryonic lethality prior to t... 170 | 187
decreased total body fat amoun... 164 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 141 | 148
decreased bone mineral content 137 | 157
abnormal bone structure 106 | 131
decreased bone mineral density 106 | 126
increased circulating alkaline... 104 | 119
increased or absent threshold ... 102 | 128
abnormal embryo size 99 | 112
decreased circulating glucose ... 96 | 121
decreased body length 95 | 108
decreased grip strength 95 | 123
hyperactivity 93 | 108
increased lean body mass 93 | 107
abnormal retina morphology 87 | 100
increased mean corpuscular hem... 85 | 93
increased mean corpuscular vol... 82 | 91
increased bone mineral content 81 | 92
decreased circulating choleste... 79 | 85
enlarged heart 78 | 111
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 71 | 79
hypoactivity 71 | 89
decreased circulating triglyce... 69 | 83
increased grip strength 66 | 83
abnormal lens morphology 59 | 73
increased fasted circulating g... 58 | 68
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 56 | 62
increased sacral vertebrae num... 55 | 62
increased circulating sodium l... 54 | 71
abnormal retinal pigmentation 53 | 61
decreased circulating insulin ... 53 | 75
abnormal sleep behavior 52 | 63
increased circulating HDL chol... 50 | 63
increased total body fat amoun... 50 | 57
decreased rib number 49 | 59
decreased leukocyte cell numbe... 48 | 54
increased circulating choleste... 48 | 53
decreased hemoglobin content 47 | 53
increased bone mineral density 47 | 52
abnormal bone mineralization 46 | 55
abnormal gait 46 | 51
decreased mean corpuscular vol... 46 | 50
male infertility 46 | 62
abnormal coat-hair pigmentatio... 45 | 54
impaired glucose tolerance 45 | 52
decreased prepulse inhibition 44 | 52
improved glucose tolerance 43 | 56
decreased circulating alanine ... 41 | 53
decreased caudal vertebrae num... 40 | 49
decreased erythrocyte cell num... 40 | 43
thrombocytopenia 40 | 46
abnormal behavioral response t... 39 | 52
decreased circulating total pr... 39 | 41
decreased fasted circulating g... 39 | 49
decreased startle reflex 38 | 48
decreased circulating LDL chol... 37 | 37
increased blood urea nitrogen ... 37 | 44
increased exploration in new e... 37 | 56
decreased heart weight 36 | 44
increased body weight 36 | 42
decreased neutrophil cell numb... 35 | 37
decreased eosinophil cell numb... 34 | 41
increased hemoglobin content 34 | 45
increased rib number 34 | 41
decreased circulating alkaline... 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
decreased circulating free fat... 32 | 39
abnormal eye morphology 31 | 38
increased circulating chloride... 31 | 43
abnormal seminal vesicle morph... 30 | 47
decreased circulating calcium ... 30 | 33
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased startle reflex 30 | 38
tremors 30 | 34
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased leukocyte cell numbe... 29 | 37
decreased T cell number 28 | 31
limb grasping 28 | 35
cardiovascular system phenotyp... 27 | 35
decreased circulating creatini... 27 | 31
increased circulating calcium ... 27 | 32
increased heart weight 27 | 37
small testis 27 | 37
increased circulating potassiu... 26 | 31
abnormal rib morphology 25 | 28
abnormal spleen morphology 25 | 36
decreased circulating aspartat... 25 | 27
decreased circulating chloride... 25 | 32
enlarged spleen 24 | 26

Disease

ovarian cancer 7,452 | 8,491
osteosarcoma 6,647 | 7,933
medulloblastoma, large-cell 5,165 | 6,234
glioblastoma 4,786 | 5,572
psoriasis 4,689 | 6,685
lung cancer 3,910 | 4,473
atypical teratoid / rhabdoid tumor 3,700 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,781 | 3,289
malignant mesothelioma 2,725 | 3,163
Breast cancer 2,622 | 3,098
invasive ductal carcinoma 2,576 | 2,950
pilocytic astrocytoma 2,568 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,559 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,538 | 2,988
primitive neuroectodermal tumor 2,508 | 3,031
oligodendroglioma 2,421 | 2,849
lung carcinoma 2,368 | 2,844
non-small cell lung cancer 2,275 | 2,798
pediatric high grade glioma 2,269 | 2,712
ependymoma 2,184 | 2,514
lung adenocarcinoma 2,118 | 2,714
subependymal giant cell astrocytoma 2,048 | 2,287
astrocytic glioma 1,930 | 2,241
group 3 medulloblastoma 1,887 | 2,254
pancreatic cancer 1,875 | 2,300
interstitial cystitis 1,769 | 2,299
Pick disease 1,757 | 1,893
adult high grade glioma 1,753 | 2,148
Cancer 1,741 | 2,346
ulcerative colitis 1,712 | 2,087
group 4 medulloblastoma 1,663 | 1,875
pituitary cancer 1,642 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,581 | 1,795
Carcinoma 1,542 | 2,147
ductal carcinoma in situ 1,446 | 1,745
cystic fibrosis 1,359 | 1,670
astrocytoma 1,356 | 1,493
breast carcinoma 1,354 | 1,614
tuberculosis 1,354 | 1,563
adrenocortical carcinoma 1,298 | 1,427
Multiple myeloma 1,293 | 1,327
medulloblastoma 1,267 | 1,524
sonic hedgehog group medulloblastoma 1,251 | 1,482
posterior fossa group A ependymoma 1,218 | 1,511
colon cancer 1,217 | 1,475
posterior fossa group B ependymoma 1,211 | 1,530
primary pancreatic ductal adenocarcinoma 1,160 | 1,271
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,107 | 1,663
acute quadriplegic myopathy 1,087 | 1,157
Rheumatoid Arthritis 980 | 1,170
dermatomyositis 898 | 966
atypical teratoid/rhabdoid tumor 884 | 1,095
spina bifida 853 | 1,064
cutaneous lupus erythematosus 851 | 1,056
nasopharyngeal carcinoma 746 | 1,056
gastric carcinoma 743 | 832
Waldenstrons macroglobulinemia 732 | 764
active Crohn's disease 723 | 918
acute myeloid leukemia 723 | 785
non primary Sjogren syndrome sicca 678 | 840
Atopic dermatitis 673 | 944
primary Sjogren syndrome 670 | 788
aldosterone-producing adenoma 653 | 664
tuberculosis and treatment for 6 months 648 | 686
progressive supranuclear palsy 621 | 674
esophageal adenocarcinoma 573 | 737
Duchenne muscular dystrophy 554 | 602
Alzheimer's disease 536 | 644
hepatocellular carcinoma 503 | 550
pancreatic carcinoma 493 | 567
Intellectual disability 490 | 573
Down syndrome 481 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
fibroadenoma 460 | 557
Obesity 457 | 616
IGA Glomerulonephritis 391 | 454
Prostatic Neoplasms 391 | 471
Amyotrophic Lateral Sclerosis 388 | 432
chronic rhinosinusitis 388 | 512
gastric cancer 388 | 436
Endometriosis 384 | 535
mucosa-associated lymphoid tissue lymphoma 378 | 480
Schizophrenia 360 | 503
active ulcerative colitis 357 | 477
Neurodegenerative disease 341 | 383
Mammary Neoplasms 331 | 410
Multiple Sclerosis 327 | 498
inflammatory breast cancer 318 | 404
hereditary spastic paraplegia 304 | 313
sarcoidosis 298 | 368
glioblastoma multiforme 294 | 347
tuberculosis and treatment for 3 months 284 | 327
Parkinson's disease 281 | 364
non-small cell lung carcinoma 271 | 413
Polycystic Ovary Syndrome 269 | 334
Kidney disease 256 | 397
interstitial lung disease 253 | 292
urothelial carcinoma 252 | 318
Epilepsy 249 | 346

Tissue

Endocrine System 13,296 | 18,511
Digestive Tract 13,293 | 18,472
Female tissues 13,293 | 18,646
Nervous System 13,292 | 18,560
Liver and Pancreas 13,288 | 18,135
Urinary Tract 13,288 | 18,443
Skin and soft tissues 13,287 | 18,114
Male tissues 13,278 | 17,968
Cardiovascular System 13,275 | 17,957
Blood and immune system 13,271 | 17,994
Respiratory system 13,261 | 17,483

Target Family

Non-IDG 7,653 | 11,969
Enzyme 3,245 | 4,146
Transcription Factor 967 | 1,400
Kinase 529 | 634
Transporter 304 | 473
Epigenetic 215 | 242
Ion Channel 164 | 341
GPCR 150 | 408
Nuclear Receptor 39 | 48
TF/Epigenetic 30 | 38

HPA RNA Tissue

adrenal gland 13,296 | 13,296
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Huntingtin HTT Tchem Non-IDG -3.32908 2140.8 521
Splicing regulatory glutamine/lysine-rich protein 1 SREK1 Tdark Non-IDG -0.37946 3.77 39
Protein Mpv17 MPV17 Tbio Non-IDG -1.63162 40.5 114
T-cell surface protein tactile CD96 Tbio Non-IDG -2.03517 108.7 142
Sorting nexin-32 SNX32 Tdark Non-IDG 0.60 0.07 75
E-selectin SELE Tchem Non-IDG -3.43650 2598.8 820
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.7 122
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135