Development Level

Tbio 9,948 | 11,445
Tdark 4,027 | 6,588
Tchem 1,382 | 1,598
Tclin 496 | 613

Collection

RFA-RM-18-021 258 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 82 | 99
GPCR: IDG Consortium (Targets) 68 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 15 | 25

IMPC Phenotype

preweaning lethality, complete... 946 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 275 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 174 | 210
abnormal bone structure 169 | 187
decreased vertical activity 167 | 208
increased lean body mass 158 | 172
decreased body weight 156 | 161
hyperactivity 139 | 148
abnormal heart morphology 137 | 162
decreased bone mineral content 133 | 151
hypoactivity 123 | 132
decreased lean body mass 120 | 135
increased total body fat amoun... 120 | 134
decreased bone mineral density 113 | 126
increased circulating alkaline... 111 | 122
decreased circulating glucose ... 109 | 126
increased startle reflex 107 | 112
male infertility 104 | 123
increased bone mineral content 102 | 108
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
decreased body length 94 | 101
abnormal seminal vesicle morph... 93 | 114
increased or absent threshold ... 90 | 101
short tibia 89 | 97
increased mean corpuscular vol... 87 | 92
increased mean corpuscular hem... 86 | 96
decreased circulating choleste... 84 | 93
cataract 82 | 92
prenatal lethality prior to he... 82 | 87
decreased circulating serum al... 77 | 82
decreased prepulse inhibition 76 | 82
abnormal lens morphology 73 | 81
decreased circulating triglyce... 72 | 79
decreased lymphocyte cell numb... 72 | 83
decreased mean corpuscular vol... 71 | 79
increased bone mineral density 71 | 72
decreased startle reflex 69 | 75
impaired glucose tolerance 69 | 75
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased circulating HDL chol... 67 | 80
abnormal retina morphology 66 | 71
decreased leukocyte cell numbe... 65 | 73
decreased circulating insulin ... 64 | 76
abnormal eye morphology 63 | 68
abnormal gait 63 | 69
small superior vagus ganglion 63 | 74
decreased circulating HDL chol... 62 | 68
decreased hemoglobin content 61 | 68
abnormal sleep behavior 60 | 70
increased circulating sodium l... 60 | 71
abnormal behavioral response t... 59 | 66
edema 58 | 59
abnormal coat-hair pigmentatio... 57 | 64
abnormal kidney morphology 57 | 65
decreased erythrocyte cell num... 56 | 62
decreased fasted circulating g... 56 | 65
increased heart weight 56 | 62
increased monocyte cell number 56 | 63
increased circulating choleste... 55 | 66
small testis 54 | 58
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
abnormal spleen morphology 49 | 55
female infertility 49 | 60
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
decreased mean corpuscular hem... 45 | 50
decreased circulating alanine ... 44 | 47
hydrometra 44 | 53
decreased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
abnormal skin morphology 41 | 50
abnormal testis morphology 41 | 43
increased hemoglobin content 40 | 45
increased neutrophil cell numb... 40 | 46
increased hematocrit 39 | 46
increased mean platelet volume 39 | 45
limb grasping 39 | 41
decreased neutrophil cell numb... 38 | 42
increased circulating triglyce... 38 | 42
abnormal bone mineralization 37 | 38
decreased red blood cell distr... 37 | 41
enlarged spleen 37 | 41
increased grip strength 37 | 41
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased circulating chloride... 36 | 41
tremors 36 | 39
abnormal cranium morphology 34 | 36
pallor 34 | 34

Disease

Carcinoma 9,680 | 11,493
ovarian cancer 7,959 | 8,520
osteosarcoma 7,232 | 7,950
medulloblastoma, large-cell 5,733 | 6,241
psoriasis 5,549 | 6,694
glioblastoma 5,367 | 5,792
atypical teratoid / rhabdoid tumor 4,781 | 5,112
ependymoma 4,312 | 4,679
lung cancer 4,298 | 4,740
group 3 medulloblastoma 3,829 | 4,104
adult high grade glioma 3,421 | 3,801
Breast cancer 3,280 | 3,578
malignant mesothelioma 3,043 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,008 | 3,291
primitive neuroectodermal tumor 2,843 | 3,035
Astrocytoma, Pilocytic 2,776 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,714 | 2,989
invasive ductal carcinoma 2,685 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,682 | 2,955
oligodendroglioma 2,649 | 2,850
non-small cell lung cancer 2,547 | 2,890
astrocytic glioma 2,421 | 2,597
lung carcinoma 2,421 | 2,843
lung adenocarcinoma 2,362 | 2,716
Kidney cancer 2,280 | 2,613
Cancer 2,172 | 2,499
pancreatic cancer 2,150 | 2,398
subependymal giant cell astrocytoma 2,132 | 2,287
interstitial cystitis 1,940 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,829 | 1,962
tuberculosis 1,803 | 2,010
Pick disease 1,792 | 1,894
pituitary cancer 1,784 | 1,972
group 4 medulloblastoma 1,744 | 1,855
ductal carcinoma in situ 1,591 | 1,745
ulcerative colitis 1,555 | 1,819
cystic fibrosis 1,499 | 1,696
breast carcinoma 1,478 | 1,638
diabetes mellitus 1,352 | 1,728
colon cancer 1,308 | 1,478
adrenocortical carcinoma 1,299 | 1,428
Multiple myeloma 1,298 | 1,332
Autosomal recessive predisposition 1,275 | 1,442
juvenile dermatomyositis 1,117 | 1,187
acute quadriplegic myopathy 1,108 | 1,158
astrocytoma 1,076 | 1,146
Rheumatoid arthritis 1,073 | 1,191
primary pancreatic ductal adenocarcinoma 1,039 | 1,109
spina bifida 1,001 | 1,074
pediatric high grade glioma 995 | 1,064
Schizophrenia 972 | 1,160
Intellectual disability 960 | 1,016
dermatomyositis 934 | 966
nasopharyngeal carcinoma 903 | 1,058
cutaneous lupus erythematosus 850 | 1,057
active Crohn's disease 807 | 922
non primary Sjogren syndrome sicca 793 | 891
Atopic dermatitis 788 | 952
acute myeloid leukemia 748 | 783
gastric carcinoma 746 | 807
Waldenstrons macroglobulinemia 732 | 765
Epilepsy 722 | 792
medulloblastoma 672 | 720
Liver Cirrhosis, Experimental 663 | 769
active ulcerative colitis 657 | 764
progressive supranuclear palsy 641 | 676
esophageal adenocarcinoma 629 | 737
aldosterone-producing adenoma 625 | 665
primary Sjogren syndrome 619 | 735
Dull intelligence 610 | 645
Low intelligence 610 | 645
Mental Retardation 610 | 645
Mental deficiency 610 | 645
Poor school performance 610 | 645
Cognitive delay 583 | 608
Global developmental delay 583 | 608
Mental and motor retardation 583 | 608
Alzheimer's disease 576 | 658
Obesity 572 | 678
Bipolar Disorder 548 | 666
Duchenne muscular dystrophy 547 | 601
Muscle hypotonia 547 | 571
Melanoma 546 | 711
Seizures 545 | 596
Liver cancer 518 | 604
pancreatic carcinoma 510 | 562
hepatocellular carcinoma 500 | 547
Short stature 497 | 531
fibroadenoma 495 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 484 | 510
Endometriosis 481 | 540
Down syndrome 465 | 499
Prostatic Neoplasms 447 | 495
chronic rhinosinusitis 441 | 512
sonic hedgehog group medulloblastoma 433 | 467
Multiple Sclerosis 430 | 540
posterior fossa group A ependymoma 426 | 468
Amyotrophic lateral sclerosis 420 | 451
gastric cancer 416 | 459
Breast Neoplasms 402 | 445

Tissue

Endocrine System 15,573 | 18,159
Digestive Tract 15,345 | 17,369
Female tissues 15,344 | 17,400
Skin and soft tissues 15,307 | 17,230
Male tissues 15,226 | 17,142
Nervous System 15,140 | 16,725
Blood and immune system 15,123 | 16,909
Liver and Pancreas 15,045 | 16,750
Urinary Tract 15,025 | 16,678
Respiratory system 14,878 | 16,393
Cardiovascular System 14,154 | 15,192

Target Family

Non-IDG 9,136 | 12,091
Enzyme 3,597 | 4,145
Transcription Factor 1,285 | 1,400
Kinase 597 | 634
Transporter 390 | 473
Ion Channel 277 | 344
GPCR 252 | 408
Epigenetic 229 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 34 | 38
oGPCR 11 | 421

HCA RNA Cell Line

HEK 293 15,853 | 15,853
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Spermidine/spermine N(1)-acetyltransferase-like protein 1 SATL1 Tdark Enzyme 0.00000 56
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63