Development Level

Tbio 10,490 | 11,445
Tdark 4,249 | 6,588
Tchem 1,463 | 1,598
Tclin 524 | 613

Collection

RFA-RM-18-021 269 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 82 | 99
GPCR: IDG Consortium (Targets) 76 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 957 | 979
preweaning lethality, incomple... 478 | 499
abnormal behavior 282 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 196 | 207
enlarged heart 181 | 210
decreased vertical activity 176 | 208
abnormal bone structure 175 | 187
increased lean body mass 164 | 172
decreased body weight 154 | 161
abnormal heart morphology 142 | 162
decreased bone mineral content 142 | 151
hyperactivity 137 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 126 | 134
decreased circulating glucose ... 120 | 126
decreased bone mineral density 119 | 126
hypoactivity 119 | 132
male infertility 115 | 123
increased circulating alkaline... 113 | 122
increased startle reflex 109 | 112
decreased grip strength 105 | 116
increased bone mineral content 104 | 108
embryonic growth retardation 102 | 106
decreased body length 96 | 101
abnormal seminal vesicle morph... 95 | 114
increased or absent threshold ... 93 | 101
increased mean corpuscular hem... 90 | 96
short tibia 90 | 97
increased mean corpuscular vol... 88 | 92
decreased circulating choleste... 87 | 93
cataract 86 | 92
prenatal lethality prior to he... 85 | 87
abnormal lens morphology 78 | 81
decreased lymphocyte cell numb... 75 | 83
decreased circulating triglyce... 74 | 79
decreased prepulse inhibition 74 | 82
decreased circulating serum al... 73 | 82
decreased mean corpuscular vol... 73 | 79
increased circulating HDL chol... 73 | 80
improved glucose tolerance 71 | 79
increased fasted circulating g... 71 | 76
decreased circulating insulin ... 70 | 76
increased bone mineral density 70 | 72
decreased startle reflex 69 | 75
impaired glucose tolerance 69 | 75
decreased leukocyte cell numbe... 68 | 73
increased circulating sodium l... 68 | 71
abnormal retina morphology 67 | 71
small superior vagus ganglion 67 | 74
abnormal sleep behavior 66 | 70
abnormal eye morphology 65 | 68
decreased circulating HDL chol... 65 | 68
decreased hemoglobin content 64 | 68
abnormal gait 62 | 69
increased circulating choleste... 62 | 66
abnormal coat-hair pigmentatio... 61 | 64
decreased fasted circulating g... 61 | 65
decreased erythrocyte cell num... 60 | 62
increased heart weight 59 | 62
increased monocyte cell number 58 | 63
abnormal behavioral response t... 57 | 66
edema 56 | 59
abnormal kidney morphology 55 | 65
thrombocytopenia 54 | 56
female infertility 53 | 60
small testis 53 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 52 | 53
decreased blood urea nitrogen ... 48 | 51
decreased mean corpuscular hem... 48 | 50
hydrometra 48 | 53
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
decreased circulating total pr... 46 | 49
increased blood urea nitrogen ... 46 | 48
abnormal skin morphology 45 | 50
decreased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 43 | 46
increased circulating triglyce... 42 | 42
decreased neutrophil cell numb... 41 | 42
increased mean platelet volume 41 | 45
enlarged spleen 40 | 41
increased leukocyte cell numbe... 40 | 47
increased circulating chloride... 39 | 41
increased grip strength 39 | 41
increased hematocrit 39 | 46
increased hemoglobin content 39 | 45
abnormal bone mineralization 38 | 38
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
abnormal epididymis morphology 37 | 42
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
limb grasping 37 | 41
tremors 37 | 39
abnormal cranium morphology 36 | 36

Disease

Carcinoma 10,137 | 11,493
ovarian cancer 8,178 | 8,520
osteosarcoma 7,487 | 7,950
psoriasis 5,899 | 6,694
medulloblastoma, large-cell 5,863 | 6,241
glioblastoma 5,505 | 5,792
atypical teratoid / rhabdoid tumor 4,851 | 5,112
lung cancer 4,466 | 4,740
ependymoma 4,392 | 4,679
group 3 medulloblastoma 3,885 | 4,104
adult high grade glioma 3,535 | 3,801
Breast cancer 3,405 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,173 | 3,291
malignant mesothelioma 3,111 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,880 | 2,989
Astrocytoma, Pilocytic 2,879 | 3,081
primitive neuroectodermal tumor 2,870 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,837 | 2,955
invasive ductal carcinoma 2,823 | 2,951
non-small cell lung cancer 2,748 | 2,890
oligodendroglioma 2,682 | 2,850
lung carcinoma 2,596 | 2,843
lung adenocarcinoma 2,532 | 2,716
astrocytic glioma 2,445 | 2,597
Kidney cancer 2,358 | 2,613
Cancer 2,307 | 2,499
pancreatic cancer 2,284 | 2,398
subependymal giant cell astrocytoma 2,190 | 2,287
interstitial cystitis 2,140 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,900 | 1,962
tuberculosis 1,894 | 2,010
pituitary cancer 1,839 | 1,972
Pick disease 1,810 | 1,894
group 4 medulloblastoma 1,769 | 1,855
ulcerative colitis 1,695 | 1,819
ductal carcinoma in situ 1,664 | 1,745
cystic fibrosis 1,593 | 1,696
breast carcinoma 1,564 | 1,638
diabetes mellitus 1,466 | 1,728
colon cancer 1,391 | 1,478
adrenocortical carcinoma 1,379 | 1,428
Autosomal recessive predisposition 1,337 | 1,442
Multiple myeloma 1,312 | 1,332
juvenile dermatomyositis 1,159 | 1,187
Rheumatoid arthritis 1,132 | 1,191
acute quadriplegic myopathy 1,131 | 1,158
astrocytoma 1,121 | 1,146
primary pancreatic ductal adenocarcinoma 1,083 | 1,109
spina bifida 1,038 | 1,074
pediatric high grade glioma 1,021 | 1,064
Schizophrenia 1,017 | 1,160
Intellectual disability 972 | 1,016
nasopharyngeal carcinoma 970 | 1,058
cutaneous lupus erythematosus 963 | 1,057
dermatomyositis 954 | 966
active Crohn's disease 880 | 922
Atopic dermatitis 850 | 952
non primary Sjogren syndrome sicca 814 | 891
gastric carcinoma 771 | 807
acute myeloid leukemia 764 | 783
Waldenstrons macroglobulinemia 752 | 765
Epilepsy 734 | 792
Liver Cirrhosis, Experimental 724 | 769
active ulcerative colitis 719 | 764
esophageal adenocarcinoma 699 | 737
primary Sjogren syndrome 689 | 735
medulloblastoma 683 | 720
progressive supranuclear palsy 654 | 676
aldosterone-producing adenoma 649 | 665
Dull intelligence 619 | 645
Low intelligence 619 | 645
Mental Retardation 619 | 645
Mental deficiency 619 | 645
Poor school performance 619 | 645
Obesity 609 | 678
Alzheimer's disease 596 | 658
Melanoma 591 | 711
Cognitive delay 586 | 608
Global developmental delay 586 | 608
Mental and motor retardation 586 | 608
Duchenne muscular dystrophy 579 | 601
Bipolar Disorder 577 | 666
Seizures 560 | 596
Muscle hypotonia 551 | 571
pancreatic carcinoma 541 | 562
fibroadenoma 535 | 559
Liver cancer 533 | 604
hepatocellular carcinoma 530 | 547
Short stature 505 | 531
Endometriosis 503 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 510
Down syndrome 478 | 499
Prostatic Neoplasms 473 | 495
chronic rhinosinusitis 471 | 512
Multiple Sclerosis 465 | 540
gastric cancer 446 | 459
sonic hedgehog group medulloblastoma 443 | 467
posterior fossa group A ependymoma 440 | 468
Amyotrophic lateral sclerosis 431 | 451
mucosa-associated lymphoid tissue lymphoma 426 | 484

Tissue

Endocrine System 16,409 | 18,159
Female tissues 16,100 | 17,400
Digestive Tract 16,082 | 17,369
Skin and soft tissues 15,998 | 17,230
Male tissues 15,973 | 17,142
Blood and immune system 15,811 | 16,909
Liver and Pancreas 15,726 | 16,750
Nervous System 15,718 | 16,725
Urinary Tract 15,669 | 16,678
Respiratory system 15,502 | 16,393
Cardiovascular System 14,569 | 15,192

Target Family

Non-IDG 9,750 | 12,091
Enzyme 3,764 | 4,145
Transcription Factor 1,278 | 1,400
Kinase 608 | 634
Transporter 416 | 473
GPCR 285 | 408
Ion Channel 276 | 344
Epigenetic 235 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 35 | 38
oGPCR 32 | 421

HCA RNA Cell Line

BEWO 16,726 | 16,726
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Spermidine/spermine N(1)-acetyltransferase-like protein 1 SATL1 Tdark Enzyme 0.00000 56
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28