Development Level

Tbio 246 | 11,445
Tdark 52 | 6,588
Tchem 46 | 1,598
Tclin 23 | 613

Collection

RFA-RM-18-021 6 | 328
Kinase: IDG Consortium (Target... 4 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 34 | 979
preweaning lethality, incomple... 21 | 499
embryonic lethality prior to t... 10 | 278
abnormal embryo size 9 | 220
decreased total body fat amoun... 7 | 207
decreased circulating glucose ... 6 | 126
decreased circulating triglyce... 6 | 79
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
abnormal seminal vesicle morph... 5 | 114
decreased circulating choleste... 5 | 93
enlarged heart 5 | 210
increased mean corpuscular vol... 5 | 92
prenatal lethality prior to he... 5 | 87
small testis 5 | 58
abnormal behavior 4 | 298
abnormal epididymis morphology 4 | 42
cataract 4 | 92
decreased erythrocyte cell num... 4 | 62
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
decreased mean corpuscular vol... 4 | 79
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
decreased body weight 3 | 161
decreased caudal vertebrae num... 3 | 53
decreased circulating free fat... 3 | 31
decreased circulating serum al... 3 | 82
decreased lymphocyte cell numb... 3 | 83
enlarged epididymis 3 | 31
hypoactivity 3 | 132
increased body length 3 | 32
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased erythrocyte cell num... 3 | 39
increased fasted circulating g... 3 | 76
increased monocyte cell number 3 | 63
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
thrombocytosis 3 | 27
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal pericardium morpholog... 2 | 26
abnormal skin appearance 2 | 3
abnormal snout morphology 2 | 23
abnormal spleen morphology 2 | 55
abnormal tooth morphology 2 | 24
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating unsatura... 2 | 2
decreased grip strength 2 | 116
decreased heart rate 2 | 18
decreased mean corpuscular hem... 2 | 50
decreased total retina thickne... 2 | 17
edema 2 | 59
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
pallor 2 | 34
prenatal lethality 2 | 28
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal craniofacial morpholo... 1 | 33
abnormal ear morphology 1 | 9
abnormal neural tube closure 1 | 46
abnormal retinal inner nuclear... 1 | 8
abnormal vocalization 1 | 21
convulsive seizures 1 | 13
decreased circulating bilirubi... 1 | 19
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fluid intake 1 | 3
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased red blood cell distr... 1 | 34
long tibia 1 | 25
thin ventricular wall 1 | 24

Disease

Carcinoma 278 | 11,493
ovarian cancer 206 | 8,520
osteosarcoma 193 | 7,950
glioblastoma 160 | 5,792
medulloblastoma, large-cell 157 | 6,241
psoriasis 155 | 6,694
atypical teratoid / rhabdoid tumor 138 | 5,112
ependymoma 122 | 4,679
lung cancer 121 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 113 | 2,955
Breast cancer 109 | 3,578
Astrocytoma, Pilocytic 103 | 3,081
Kidney cancer 103 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 103 | 2,989
adult high grade glioma 102 | 3,801
group 3 medulloblastoma 101 | 4,104
non-small cell lung cancer 101 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 99 | 3,291
malignant mesothelioma 98 | 3,232
lung adenocarcinoma 92 | 2,716
invasive ductal carcinoma 89 | 2,951
lung carcinoma 88 | 2,843
primitive neuroectodermal tumor 86 | 3,035
pancreatic cancer 81 | 2,398
Cancer 76 | 2,499
oligodendroglioma 76 | 2,850
astrocytic glioma 72 | 2,597
subependymal giant cell astrocytoma 70 | 2,287
cystic fibrosis 66 | 1,696
diabetes mellitus 63 | 1,728
interstitial cystitis 63 | 2,312
tuberculosis 63 | 2,010
ulcerative colitis 62 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,962
Pick disease 58 | 1,894
ductal carcinoma in situ 58 | 1,745
Cardiovascular system disease 57 | 246
Coronary artery disease 50 | 268
pituitary cancer 48 | 1,972
adrenocortical carcinoma 47 | 1,428
Autosomal recessive predisposition 45 | 1,442
group 4 medulloblastoma 45 | 1,855
astrocytoma 44 | 1,146
breast carcinoma 44 | 1,638
acute quadriplegic myopathy 43 | 1,158
Atherosclerosis 41 | 291
primary pancreatic ductal adenocarcinoma 41 | 1,109
colon cancer 39 | 1,478
Rheumatoid arthritis 38 | 1,191
juvenile dermatomyositis 38 | 1,187
Schizophrenia 36 | 1,160
gastric carcinoma 36 | 807
spina bifida 36 | 1,074
Obesity 33 | 678
pediatric high grade glioma 32 | 1,064
dermatomyositis 31 | 966
Melanoma 30 | 711
Multiple myeloma 30 | 1,332
Liver cancer 29 | 604
Prostatic Neoplasms 28 | 495
Alzheimer's disease 27 | 658
active Crohn's disease 27 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 510
Atopic dermatitis 26 | 952
Kidney disease 25 | 430
primary Sjogren syndrome 25 | 735
Duchenne muscular dystrophy 24 | 601
Cerebrovascular disease 23 | 238
Epilepsy 23 | 792
Hypertension 23 | 396
Lipid metabolism disorder 23 | 114
Type 2 diabetes mellitus 23 | 272
active ulcerative colitis 23 | 764
cutaneous lupus erythematosus 23 | 1,057
Liver Cirrhosis, Experimental 22 | 769
Waldenstrons macroglobulinemia 22 | 765
nasopharyngeal carcinoma 21 | 1,058
Intellectual disability 20 | 1,016
Myocardial Infarction 20 | 151
esophageal adenocarcinoma 20 | 737
Acquired metabolic disease 19 | 336
Hypertensive disease 19 | 292
Seizures 19 | 596
Skin cancer 19 | 469
Vascular disease 19 | 319
aldosterone-producing adenoma 19 | 665
pancreatic carcinoma 19 | 562
posterior fossa group A ependymoma 19 | 468
progressive supranuclear palsy 19 | 676
Bipolar Disorder 18 | 666
Essential Hypertension 18 | 94
head and neck cancer 18 | 271
interstitial lung disease 18 | 298
non primary Sjogren syndrome sicca 18 | 891
Heart disease 17 | 306
Crohn's disease 16 | 321
Depressive disorder 16 | 409
Glaucoma 16 | 239
fibroadenoma 16 | 559
hepatocellular carcinoma 16 | 547

Tissue

Endocrine System 359 | 18,159
Female tissues 356 | 17,400
Digestive Tract 354 | 17,369
Liver and Pancreas 354 | 16,750
Skin and soft tissues 351 | 17,230
Blood and immune system 350 | 16,909
Male tissues 349 | 17,142
Urinary Tract 348 | 16,678
Respiratory system 345 | 16,393
Nervous System 344 | 16,725
Cardiovascular System 329 | 15,192

Target Family

Non-IDG 204 | 12,091
Enzyme 81 | 4,145
Transcription Factor 28 | 1,400
Kinase 22 | 634
Transporter 11 | 473
Ion Channel 7 | 344
Epigenetic 6 | 242
GPCR 4 | 408
TF/Epigenetic 4 | 38

GWAS Trait

Coronary artery disease 367 | 367
Obesity-related traits 569 | 569
Schizophrenia 533 | 533
Breast cancer 492 | 492
Body mass index 379 | 379
Height 369 | 369
Blood protein levels 351 | 351
Post bronchodilator FEV1-FVC r... 308 | 308
Mean corpuscular volume 283 | 283
Platelet count 275 | 275
Intelligence (multi-trait anal... 267 | 267
Mean platelet volume 253 | 253
IgG glycosylation 250 | 250
Mean corpuscular hemoglobin 238 | 238
Inflammatory bowel disease 235 | 235
Plateletcrit 227 | 227
Crohn's disease 215 | 215
Type 2 diabetes 210 | 210
Red blood cell count 191 | 191
Monocyte count 183 | 183
Red cell distribution width 182 | 182
Eosinophil counts 180 | 180
Neuroticism 180 | 180
Platelet distribution width 174 | 174
Monocyte percentage of white c... 173 | 173
Post bronchodilator FEV1 173 | 173
Sum eosinophil basophil counts 173 | 173
White blood cell count 172 | 172
3-hydroxy-1-methylpropylmercap... 166 | 166
Eosinophil percentage of granu... 163 | 163
Eosinophil percentage of white... 163 | 163
Reticulocyte fraction of red c... 163 | 163
Ulcerative colitis 163 | 163
Granulocyte percentage of myel... 162 | 162
Itch intensity from mosquito b... 162 | 162
Systemic lupus erythematosus 159 | 159
High light scatter reticulocyt... 158 | 158
Lymphocyte counts 158 | 158
Reticulocyte count 158 | 158
Blood metabolite levels 157 | 157
Neutrophil count 154 | 154
High light scatter reticulocyt... 153 | 153
Neutrophil percentage of granu... 153 | 153
3-hydroxypropylmercapturic aci... 150 | 150
Tonsillectomy 149 | 149
Diastolic blood pressure 144 | 144
Sum basophil neutrophil counts 140 | 140
Autism spectrum disorder or sc... 134 | 134
Myeloid white cell count 133 | 133
Granulocyte count 132 | 132
Sum neutrophil eosinophil coun... 129 | 129
Colorectal cancer 126 | 126
Alzheimer disease and age of o... 124 | 124
Multiple sclerosis 124 | 124
Cholesterol, total 123 | 123
Night sleep phenotypes 123 | 123
Lung cancer 122 | 122
Lymphocyte percentage of white... 122 | 122
Menarche (age at onset) 122 | 122
Neutrophil percentage of white... 121 | 121
Rheumatoid arthritis 121 | 121
Systolic blood pressure 120 | 120
Immature fraction of reticuloc... 118 | 118
Diisocyanate-induced asthma 116 | 116
HDL cholesterol 116 | 116
Allergic disease (asthma, hay ... 115 | 115
Educational attainment (years ... 114 | 114
Hematocrit 113 | 113
Hemoglobin concentration 112 | 112
LDL cholesterol 110 | 110
QT interval 110 | 110
Waist circumference adjusted f... 110 | 110
Mosquito bite size 107 | 107
Asthma 106 | 106
Lobe attachment (rater-scored ... 103 | 103
Peripheral arterial disease (t... 101 | 101
Pulse pressure 97 | 97
Bipolar disorder 94 | 94
Major depressive disorder 94 | 94
Prostate cancer 92 | 92
Parkinson's disease 90 | 90
Hip circumference adjusted for... 89 | 89
Metabolite levels 87 | 87
Triglycerides 87 | 87
Colonoscopy-negative controls ... 85 | 85
Mean corpuscular hemoglobin co... 85 | 85
Itch intensity from mosquito b... 84 | 84
Bipolar disorder and schizophr... 83 | 83
Resting heart rate 82 | 82
Macrophage inflammatory protei... 81 | 81
Migraine 81 | 81
Waist-to-hip ratio adjusted fo... 81 | 81
PR interval in Tripanosoma cru... 80 | 80
Cognitive performance 79 | 79
Glomerular filtration rate (cr... 78 | 78
Late-onset Alzheimer's disease 78 | 78
Waist circumference adjusted f... 75 | 75
Tuberculosis 73 | 73
Type 1 diabetes 73 | 73
Morning vs. evening chronotype 72 | 72

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
Cadherin EGF LAG seven-pass G-type receptor 2 CELSR2 Tbio GPCR -1.22995 16.7 139
Histo-blood group ABO system transferase ABO Tbio Enzyme 0.00000 0
Arsenite methyltransferase AS3MT Tbio Enzyme -2.10657 132.7 88
Centrosomal protein of 120 kDa CEP120 Tbio Non-IDG -0.93215 7.32 49
R3H domain-containing protein 2 R3HDM2 Tdark Non-IDG -0.82119 4.93 39
Transmembrane protein 204 TMEM204 Tbio Non-IDG -0.59045 4.13 52
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.78912 62.9 93
Semaphorin-5A SEMA5A Tbio Non-IDG -1.82162 69.8 238
UHRF1-binding protein 1 UHRF1BP1 Tbio Non-IDG -1.30331 22.0 34