Development Level

Tbio 172 | 11,651
Tdark 36 | 6,593
Tchem 7 | 1,388
Tclin 7 | 612

IMPC Phenotype

preweaning lethality, incomple... 14 | 499
preweaning lethality, complete... 11 | 979
abnormal behavior 10 | 298
decreased bone mineral content 5 | 151
abnormal embryo size 4 | 220
decreased circulating total pr... 4 | 49
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
enlarged heart 4 | 210
hyperactivity 4 | 148
hypoactivity 4 | 132
abnormal heart morphology 3 | 162
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased hemoglobin content 3 | 68
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
increased mean corpuscular vol... 3 | 92
male infertility 3 | 123
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal vocalization 2 | 21
decreased basophil cell number 2 | 16
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
dilated heart left ventricle 2 | 11
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
female infertility 2 | 60
increased blood urea nitrogen ... 2 | 48
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
limb grasping 2 | 41
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal hair growth 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
absent spleen 1 | 3
corneal opacity 1 | 32
cystolithiasis 1 | 3
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased eosinophil cell numb... 1 | 24
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
thick skin 1 | 4
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

ovarian cancer 145 | 8,520
Carcinoma 136 | 11,493
osteosarcoma 107 | 7,950
glioblastoma 81 | 5,792
medulloblastoma, large-cell 81 | 6,241
psoriasis 79 | 6,694
lung cancer 72 | 4,740
atypical teratoid / rhabdoid tumor 68 | 5,112
Multiple myeloma 51 | 1,332
adult high grade glioma 50 | 3,801
ependymoma 49 | 4,679
Breast cancer 48 | 3,578
group 3 medulloblastoma 48 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
malignant mesothelioma 38 | 3,232
astrocytic glioma 37 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
primitive neuroectodermal tumor 35 | 3,035
oligodendroglioma 34 | 2,850
Astrocytoma, Pilocytic 33 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
subependymal giant cell astrocytoma 33 | 2,287
Cancer 32 | 2,499
Kidney cancer 32 | 2,613
group 4 medulloblastoma 31 | 1,855
tuberculosis 30 | 2,010
Pick disease 28 | 1,894
non-small cell lung cancer 28 | 2,890
pancreatic cancer 28 | 2,398
invasive ductal carcinoma 27 | 2,951
juvenile dermatomyositis 26 | 1,187
dermatomyositis 25 | 966
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
lung adenocarcinoma 20 | 2,716
pituitary cancer 20 | 1,972
ulcerative colitis 20 | 1,819
acute quadriplegic myopathy 18 | 1,158
spina bifida 18 | 1,074
Rheumatoid arthritis 17 | 1,191
lung carcinoma 17 | 2,843
HIV Infections 16 | 102
Waldenstrons macroglobulinemia 16 | 765
astrocytoma 16 | 1,146
non primary Sjogren syndrome sicca 15 | 891
breast carcinoma 14 | 1,638
cutaneous lupus erythematosus 14 | 1,057
acute myeloid leukemia 13 | 783
cystic fibrosis 13 | 1,696
primary Sjogren syndrome 13 | 735
adrenocortical carcinoma 12 | 1,428
diabetes mellitus 12 | 1,728
interstitial cystitis 12 | 2,312
primary pancreatic ductal adenocarcinoma 12 | 1,109
progressive supranuclear palsy 12 | 676
medulloblastoma 11 | 720
Intellectual disability 10 | 1,016
Parkinson's disease 10 | 392
ductal carcinoma in situ 10 | 1,745
esophageal adenocarcinoma 10 | 737
gastric carcinoma 10 | 807
pediatric high grade glioma 10 | 1,064
Alzheimer's disease 9 | 658
Amyotrophic lateral sclerosis 9 | 451
Autosomal recessive predisposition 9 | 1,442
colon cancer 9 | 1,478
tuberculosis and treatment for 6 months 9 | 409
Atopic dermatitis 8 | 952
Duchenne muscular dystrophy 8 | 601
active Crohn's disease 8 | 922
aldosterone-producing adenoma 8 | 665
Dull intelligence 7 | 645
Low intelligence 7 | 645
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
active ulcerative colitis 7 | 764
chronic rhinosinusitis 7 | 512
hepatocellular carcinoma 7 | 547
nasopharyngeal carcinoma 7 | 1,058
Epilepsy 6 | 792
Liver cancer 6 | 604
Neurodegenerative disease 6 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
gastric cancer 6 | 459
sarcoidosis 6 | 370
Bipolar Disorder 5 | 666
Breast Neoplasms 5 | 445
Endometrial cancer 5 | 311
Endometriosis 5 | 540
Hypertensive disease 5 | 292
Hypogonadism 5 | 173
Liver Cirrhosis, Experimental 5 | 769
Mammary Neoplasms 5 | 425
Mantle cell lymphoma 5 | 23
Multiple Sclerosis 5 | 540
Osteoporosis 5 | 363
Seizures 5 | 596
Systemic lupus erythematosus 5 | 194
sonic hedgehog group medulloblastoma 5 | 467

Tissue

Endocrine System 221 | 18,159
Female tissues 220 | 17,400
Nervous System 219 | 16,725
Digestive Tract 218 | 17,369
Male tissues 218 | 17,142
Blood and immune system 217 | 16,909
Urinary Tract 217 | 16,678
Liver and Pancreas 216 | 16,750
Respiratory system 216 | 16,393
Skin and soft tissues 216 | 17,230
Cardiovascular System 209 | 15,192

Target Family

Enzyme 117 | 4,145
Non-IDG 99 | 12,091
Epigenetic 3 | 242
Transcription Factor 2 | 1,400
Kinase 1 | 634

GO Process

protein polyubiquitination 222 | 222
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase TRIM69 TRIM69 Tbio Enzyme -0.52311 4.44 253
F-box/LRR-repeat protein 4 FBXL4 Tbio Non-IDG -1.13805 13.4 82
F-box/LRR-repeat protein 5 FBXL5 Tbio Non-IDG -1.25684 20.6 145
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
E3 ubiquitin-protein ligase RNF114 RNF114 Tbio Enzyme -1.03564 12.8 142
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.52486 353.9 144
E3 ubiquitin-protein ligase MARCH5 MARCH5 Tbio Epigenetic -1.47833 33.3 156
F-box only protein 9 FBXO9 Tbio Non-IDG -0.42429 2.33 122
F-box only protein 10 FBXO10 Tdark Non-IDG -0.62411 4.71 38
Leucyl-cystinyl aminopeptidase LNPEP Tchem Enzyme -2.57244 394.0 103