Development Level

Tclin 17 | 613
Tbio 3 | 11,445
Tchem 2 | 1,598

Collection

Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal pancreas morphology 1 | 13
abnormal spleen morphology 1 | 55
decreased body length 1 | 101
decreased circulating alkaline... 1 | 46
preweaning lethality, complete... 1 | 979
small heart 1 | 10
small liver 1 | 8

Disease

Carcinoma 19 | 11,493
Epilepsy 15 | 792
Kidney cancer 13 | 2,613
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
lung carcinoma 11 | 2,843
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 11 | 7,950
Atrial Fibrillation 10 | 124
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Lennox-Gastaut syndrome 10 | 34
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 27
adult high grade glioma 10 | 3,801
psoriasis 10 | 6,694
Astrocytoma, Pilocytic 9 | 3,081
Anesthesia for cesarean section 8 | 8
Bipolar disorder in remission 8 | 19
Major Nerve Block for Surgery 8 | 8
Regional Anesthesia for Labor Pain 8 | 9
Regional Anesthesia for Postoperative Pain 8 | 9
Regional Anesthesia for Surgery 8 | 9
Simple partial seizure 8 | 26
Tonic-clonic seizure 8 | 11
lung cancer 8 | 4,740
Administration of Local Anesthetic Nerve Block 7 | 14
Administration of Regional Anesthesia 7 | 7
Breast cancer 7 | 3,578
Local Anesthesia for Ophthalmologic Procedure 7 | 7
Local anesthesia, by infiltration 7 | 14
Local anesthetic intrathecal block 7 | 7
Postherpetic neuralgia 7 | 11
Premature ejaculation 7 | 16
Prevention of Seizures following Cranial Trauma or Surgery 7 | 7
Seizures 7 | 596
Seizures in Neurosurgery 7 | 7
Status Epilepticus 7 | 98
malignant mesothelioma 7 | 3,232
oligodendroglioma 7 | 2,850
Administration of Corneal Anesthesia 6 | 6
Hemorrhoids 6 | 13
Infestation by Phthirus pubis 6 | 7
Infestation by Sarcoptes scabiei var hominis 6 | 7
Liver cancer 6 | 604
Local Anesthesia for Endotracheal Intubation 6 | 6
Local Anesthesia for Urethral Pain 6 | 6
Neuralgia 6 | 20
Paroxysmal atrial fibrillation 6 | 14
Pediculosis capitis 6 | 7
Pruritus ani 6 | 14
Regional Anesthesia for Ophthalmologic Surgery 6 | 6
Urethritis 6 | 10
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
ovarian cancer 6 | 8,520
primitive neuroectodermal tumor 6 | 3,035
Angina Pectoris 5 | 32
Autistic Disorder 5 | 364
Brugada Syndrome (disorder) 5 | 15
Brugada syndrome 5 | 29
Cerebellar Ataxia 5 | 304
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Parkinsonism 5 | 18
Skin cancer 5 | 469
Spasticity 5 | 26
Tremor 5 | 113
astrocytic glioma 5 | 2,597
Abnormal behavior 4 | 52
Electroencephalogram abnormal 4 | 101
Infantile onset 4 | 238
Malaria 4 | 160
Neuropathy 4 | 261
Variable expressivity 4 | 157
breast carcinoma 4 | 1,638
lung adenocarcinoma 4 | 2,716
subependymal giant cell astrocytoma 4 | 2,287

Tissue

Endocrine System 22 | 18,159
Nervous System 20 | 16,725
Digestive Tract 19 | 17,369
Female tissues 19 | 17,400
Respiratory system 19 | 16,393
Blood and immune system 18 | 16,909
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Cardiovascular System 16 | 15,192

Target Family

Ion Channel 22 | 344

GO Function

voltage-gated sodium channel a... 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 4 subunit alpha SCN4A Tclin Ion Channel -2.57811 366.4 57
Sodium channel protein type 1 subunit alpha SCN1A Tclin Ion Channel -2.74061 554.6 131
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 HCN3 Tclin Ion Channel -1.65805 34.9 216
Sodium channel protein type 9 subunit alpha SCN9A Tclin Ion Channel -2.57994 379.2 327
Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I Tclin Ion Channel -1.95446 85.6 79
Sodium channel subunit beta-3 SCN3B Tbio Ion Channel -0.97654 10.5 71
Sodium channel protein type 7 subunit alpha SCN7A Tclin Ion Channel -0.99420 8.52 83
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 HCN1 Tclin Ion Channel -0.77815 5.03 260
Cation channel sperm-associated protein 2 CATSPER2 Tchem Ion Channel -1.36696 22.9 118