Development Level

Tbio 21 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

abnormal bone structure 4 | 187
preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal maxilla morphology 1 | 17
abnormal pericardium morpholog... 1 | 26
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
fused cornea and lens 1 | 5
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 36
increased total body fat amoun... 1 | 134
pallor 1 | 34

Disease

Carcinoma 21 | 11,493
osteosarcoma 20 | 7,950
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 15 | 5,792
ovarian cancer 14 | 8,520
medulloblastoma, large-cell 13 | 6,241
psoriasis 13 | 6,694
ependymoma 12 | 4,679
Astrocytoma, Pilocytic 11 | 3,081
Kidney cancer 10 | 2,613
adult high grade glioma 10 | 3,801
lung carcinoma 10 | 2,843
primitive neuroectodermal tumor 10 | 3,035
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
subependymal giant cell astrocytoma 9 | 2,287
Breast cancer 8 | 3,578
lung adenocarcinoma 8 | 2,716
lung cancer 8 | 4,740
malignant mesothelioma 8 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Pick disease 6 | 1,894
breast carcinoma 6 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
non-small cell lung cancer 6 | 2,890
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
tuberculosis 5 | 2,010
Cancer 4 | 2,499
Rheumatoid arthritis 4 | 1,191
acute quadriplegic myopathy 4 | 1,158
cystic fibrosis 4 | 1,696
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
spina bifida 4 | 1,074
ulcerative colitis 4 | 1,819
Chondrosarcoma 3 | 21
Endometriosis 3 | 540
Gaucher disease type 1 3 | 180
Neurodegenerative disease 3 | 414
Renal Cell Carcinoma 3 | 214
Schizophrenia 3 | 1,160
Short stature 3 | 531
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
gastric carcinoma 3 | 807
interstitial cystitis 3 | 2,312
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Carcinoma, Renal Cell 2 | 124
Cardiovascular system disease 2 | 246
Chronic Lymphocytic Leukemia 2 | 262
Cognitive delay 2 | 608
Constipation 2 | 181
Crohn's disease 2 | 321
Ectopic Tissue 2 | 14
Epilepsy 2 | 792
Global developmental delay 2 | 608
Heart disease 2 | 306
Hypertension 2 | 396
Intellectual disability 2 | 1,016
Large intestine cancer 2 | 126
Leprosy 2 | 73
Liver Cirrhosis, Experimental 2 | 769
Liver cancer 2 | 604
Mental and motor retardation 2 | 608
Nerve Degeneration 2 | 121
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Neuropathy 2 | 261
Nonsyndromic deafness 2 | 142
Parkinson's disease 2 | 392
Respiratory Failure 2 | 104
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Skeletal muscle atrophy 2 | 139
Small head 2 | 374
atypical teratoid/rhabdoid tumor 2 | 357
cutaneous lupus erythematosus 2 | 1,057
fibroadenoma 2 | 559
group 4 medulloblastoma 2 | 1,855
muscle degeneration 2 | 139
Craniofacial hyperostosis 1 | 11
Fused cervical vertebrae 1 | 5
Irregular metacarpals 1 | 2
Long metacarpals 1 | 2
Posterior vertebral hypoplasia 1 | 3
Short distal phalanx of hallux 1 | 2
Thick craniofacial bones 1 | 11

Tissue

Blood and immune system 25 | 16,909
Cardiovascular System 25 | 15,192
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678

Target Family

Non-IDG 15 | 12,091
Kinase 5 | 634
Enzyme 4 | 4,145
Transcription Factor 1 | 1,400

GO Function

Rho GTPase binding 25 | 25
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho guanine nucleotide exchange factor 2 ARHGEF2 Tbio Non-IDG -1.64721 53.8 302
Protein diaphanous homolog 3 DIAPH3 Tbio Non-IDG -1.73720 59.7 189
Protein diaphanous homolog 2 DIAPH2 Tbio Non-IDG -1.70372 49.0 172
Protein diaphanous homolog 1 DIAPH1 Tbio Non-IDG -1.73502 50.0 255
A-kinase anchor protein 13 AKAP13 Tbio Enzyme -2.46756 291.7 156
Ras GTPase-activating-like protein IQGAP3 IQGAP3 Tbio Enzyme -1.11229 13.6 120
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.37859 20.9 98
Rho guanine nucleotide exchange factor 16 ARHGEF16 Tbio Non-IDG -2.37388 232.3 97
Rho-associated protein kinase 2 ROCK2 Tclin Kinase -2.48707 283.0 490