Development Level

Tbio 1,335 | 10,625
Tchem 299 | 1,890
Tdark 203 | 7,003
Tclin 69 | 602

Collection

Eligible Kinase Proteins 13 | 134
Eligible Ion Channel Proteins 7 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 104 | 633
embryonic lethality prior to t... 39 | 187
embryonic lethality prior to o... 32 | 148
preweaning lethality, incomple... 31 | 260
decreased total body fat amoun... 28 | 186
abnormal behavior 23 | 226
decreased body weight 23 | 174
decreased lean body mass 19 | 195
increased grip strength 19 | 83
decreased bone mineral density 18 | 126
increased mean corpuscular hem... 18 | 93
abnormal embryo size 17 | 112
abnormal bone structure 16 | 131
abnormal retina morphology 16 | 100
decreased bone mineral content 16 | 157
increased or absent threshold ... 16 | 128
hyperactivity 15 | 108
hypoactivity 15 | 89
increased circulating alkaline... 15 | 119
decreased grip strength 14 | 123
increased lean body mass 14 | 107
decreased circulating glucose ... 12 | 121
decreased body length 11 | 108
increased bone mineral content 11 | 92
abnormal lens morphology 10 | 73
decreased circulating triglyce... 10 | 83
decreased rib number 10 | 59
enlarged heart 10 | 111
abnormal neural tube closure 9 | 37
decreased caudal vertebrae num... 9 | 49
decreased circulating alanine ... 9 | 53
decreased fasted circulating g... 9 | 49
decreased startle reflex 9 | 48
impaired glucose tolerance 9 | 52
increased circulating HDL chol... 9 | 63
increased mean corpuscular vol... 9 | 91
male infertility 9 | 62
abnormal bone mineralization 8 | 55
decreased circulating HDL chol... 8 | 77
improved glucose tolerance 8 | 56
prenatal lethality prior to he... 8 | 64
abnormal behavioral response t... 7 | 52
abnormal gait 7 | 51
abnormal hindbrain development 7 | 24
abnormal midbrain development 7 | 22
decreased circulating aspartat... 7 | 27
decreased circulating calcium ... 7 | 33
decreased erythrocyte cell num... 7 | 43
decreased leukocyte cell numbe... 7 | 54
decreased prepulse inhibition 7 | 52
increased body weight 7 | 42
increased bone mineral density 7 | 52
increased exploration in new e... 7 | 56
increased fasted circulating g... 7 | 68
increased heart weight 7 | 37
increased total body fat amoun... 7 | 57
short tibia 7 | 82
thrombocytopenia 7 | 46
abnormal retinal pigmentation 6 | 61
abnormal seminal vesicle morph... 6 | 47
decreased NK T cell number 6 | 28
decreased circulating chloride... 6 | 32
decreased circulating choleste... 6 | 85
decreased circulating insulin ... 6 | 75
decreased eosinophil cell numb... 6 | 41
decreased hemoglobin content 6 | 53
decreased lumbar vertebrae num... 6 | 62
increased circulating calcium ... 6 | 32
increased circulating choleste... 6 | 53
increased sacral vertebrae num... 6 | 62
abnormal QRS complex 5 | 25
abnormal heart morphology 5 | 51
abnormal sleep behavior 5 | 63
decreased NK cell number 5 | 16
decreased circulating alkaline... 5 | 41
decreased circulating fructosa... 5 | 31
decreased circulating serum al... 5 | 79
decreased heart weight 5 | 44
decreased mean corpuscular vol... 5 | 50
enlarged lymph nodes 5 | 27
increased T cell number 5 | 15
increased blood urea nitrogen ... 5 | 44
increased circulating aspartat... 5 | 17
increased circulating iron lev... 5 | 25
increased circulating phosphat... 5 | 24
increased hemoglobin content 5 | 45
increased leukocyte cell numbe... 5 | 37
increased startle reflex 5 | 38
abnormal vibrissa morphology 4 | 17
decreased T cell number 4 | 31
decreased circulating glycerol... 4 | 19
decreased circulating sodium l... 4 | 18
decreased lactate dehydrogenas... 4 | 14
increased NK T cell number 4 | 11
increased circulating total pr... 4 | 20
increased mean platelet volume 4 | 19
increased prepulse inhibition 4 | 21
limb grasping 4 | 35
long tibia 4 | 13
thrombocytosis 4 | 23

Disease

ovarian cancer 1,177 | 8,484
osteosarcoma 981 | 7,933
medulloblastoma, large-cell 802 | 6,234
psoriasis 777 | 6,685
glioblastoma 764 | 5,572
lung cancer 670 | 4,466
atypical teratoid / rhabdoid tumor 546 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 448 | 3,289
malignant mesothelioma 424 | 3,162
Breast cancer 401 | 3,094
pilocytic astrocytoma 396 | 3,086
invasive ductal carcinoma 394 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 378 | 2,988
non-small cell lung cancer 375 | 2,798
pediatric high grade glioma 367 | 2,712
Cancer 364 | 2,346
lung adenocarcinoma 351 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 349 | 2,956
oligodendroglioma 347 | 2,849
primitive neuroectodermal tumor 335 | 3,031
ependymoma 317 | 2,514
pancreatic cancer 315 | 2,300
lung carcinoma 309 | 2,844
subependymal giant cell astrocytoma 305 | 2,287
Multiple myeloma 298 | 1,327
Carcinoma 286 | 2,147
ulcerative colitis 284 | 2,087
diabetes mellitus 278 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 273 | 1,795
astrocytoma 266 | 1,493
interstitial cystitis 262 | 2,299
group 3 medulloblastoma 261 | 2,254
astrocytic glioma 253 | 2,241
Pick disease 249 | 1,893
group 4 medulloblastoma 239 | 1,875
adult high grade glioma 236 | 2,148
acute quadriplegic myopathy 231 | 1,157
juvenile dermatomyositis 214 | 1,189
ductal carcinoma in situ 210 | 1,745
pituitary cancer 210 | 1,972
tuberculosis 206 | 1,557
colon cancer 203 | 1,475
Rheumatoid Arthritis 199 | 1,160
breast carcinoma 198 | 1,614
posterior fossa group A ependymoma 197 | 1,511
dermatomyositis 181 | 933
adrenocortical carcinoma 175 | 1,427
Waldenstrons macroglobulinemia 173 | 765
primary pancreatic ductal adenocarcinoma 172 | 1,271
cystic fibrosis 170 | 1,665
medulloblastoma 169 | 1,524
cutaneous lupus erythematosus 151 | 1,056
sonic hedgehog group medulloblastoma 150 | 1,482
active Crohn's disease 139 | 918
spina bifida 138 | 1,064
atypical teratoid/rhabdoid tumor 133 | 1,095
posterior fossa group B ependymoma 125 | 1,530
Alzheimer's disease 116 | 644
primary Sjogren syndrome 114 | 789
non primary Sjogren syndrome sicca 112 | 840
Atopic dermatitis 106 | 944
IGA Glomerulonephritis 106 | 454
nasopharyngeal carcinoma 106 | 1,056
esophageal adenocarcinoma 105 | 737
Duchenne muscular dystrophy 101 | 602
gastric carcinoma 101 | 832
acute myeloid leukemia 96 | 780
aldosterone-producing adenoma 93 | 664
tuberculosis and treatment for 6 months 92 | 686
progressive supranuclear palsy 91 | 674
Intellectual disability 90 | 573
Obesity 89 | 616
Down syndrome 87 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 81 | 499
Endometriosis 80 | 535
Neurodegenerative disease 77 | 383
Prostatic Neoplasms 75 | 471
Mammary Neoplasms 72 | 410
Amyotrophic Lateral Sclerosis 70 | 431
pancreatic carcinoma 70 | 567
Schizophrenia 66 | 501
mucosa-associated lymphoid tissue lymphoma 64 | 480
hereditary spastic paraplegia 61 | 313
Multiple Sclerosis 59 | 498
Parkinson's disease 56 | 364
Polycystic Ovary Syndrome 55 | 332
Kidney disease 53 | 396
fibroadenoma 53 | 557
active ulcerative colitis 52 | 477
Epilepsy 51 | 346
inflammatory breast cancer 51 | 404
non-small cell lung carcinoma 49 | 413
Stomach Neoplasms 48 | 282
sarcoidosis 48 | 358
Vascular disease 47 | 281
gastric cancer 47 | 430
Asthma 45 | 349
hepatocellular carcinoma 45 | 532
Peripheral Neuropathy 41 | 303
Autistic Disorder 39 | 320

Tissue

Nervous System 1,889 | 18,561
Digestive Tract 1,888 | 18,473
Female tissues 1,887 | 18,647
Urinary Tract 1,886 | 18,444
Liver and Pancreas 1,885 | 18,136
Blood and immune system 1,884 | 17,995
Endocrine System 1,884 | 18,512
Male tissues 1,884 | 17,969
Cardiovascular System 1,881 | 17,958
Skin and soft tissues 1,873 | 18,115
Respiratory system 1,872 | 17,484

Target Family

Non-IDG 1,099 | 11,971
Enzyme 541 | 4,146
Transporter 111 | 473
Kinase 79 | 634
Ion Channel 28 | 341
Transcription Factor 21 | 1,400
GPCR 14 | 406
Epigenetic 11 | 242
Nuclear Receptor 2 | 48

GO Component

membrane 1,906 | 1,906
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability