Development Level

Tbio 140 | 11,445
Tchem 22 | 1,598
Tdark 15 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 25 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 6 | 499
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased total body fat amoun... 4 | 207
male infertility 4 | 123
abnormal behavior 3 | 298
abnormal head morphology 3 | 10
abnormal tail morphology 3 | 25
cataract 3 | 92
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
increased fasted circulating g... 3 | 76
abnormal coat-hair pigmentatio... 2 | 64
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
decreased body length 2 | 101
decreased circulating calcium ... 2 | 36
decreased circulating total pr... 2 | 49
decreased heart left ventricle... 2 | 28
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased mean corpuscular vol... 2 | 92
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased thermal nociceptive ... 1 | 9
long tibia 1 | 25
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
syndactyly 1 | 23
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 126 | 11,493
ovarian cancer 121 | 8,520
medulloblastoma, large-cell 101 | 6,241
group 3 medulloblastoma 100 | 4,104
atypical teratoid / rhabdoid tumor 93 | 5,112
osteosarcoma 92 | 7,950
glioblastoma 89 | 5,792
psoriasis 86 | 6,694
lung cancer 82 | 4,740
primitive neuroectodermal tumor 77 | 3,035
Breast cancer 70 | 3,578
ependymoma 67 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 64 | 3,291
malignant mesothelioma 63 | 3,232
adult high grade glioma 62 | 3,801
non-small cell lung cancer 61 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,989
adrenocortical carcinoma 51 | 1,428
Kidney cancer 47 | 2,613
invasive ductal carcinoma 47 | 2,951
lung adenocarcinoma 44 | 2,716
oligodendroglioma 42 | 2,850
colon cancer 38 | 1,478
breast carcinoma 35 | 1,638
nasopharyngeal carcinoma 35 | 1,058
ductal carcinoma in situ 34 | 1,745
pancreatic cancer 32 | 2,398
Intellectual disability 30 | 1,016
Cancer 29 | 2,499
Pick disease 29 | 1,894
astrocytic glioma 29 | 2,597
Astrocytoma, Pilocytic 28 | 3,081
Atopic dermatitis 26 | 952
Endometriosis 26 | 540
Multiple myeloma 25 | 1,332
Waldenstrons macroglobulinemia 23 | 765
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mental and motor retardation 22 | 608
Small head 20 | 374
Microcephaly 19 | 166
Short stature 19 | 531
subependymal giant cell astrocytoma 19 | 2,287
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
tuberculosis 18 | 2,010
ulcerative colitis 18 | 1,819
dermatomyositis 17 | 966
pediatric high grade glioma 16 | 1,064
Autosomal recessive predisposition 15 | 1,442
Rheumatoid arthritis 14 | 1,191
acute quadriplegic myopathy 14 | 1,158
astrocytoma 14 | 1,146
pituitary cancer 14 | 1,972
interstitial cystitis 13 | 2,312
Epilepsy 12 | 792
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Schizophrenia 12 | 1,160
Seizures 12 | 596
juvenile dermatomyositis 12 | 1,187
primary Sjogren syndrome 12 | 735
Downward slant of palpebral fissure 11 | 158
diabetes mellitus 11 | 1,728
group 4 medulloblastoma 11 | 1,855
progressive supranuclear palsy 11 | 676
tuberculosis and treatment for 6 months 11 | 409
Anteverted nostril 10 | 191
Fetal Growth Retardation 10 | 189
Glaucoma 10 | 239
Infant, Small for Gestational Age 10 | 176
Intrauterine retardation 10 | 176
posterior fossa group A ependymoma 10 | 468
Dilated ventricles (finding) 9 | 121
Joubert syndrome 9 | 66
Lissencephaly 9 | 69
acute myeloid leukemia 9 | 783
non primary Sjogren syndrome sicca 9 | 891
Bilateral fifth finger clinodactyly 8 | 110
Cataract 8 | 297
Curvature of little finger 8 | 110
Lens Opacities 8 | 231
Seckel syndrome 8 | 34
Severe mental retardation (I.Q. 20-34) 8 | 99
active Crohn's disease 8 | 922
gastric carcinoma 8 | 807
hereditary spastic paraplegia 8 | 318
Agenesis of corpus callosum 7 | 83
Bipolar Disorder 7 | 666
Congenital hypoplasia of penis 7 | 176
Obesity 7 | 678
Orbital separation excessive 7 | 244
Short neck 7 | 140
Sloping forehead 7 | 46

Tissue

Endocrine System 181 | 18,159
Blood and immune system 180 | 16,909
Digestive Tract 180 | 17,369
Female tissues 180 | 17,400
Liver and Pancreas 180 | 16,750
Male tissues 180 | 17,142
Nervous System 180 | 16,725
Respiratory system 180 | 16,393
Skin and soft tissues 180 | 17,230
Urinary Tract 180 | 16,678
Cardiovascular System 177 | 15,192

Target Family

Non-IDG 150 | 12,091
Enzyme 16 | 4,145
Kinase 14 | 634
Epigenetic 1 | 242

Reactome Pathway

Mitotic Prometaphase 181 | 181
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability