Development Level

Tbio 10,227 | 11,445
Tdark 3,998 | 6,588
Tchem 1,449 | 1,598
Tclin 506 | 613

Collection

RFA-RM-18-021 246 | 328
Kinase: IDG Consortium (Target... 112 | 125
GPCR: IDG Consortium (Targets) 71 | 126
Ion Channel: IDG Consortium (T... 70 | 99
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 464 | 499
abnormal behavior 276 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 182 | 210
abnormal bone structure 169 | 187
decreased vertical activity 168 | 208
increased lean body mass 160 | 172
decreased body weight 152 | 161
abnormal heart morphology 140 | 162
hyperactivity 133 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 119 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 111 | 122
decreased bone mineral density 110 | 126
male infertility 105 | 123
increased startle reflex 103 | 112
decreased grip strength 102 | 116
embryonic growth retardation 100 | 106
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 94 | 114
decreased body length 93 | 101
increased or absent threshold ... 92 | 101
short tibia 91 | 97
increased mean corpuscular hem... 90 | 96
decreased circulating choleste... 89 | 93
cataract 86 | 92
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 86 | 87
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased mean corpuscular vol... 75 | 79
decreased circulating serum al... 73 | 82
decreased lymphocyte cell numb... 72 | 83
decreased circulating triglyce... 71 | 79
increased circulating HDL chol... 71 | 80
increased bone mineral density 70 | 72
improved glucose tolerance 69 | 79
decreased leukocyte cell numbe... 68 | 73
decreased startle reflex 68 | 75
increased fasted circulating g... 67 | 76
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
impaired glucose tolerance 66 | 75
small superior vagus ganglion 65 | 74
decreased circulating insulin ... 64 | 76
abnormal eye morphology 63 | 68
abnormal gait 62 | 69
decreased hemoglobin content 62 | 68
abnormal coat-hair pigmentatio... 61 | 64
abnormal sleep behavior 61 | 70
decreased erythrocyte cell num... 61 | 62
increased circulating choleste... 60 | 66
edema 58 | 59
increased circulating sodium l... 58 | 71
increased heart weight 58 | 62
abnormal behavioral response t... 57 | 66
decreased fasted circulating g... 57 | 65
abnormal kidney morphology 56 | 65
small testis 55 | 58
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 52 | 53
female infertility 50 | 60
increased monocyte cell number 50 | 63
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 48 | 50
decreased blood urea nitrogen ... 47 | 51
hydrometra 47 | 53
abnormal neural tube closure 45 | 46
decreased circulating alkaline... 45 | 46
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
decreased circulating total pr... 44 | 49
decreased hematocrit 43 | 46
increased blood urea nitrogen ... 43 | 48
increased leukocyte cell numbe... 43 | 47
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
decreased red blood cell distr... 41 | 41
increased mean platelet volume 41 | 45
increased neutrophil cell numb... 41 | 46
abnormal testis morphology 40 | 43
decreased neutrophil cell numb... 39 | 42
tremors 39 | 39
abnormal bone mineralization 38 | 38
increased circulating triglyce... 38 | 42
increased grip strength 37 | 41
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
enlarged spleen 36 | 41
increased circulating chloride... 36 | 41
increased erythrocyte cell num... 36 | 39
increased mean corpuscular hem... 35 | 36
decreased circulating creatini... 34 | 39

Disease

Carcinoma 9,816 | 11,493
ovarian cancer 8,017 | 8,520
osteosarcoma 7,429 | 7,950
medulloblastoma, large-cell 5,692 | 6,241
psoriasis 5,688 | 6,694
glioblastoma 5,358 | 5,792
atypical teratoid / rhabdoid tumor 4,689 | 5,112
lung cancer 4,427 | 4,740
ependymoma 4,230 | 4,679
group 3 medulloblastoma 3,775 | 4,104
adult high grade glioma 3,431 | 3,801
Breast cancer 3,294 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,097 | 3,291
malignant mesothelioma 3,081 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,797 | 2,989
invasive ductal carcinoma 2,779 | 2,951
Astrocytoma, Pilocytic 2,771 | 3,081
primitive neuroectodermal tumor 2,767 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,754 | 2,955
non-small cell lung cancer 2,689 | 2,890
oligodendroglioma 2,583 | 2,850
lung carcinoma 2,542 | 2,843
lung adenocarcinoma 2,467 | 2,716
astrocytic glioma 2,367 | 2,597
Cancer 2,290 | 2,499
Kidney cancer 2,273 | 2,613
pancreatic cancer 2,236 | 2,398
subependymal giant cell astrocytoma 2,123 | 2,287
interstitial cystitis 2,104 | 2,312
tuberculosis 1,924 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,909 | 1,962
Pick disease 1,777 | 1,894
pituitary cancer 1,762 | 1,972
group 4 medulloblastoma 1,712 | 1,855
ulcerative colitis 1,707 | 1,819
ductal carcinoma in situ 1,626 | 1,745
cystic fibrosis 1,558 | 1,696
breast carcinoma 1,514 | 1,638
diabetes mellitus 1,434 | 1,728
colon cancer 1,358 | 1,478
adrenocortical carcinoma 1,354 | 1,428
Autosomal recessive predisposition 1,330 | 1,442
Multiple myeloma 1,312 | 1,332
juvenile dermatomyositis 1,162 | 1,187
Rheumatoid arthritis 1,125 | 1,191
acute quadriplegic myopathy 1,123 | 1,158
astrocytoma 1,095 | 1,146
primary pancreatic ductal adenocarcinoma 1,054 | 1,109
spina bifida 1,025 | 1,074
Schizophrenia 993 | 1,160
pediatric high grade glioma 993 | 1,064
cutaneous lupus erythematosus 978 | 1,057
nasopharyngeal carcinoma 952 | 1,058
dermatomyositis 951 | 966
Intellectual disability 938 | 1,016
active Crohn's disease 851 | 922
Atopic dermatitis 823 | 952
non primary Sjogren syndrome sicca 812 | 891
acute myeloid leukemia 760 | 783
Waldenstrons macroglobulinemia 758 | 765
gastric carcinoma 751 | 807
Liver Cirrhosis, Experimental 728 | 769
Epilepsy 721 | 792
primary Sjogren syndrome 709 | 735
active ulcerative colitis 701 | 764
esophageal adenocarcinoma 695 | 737
medulloblastoma 660 | 720
progressive supranuclear palsy 641 | 676
aldosterone-producing adenoma 627 | 665
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Obesity 591 | 678
Alzheimer's disease 582 | 658
Cognitive delay 578 | 608
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Duchenne muscular dystrophy 573 | 601
Melanoma 556 | 711
Seizures 551 | 596
Bipolar Disorder 550 | 666
Muscle hypotonia 543 | 571
pancreatic carcinoma 540 | 562
hepatocellular carcinoma 530 | 547
fibroadenoma 506 | 559
Short stature 501 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 510
Endometriosis 490 | 540
Liver cancer 485 | 604
Prostatic Neoplasms 468 | 495
Down syndrome 465 | 499
Multiple Sclerosis 461 | 540
mucosa-associated lymphoid tissue lymphoma 448 | 484
chronic rhinosinusitis 444 | 512
gastric cancer 444 | 459
posterior fossa group A ependymoma 432 | 468
sonic hedgehog group medulloblastoma 431 | 467
Amyotrophic lateral sclerosis 427 | 451

Tissue

Endocrine System 15,887 | 18,159
Digestive Tract 15,666 | 17,369
Female tissues 15,649 | 17,400
Skin and soft tissues 15,623 | 17,230
Male tissues 15,518 | 17,142
Blood and immune system 15,515 | 16,909
Liver and Pancreas 15,400 | 16,750
Nervous System 15,349 | 16,725
Urinary Tract 15,333 | 16,678
Respiratory system 15,167 | 16,393
Cardiovascular System 14,336 | 15,192

Target Family

Non-IDG 9,417 | 12,091
Enzyme 3,705 | 4,145
Transcription Factor 1,211 | 1,400
Kinase 588 | 634
Transporter 398 | 473
GPCR 274 | 408
Ion Channel 246 | 344
Epigenetic 226 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 37 | 38
oGPCR 33 | 421

HCA RNA Cell Line

U-937 16,180 | 16,180
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability