Development Level

Tbio 9,371 | 10,625
Tdark 4,527 | 7,003
Tchem 1,652 | 1,890
Tclin 486 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 81 | 102
GPCR: IDG Consortium (Targets) 67 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 26

IMPC Phenotype

preweaning lethality, complete... 608 | 633
preweaning lethality, incomple... 241 | 260
abnormal behavior 215 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 177 | 186
decreased body weight 169 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 115 | 128
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 119
decreased circulating glucose ... 109 | 121
decreased grip strength 109 | 123
abnormal embryo size 103 | 112
decreased body length 103 | 108
hyperactivity 101 | 108
increased lean body mass 96 | 107
abnormal retina morphology 94 | 100
enlarged heart 92 | 111
increased mean corpuscular hem... 89 | 93
increased bone mineral content 85 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 83 | 85
hypoactivity 80 | 89
short tibia 80 | 82
decreased circulating triglyce... 77 | 83
decreased circulating HDL chol... 75 | 77
decreased circulating serum al... 72 | 79
increased grip strength 72 | 83
abnormal lens morphology 68 | 73
decreased circulating insulin ... 66 | 75
increased fasted circulating g... 65 | 68
increased circulating sodium l... 64 | 71
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 56 | 61
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
male infertility 55 | 62
abnormal bone mineralization 52 | 55
increased circulating HDL chol... 52 | 63
increased total body fat amoun... 51 | 57
decreased leukocyte cell numbe... 50 | 54
impaired glucose tolerance 50 | 52
abnormal coat-hair pigmentatio... 48 | 54
decreased mean corpuscular vol... 48 | 50
decreased prepulse inhibition 48 | 52
increased circulating choleste... 48 | 53
decreased circulating alanine ... 47 | 53
increased bone mineral density 47 | 52
increased exploration in new e... 47 | 56
decreased hemoglobin content 46 | 53
decreased startle reflex 46 | 48
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
improved glucose tolerance 45 | 56
abnormal behavioral response t... 44 | 52
abnormal heart morphology 42 | 51
decreased fasted circulating g... 42 | 49
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
thrombocytopenia 42 | 46
increased hemoglobin content 41 | 45
decreased circulating total pr... 40 | 41
decreased erythrocyte cell num... 40 | 43
increased circulating chloride... 39 | 43
abnormal eye morphology 38 | 38
decreased circulating alkaline... 38 | 41
increased rib number 38 | 41
abnormal seminal vesicle morph... 37 | 47
decreased eosinophil cell numb... 37 | 41
decreased heart weight 37 | 44
decreased neutrophil cell numb... 37 | 37
decreased circulating LDL chol... 36 | 37
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
increased heart weight 34 | 37
small testis 34 | 37
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
tremors 33 | 34
increased startle reflex 32 | 38
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
increased hematocrit 31 | 36
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
abnormal testis morphology 29 | 30
decreased T cell number 29 | 31
decreased blood urea nitrogen ... 29 | 31
abnormal epididymis morphology 28 | 31
cardiovascular system phenotyp... 28 | 35
decreased B cell number 28 | 30
decreased circulating chloride... 28 | 32
decreased NK T cell number 27 | 28
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,920 | 8,491
osteosarcoma 7,242 | 7,933
medulloblastoma, large-cell 5,702 | 6,234
psoriasis 5,676 | 6,685
glioblastoma 5,169 | 5,572
lung cancer 4,142 | 4,473
atypical teratoid / rhabdoid tumor 4,054 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,052 | 3,289
malignant mesothelioma 3,014 | 3,163
Breast cancer 2,906 | 3,098
primitive neuroectodermal tumor 2,802 | 3,031
pilocytic astrocytoma 2,785 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,745 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,718 | 2,956
invasive ductal carcinoma 2,713 | 2,950
oligodendroglioma 2,621 | 2,849
non-small cell lung cancer 2,533 | 2,798
pediatric high grade glioma 2,512 | 2,712
lung carcinoma 2,487 | 2,844
lung adenocarcinoma 2,414 | 2,714
ependymoma 2,350 | 2,514
subependymal giant cell astrocytoma 2,121 | 2,287
pancreatic cancer 2,113 | 2,300
Cancer 2,081 | 2,346
group 3 medulloblastoma 2,078 | 2,254
astrocytic glioma 2,070 | 2,241
interstitial cystitis 2,013 | 2,299
adult high grade glioma 1,925 | 2,148
ulcerative colitis 1,858 | 2,087
Carcinoma 1,850 | 2,147
pituitary cancer 1,774 | 1,972
Pick disease 1,771 | 1,893
group 4 medulloblastoma 1,754 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,681 | 1,795
ductal carcinoma in situ 1,611 | 1,745
cystic fibrosis 1,514 | 1,670
breast carcinoma 1,489 | 1,614
tuberculosis 1,411 | 1,563
astrocytoma 1,404 | 1,493
medulloblastoma 1,402 | 1,524
posterior fossa group B ependymoma 1,394 | 1,530
sonic hedgehog group medulloblastoma 1,373 | 1,482
posterior fossa group A ependymoma 1,355 | 1,511
colon cancer 1,327 | 1,475
adrenocortical carcinoma 1,315 | 1,427
diabetes mellitus 1,302 | 1,663
Multiple myeloma 1,290 | 1,327
primary pancreatic ductal adenocarcinoma 1,213 | 1,271
juvenile dermatomyositis 1,132 | 1,189
acute quadriplegic myopathy 1,102 | 1,157
Rheumatoid Arthritis 1,067 | 1,170
atypical teratoid/rhabdoid tumor 1,015 | 1,095
spina bifida 1,006 | 1,064
nasopharyngeal carcinoma 950 | 1,056
dermatomyositis 932 | 966
cutaneous lupus erythematosus 896 | 1,056
active Crohn's disease 828 | 918
Atopic dermatitis 802 | 944
gastric carcinoma 779 | 832
non primary Sjogren syndrome sicca 754 | 840
acute myeloid leukemia 740 | 785
Waldenstrons macroglobulinemia 734 | 764
primary Sjogren syndrome 706 | 788
esophageal adenocarcinoma 672 | 737
tuberculosis and treatment for 6 months 657 | 686
progressive supranuclear palsy 642 | 674
aldosterone-producing adenoma 623 | 664
Alzheimer's disease 564 | 644
Duchenne muscular dystrophy 551 | 602
Intellectual disability 538 | 573
pancreatic carcinoma 524 | 567
hepatocellular carcinoma 523 | 550
Obesity 519 | 616
Down syndrome 517 | 548
fibroadenoma 510 | 557
Endometriosis 484 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 499
chronic rhinosinusitis 462 | 512
Prostatic Neoplasms 430 | 471
IGA Glomerulonephritis 423 | 454
active ulcerative colitis 423 | 477
Schizophrenia 422 | 503
gastric cancer 407 | 436
Multiple Sclerosis 404 | 498
Amyotrophic Lateral Sclerosis 402 | 432
mucosa-associated lymphoid tissue lymphoma 398 | 480
Mammary Neoplasms 381 | 410
inflammatory breast cancer 362 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 347 | 413
sarcoidosis 327 | 368
Kidney disease 325 | 397
glioblastoma multiforme 319 | 347
Parkinson's disease 316 | 364
tuberculosis and treatment for 3 months 303 | 327
Polycystic Ovary Syndrome 302 | 334
hereditary spastic paraplegia 302 | 313
Epilepsy 300 | 346
urothelial carcinoma 294 | 318
nephrosclerosis 273 | 329

Tissue

Nervous System 15,802 | 18,560
Female tissues 15,781 | 18,646
Digestive Tract 15,773 | 18,472
Endocrine System 15,768 | 18,511
Urinary Tract 15,709 | 18,443
Liver and Pancreas 15,681 | 18,135
Male tissues 15,664 | 17,968
Cardiovascular System 15,627 | 17,957
Blood and immune system 15,620 | 17,994
Skin and soft tissues 15,597 | 18,114
Respiratory system 15,451 | 17,483

Target Family

Non-IDG 9,326 | 11,969
Enzyme 3,636 | 4,146
Transcription Factor 1,241 | 1,400
Kinase 586 | 634
Transporter 397 | 473
Ion Channel 272 | 341
GPCR 258 | 408
Epigenetic 225 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 35 | 38
oGPCR 20 | 421

HCA RNA Cell Line

T-47d 16,036 | 16,036
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Little elongation complex subunit 2 ICE2 Tbio Non-IDG -1.02690 9.65 80
Tyrosine-protein kinase JAK2 JAK2 Tclin Kinase -3.50695 3102.9 750
Transcription factor MafK MAFK Tchem Transcription Factor -1.54665 32.5 81
Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 Tclin Ion Channel -1.91443 74.3 261
Ephrin-A1 EFNA1 Tbio Kinase -1.99448 94.5 212
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.70117 462.2 1672