Development Level

Tbio 788 | 11,651
Tdark 186 | 6,593
Tchem 79 | 1,388
Tclin 21 | 612

Collection

RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 63 | 979
preweaning lethality, incomple... 49 | 499
embryonic lethality prior to t... 25 | 278
abnormal behavior 23 | 298
decreased total body fat amoun... 23 | 207
increased lean body mass 22 | 172
abnormal embryo size 20 | 220
enlarged heart 20 | 210
decreased body weight 19 | 161
abnormal bone structure 17 | 187
decreased vertical activity 16 | 208
hyperactivity 14 | 148
increased or absent threshold ... 14 | 101
decreased bone mineral density 13 | 126
embryonic lethality prior to o... 13 | 239
decreased lean body mass 12 | 135
decreased prepulse inhibition 12 | 82
increased circulating alkaline... 12 | 122
abnormal seminal vesicle morph... 10 | 114
decreased circulating triglyce... 10 | 79
embryonic growth retardation 10 | 106
increased heart weight 10 | 62
small testis 10 | 58
abnormal coat-hair pigmentatio... 9 | 64
abnormal eye morphology 9 | 68
abnormal retina morphology 9 | 71
decreased circulating choleste... 9 | 93
decreased startle reflex 9 | 75
hypoactivity 9 | 132
increased mean corpuscular vol... 9 | 92
increased startle reflex 9 | 112
increased total body fat amoun... 9 | 134
decreased bone mineral content 8 | 151
decreased circulating glucose ... 8 | 126
decreased erythrocyte cell num... 8 | 62
decreased hemoglobin content 8 | 68
prenatal lethality prior to he... 8 | 87
abnormal heart morphology 7 | 162
abnormal neural tube closure 7 | 46
abnormal spleen morphology 7 | 55
corneal opacity 7 | 32
decreased circulating alkaline... 7 | 46
decreased circulating insulin ... 7 | 76
decreased circulating serum al... 7 | 82
decreased circulating total pr... 7 | 49
decreased fasted circulating g... 7 | 65
decreased leukocyte cell numbe... 7 | 73
decreased lymphocyte cell numb... 7 | 83
enlarged spleen 7 | 41
increased bone mineral content 7 | 108
increased bone mineral density 7 | 72
increased fasted circulating g... 7 | 76
limb grasping 7 | 41
male infertility 7 | 123
short tibia 7 | 97
small superior vagus ganglion 7 | 74
abnormal bone mineralization 6 | 38
abnormal coat appearance 6 | 31
abnormal skin morphology 6 | 50
cataract 6 | 92
decreased circulating HDL chol... 6 | 68
decreased circulating aspartat... 6 | 34
decreased grip strength 6 | 116
decreased mean corpuscular hem... 6 | 50
decreased mean corpuscular vol... 6 | 79
impaired glucose tolerance 6 | 75
increased body weight 6 | 25
increased circulating HDL chol... 6 | 80
increased circulating calcium ... 6 | 34
increased circulating choleste... 6 | 66
increased circulating triglyce... 6 | 42
tremors 6 | 39
abnormal behavioral response t... 5 | 66
abnormal cornea morphology 5 | 31
abnormal craniofacial morpholo... 5 | 33
abnormal lens morphology 5 | 81
abnormal sleep behavior 5 | 70
decreased body length 5 | 101
decreased circulating alanine ... 5 | 47
decreased circulating amylase ... 5 | 28
decreased eosinophil cell numb... 5 | 24
improved glucose tolerance 5 | 79
increased blood urea nitrogen ... 5 | 48
increased grip strength 5 | 41
narrow eye opening 5 | 12
abnormal epididymis morphology 4 | 42
abnormal limb bud morphology 4 | 17
abnormal lung morphology 4 | 26
abnormal snout morphology 4 | 23
abnormal tooth morphology 4 | 24
abnormal vibrissa morphology 4 | 25
decreased circulating fructosa... 4 | 30
decreased hematocrit 4 | 46
decreased total retina thickne... 4 | 17
enlarged epididymis 4 | 31
increased circulating phosphat... 4 | 26
increased mean corpuscular hem... 4 | 96
pale yolk sac 4 | 25
persistence of hyaloid vascula... 4 | 33
thrombocytopenia 4 | 56

Disease

spina bifida 1,074 | 1,074
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 1,060 | 17,369
Endocrine System 1,060 | 18,159
Skin and soft tissues 1,060 | 17,230
Female tissues 1,056 | 17,400
Male tissues 1,052 | 17,142
Urinary Tract 1,051 | 16,678
Blood and immune system 1,046 | 16,909
Liver and Pancreas 1,046 | 16,750
Nervous System 1,033 | 16,725
Respiratory system 1,032 | 16,393
Cardiovascular System 990 | 15,192

Target Family

Non-IDG 647 | 12,091
Enzyme 219 | 4,145
Transcription Factor 92 | 1,400
Kinase 51 | 634
Transporter 20 | 473
Epigenetic 18 | 242
GPCR 11 | 408
Ion Channel 9 | 344
TF/Epigenetic 4 | 38
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability