Targets

Target Filters...

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Ephrin type-A receptor 6	EPHA6	Tchem	Kinase	-1.34848	21.8	266
Active regulator of SIRT1	RPS19BP1	Tbio	Non-IDG	-1.70998	49.5	84
Copine-5	CPNE5	Tbio	Non-IDG	-0.45967	3.10	91
5'-AMP-activated protein kinase subunit beta-1	PRKAB1	Tbio	Kinase	-1.52519	32.5	532
Guanine nucleotide-binding protein G(i) subunit alpha-1	GNAI1	Tbio	Non-IDG	-0.63224	3.23	220
Prostate stem cell antigen	PSCA	Tbio	Non-IDG	-2.40263	274.6	299
Podocalyxin-like protein 2	PODXL2	Tbio	Non-IDG	-0.62337	4.07	162
AP-4 complex subunit epsilon-1	AP4E1	Tdark	Non-IDG	-0.66901	5.48	24
Gap junction beta-4 protein	GJB4	Tbio	Non-IDG	-1.60100	40.2	125
Glycerophosphodiester phosphodiesterase domain-containing protein 5	GDPD5	Tbio	Enzyme	-1.19911	17.6	110

	Tbio	41 \| 11,651
	Tdark	8 \| 6,593
	Tchem	4 \| 1,388
	Tclin	2 \| 612

	Kinase: IDG Consortium (Target...	2 \| 125
	RFA-RM-18-021	2 \| 328

	abnormal spleen morphology	55 \| 55
	preweaning lethality, complete...	979 \| 979
	preweaning lethality, incomple...	499 \| 499
	abnormal behavior	298 \| 298
	embryonic lethality prior to t...	278 \| 278
	embryonic lethality prior to o...	239 \| 239
	abnormal embryo size	220 \| 220
	enlarged heart	210 \| 210
	decreased vertical activity	208 \| 208
	decreased total body fat amoun...	207 \| 207
	abnormal bone structure	187 \| 187
	increased lean body mass	172 \| 172
	abnormal heart morphology	162 \| 162
	decreased body weight	161 \| 161
	decreased bone mineral content	151 \| 151
	hyperactivity	148 \| 148
	decreased lean body mass	135 \| 135
	increased total body fat amoun...	134 \| 134
	hypoactivity	132 \| 132
	decreased bone mineral density	126 \| 126
	decreased circulating glucose ...	126 \| 126
	male infertility	123 \| 123
	increased circulating alkaline...	122 \| 122
	decreased grip strength	116 \| 116
	abnormal seminal vesicle morph...	114 \| 114
	increased startle reflex	112 \| 112
	increased bone mineral content	108 \| 108
	embryonic growth retardation	106 \| 106
	decreased body length	101 \| 101
	increased or absent threshold ...	101 \| 101
	short tibia	97 \| 97
	increased mean corpuscular hem...	96 \| 96
	decreased circulating choleste...	93 \| 93
	cataract	92 \| 92
	increased mean corpuscular vol...	92 \| 92
	prenatal lethality prior to he...	87 \| 87
	decreased lymphocyte cell numb...	83 \| 83
	decreased circulating serum al...	82 \| 82
	decreased prepulse inhibition	82 \| 82
	abnormal lens morphology	81 \| 81
	increased circulating HDL chol...	80 \| 80
	decreased circulating triglyce...	79 \| 79
	decreased mean corpuscular vol...	79 \| 79
	improved glucose tolerance	79 \| 79
	decreased circulating insulin ...	76 \| 76
	increased fasted circulating g...	76 \| 76
	decreased startle reflex	75 \| 75
	impaired glucose tolerance	75 \| 75
	small superior vagus ganglion	74 \| 74
	decreased leukocyte cell numbe...	73 \| 73
	increased bone mineral density	72 \| 72
	abnormal retina morphology	71 \| 71
	increased circulating sodium l...	71 \| 71
	abnormal sleep behavior	70 \| 70
	abnormal gait	69 \| 69
	abnormal eye morphology	68 \| 68
	decreased circulating HDL chol...	68 \| 68
	decreased hemoglobin content	68 \| 68
	abnormal behavioral response t...	66 \| 66
	increased circulating choleste...	66 \| 66
	abnormal kidney morphology	65 \| 65
	decreased fasted circulating g...	65 \| 65
	abnormal coat-hair pigmentatio...	64 \| 64
	increased monocyte cell number	63 \| 63
	decreased erythrocyte cell num...	62 \| 62
	increased heart weight	62 \| 62
	female infertility	60 \| 60
	edema	59 \| 59
	small testis	58 \| 58
	thrombocytopenia	56 \| 56
	decreased caudal vertebrae num...	53 \| 53
	hydrometra	53 \| 53
	decreased blood urea nitrogen ...	51 \| 51
	abnormal skin morphology	50 \| 50
	decreased mean corpuscular hem...	50 \| 50
	decreased circulating total pr...	49 \| 49
	increased blood urea nitrogen ...	48 \| 48
	decreased circulating alanine ...	47 \| 47
	increased leukocyte cell numbe...	47 \| 47
	abnormal neural tube closure	46 \| 46
	decreased circulating alkaline...	46 \| 46
	decreased hematocrit	46 \| 46
	increased hematocrit	46 \| 46
	increased neutrophil cell numb...	46 \| 46
	increased hemoglobin content	45 \| 45
	increased mean platelet volume	45 \| 45
	abnormal testis morphology	43 \| 43
	abnormal epididymis morphology	42 \| 42
	decreased neutrophil cell numb...	42 \| 42
	increased circulating triglyce...	42 \| 42
	decreased red blood cell distr...	41 \| 41
	enlarged spleen	41 \| 41
	increased circulating chloride...	41 \| 41
	increased grip strength	41 \| 41
	limb grasping	41 \| 41
	decreased circulating creatini...	39 \| 39
	increased erythrocyte cell num...	39 \| 39
	tremors	39 \| 39
	abnormal bone mineralization	38 \| 38
	prolonged QT interval	38 \| 38

	Carcinoma	32 \| 11,493
	ovarian cancer	28 \| 8,520
	psoriasis	25 \| 6,694
	osteosarcoma	23 \| 7,950
	medulloblastoma, large-cell	21 \| 6,241
	atypical teratoid / rhabdoid tumor	20 \| 5,112
	glioblastoma	19 \| 5,792
	group 3 medulloblastoma	17 \| 4,104
	lung cancer	16 \| 4,740
	Breast cancer	14 \| 3,578
	invasive ductal carcinoma	14 \| 2,951
	ependymoma	12 \| 4,679
	adult high grade glioma	11 \| 3,801
	intraductal papillary-mucinous neoplasm (IPMN)	11 \| 3,291
	intraductal papillary-mucinous adenoma (IPMA)	10 \| 2,955
	intraductal papillary-mucinous carcinoma (IPMC)	10 \| 2,989
	lung carcinoma	10 \| 2,843
	malignant mesothelioma	10 \| 3,232
	subependymal giant cell astrocytoma	10 \| 2,287
	interstitial cystitis	9 \| 2,312
	non-small cell lung cancer	9 \| 2,890
	pituitary cancer	9 \| 1,972
	primitive neuroectodermal tumor	9 \| 3,035
	cystic fibrosis	8 \| 1,696
	ductal carcinoma in situ	8 \| 1,745
	lung adenocarcinoma	8 \| 2,716
	oligodendroglioma	8 \| 2,850
	pancreatic cancer	8 \| 2,398
	breast carcinoma	7 \| 1,638
	spina bifida	7 \| 1,074
	Astrocytoma, Pilocytic	6 \| 3,081
	Cancer	6 \| 2,499
	Pick disease	6 \| 1,894
	adrenocortical carcinoma	6 \| 1,428
	astrocytic glioma	6 \| 2,597
	Prostatic Neoplasms	5 \| 495
	Rheumatoid arthritis	5 \| 1,191
	acute quadriplegic myopathy	5 \| 1,158
	tuberculosis	5 \| 2,010
	Autosomal recessive predisposition	4 \| 1,442
	Intellectual disability	4 \| 1,016
	Multiple myeloma	4 \| 1,332
	Schizophrenia	4 \| 1,160
	Stomach Neoplasms	4 \| 300
	acute myeloid leukemia	4 \| 783
	astrocytoma	4 \| 1,146
	colon cancer	4 \| 1,478
	diabetes mellitus	4 \| 1,728
	group 4 medulloblastoma	4 \| 1,855
	juvenile dermatomyositis	4 \| 1,187
	pancreatic ductal adenocarcinoma liver metastasis	4 \| 1,962
	primary pancreatic ductal adenocarcinoma	4 \| 1,109
	Cognitive delay	3 \| 608
	Disease Progression	3 \| 136
	Epilepsy	3 \| 792
	Global developmental delay	3 \| 608
	Kidney cancer	3 \| 2,613
	Liver cancer	3 \| 604
	Mental and motor retardation	3 \| 608
	active Crohn's disease	3 \| 922
	chronic rhinosinusitis	3 \| 512
	cutaneous lupus erythematosus	3 \| 1,057
	fibroadenoma	3 \| 559
	hepatocellular carcinoma	3 \| 547
	interstitial lung disease	3 \| 298
	posterior fossa group A ependymoma	3 \| 468
	ulcerative colitis	3 \| 1,819
	Arthritis, Rheumatoid	2 \| 174
	Asthma	2 \| 385
	Bladder Neoplasm	2 \| 112
	Breast Neoplasms	2 \| 445
	Bulbous nasal tip	2 \| 48
	Bulbous nose	2 \| 48
	Chronic Lymphocytic Leukemia	2 \| 262
	Crohn's disease	2 \| 321
	Dull intelligence	2 \| 645
	Endometriosis	2 \| 540
	Hypersensitivity reaction type II disease	2 \| 253
	Mammary Neoplasms	2 \| 425
	Mesothelioma, Malignant	2 \| 105
	Neoplasm Metastasis	2 \| 168
	Potato nose	2 \| 48
	Prenatal onset	2 \| 139
	Prostate cancer	2 \| 175
	Retrognathia	2 \| 54
	Seizures	2 \| 596
	Urinary Bladder Neoplasms	2 \| 114
	active ulcerative colitis	2 \| 764
	aldosterone-producing adenoma	2 \| 665
	atypical teratoid/rhabdoid tumor	2 \| 357
	chronic lymphosyte leukemia	2 \| 204
	gastric cancer	2 \| 459
	gastric carcinoma	2 \| 807
	hereditary spastic paraplegia	2 \| 318
	medulloblastoma	2 \| 720
	nephrosclerosis	2 \| 333
	pancreatic carcinoma	2 \| 562
	pediatric high grade glioma	2 \| 1,064
	progressive supranuclear palsy	2 \| 676
	sonic hedgehog group medulloblastoma	2 \| 467

	Endocrine System	55 \| 18,159
	Female tissues	54 \| 17,400
	Digestive Tract	53 \| 17,369
	Liver and Pancreas	53 \| 16,750
	Male tissues	53 \| 17,142
	Urinary Tract	53 \| 16,678
	Blood and immune system	52 \| 16,909
	Nervous System	52 \| 16,725
	Skin and soft tissues	52 \| 17,230
	Respiratory system	51 \| 16,393
	Cardiovascular System	47 \| 15,192

Development Level

Collection

IMPC Phenotype

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source

	Non-IDG	30 \| 12,091
	Enzyme	13 \| 4,145
	Kinase	6 \| 634
	Transcription Factor	3 \| 1,400
	Epigenetic	1 \| 242
	Ion Channel	1 \| 344
	Transporter	1 \| 473