Development Level

Tbio 10,255 | 11,445
Tdark 3,995 | 6,588
Tchem 1,462 | 1,598
Tclin 535 | 613

Collection

RFA-RM-18-021 257 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 71 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 952 | 979
preweaning lethality, incomple... 469 | 499
abnormal behavior 282 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 193 | 207
enlarged heart 193 | 210
decreased vertical activity 177 | 208
abnormal bone structure 170 | 187
increased lean body mass 160 | 172
decreased body weight 155 | 161
abnormal heart morphology 150 | 162
decreased bone mineral content 140 | 151
hyperactivity 137 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 125 | 134
hypoactivity 120 | 132
decreased circulating glucose ... 119 | 126
decreased bone mineral density 115 | 126
increased circulating alkaline... 112 | 122
decreased grip strength 106 | 116
increased startle reflex 104 | 112
embryonic growth retardation 102 | 106
abnormal seminal vesicle morph... 100 | 114
male infertility 100 | 123
increased bone mineral content 97 | 108
decreased body length 94 | 101
increased or absent threshold ... 92 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
increased mean corpuscular hem... 89 | 96
decreased circulating choleste... 88 | 93
cataract 86 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 78 | 83
decreased circulating serum al... 77 | 82
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 71 | 79
increased bone mineral density 71 | 72
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 71 | 76
decreased leukocyte cell numbe... 69 | 73
improved glucose tolerance 69 | 79
abnormal eye morphology 68 | 68
decreased circulating insulin ... 68 | 76
decreased startle reflex 68 | 75
small superior vagus ganglion 68 | 74
abnormal retina morphology 67 | 71
impaired glucose tolerance 66 | 75
abnormal gait 65 | 69
decreased circulating HDL chol... 65 | 68
increased circulating sodium l... 65 | 71
abnormal sleep behavior 64 | 70
abnormal coat-hair pigmentatio... 61 | 64
decreased fasted circulating g... 61 | 65
abnormal behavioral response t... 60 | 66
abnormal kidney morphology 60 | 65
decreased hemoglobin content 60 | 68
increased circulating choleste... 60 | 66
decreased erythrocyte cell num... 58 | 62
increased monocyte cell number 58 | 63
increased heart weight 57 | 62
edema 56 | 59
small testis 55 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
female infertility 52 | 60
abnormal spleen morphology 51 | 55
hydrometra 48 | 53
decreased circulating total pr... 47 | 49
abnormal skin morphology 46 | 50
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased leukocyte cell numbe... 44 | 47
increased neutrophil cell numb... 44 | 46
increased hematocrit 43 | 46
decreased hematocrit 42 | 46
abnormal testis morphology 41 | 43
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
abnormal cranium morphology 36 | 36
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39
limb grasping 36 | 41
tremors 36 | 39
increased grip strength 35 | 41

Disease

Carcinoma 9,875 | 11,493
ovarian cancer 8,167 | 8,520
osteosarcoma 7,526 | 7,950
medulloblastoma, large-cell 5,830 | 6,241
psoriasis 5,814 | 6,694
glioblastoma 5,518 | 5,792
atypical teratoid / rhabdoid tumor 4,838 | 5,112
lung cancer 4,494 | 4,740
ependymoma 4,400 | 4,679
group 3 medulloblastoma 3,883 | 4,104
adult high grade glioma 3,546 | 3,801
Breast cancer 3,394 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,206 | 3,291
malignant mesothelioma 3,122 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,922 | 2,989
Astrocytoma, Pilocytic 2,902 | 3,081
invasive ductal carcinoma 2,901 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,880 | 2,955
primitive neuroectodermal tumor 2,870 | 3,035
non-small cell lung cancer 2,786 | 2,890
oligodendroglioma 2,695 | 2,850
lung carcinoma 2,692 | 2,843
lung adenocarcinoma 2,586 | 2,716
astrocytic glioma 2,460 | 2,597
pancreatic cancer 2,306 | 2,398
Kidney cancer 2,300 | 2,613
Cancer 2,247 | 2,499
interstitial cystitis 2,222 | 2,312
subependymal giant cell astrocytoma 2,185 | 2,287
tuberculosis 1,949 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,896 | 1,962
pituitary cancer 1,854 | 1,972
Pick disease 1,830 | 1,894
group 4 medulloblastoma 1,780 | 1,855
ulcerative colitis 1,767 | 1,819
ductal carcinoma in situ 1,711 | 1,745
cystic fibrosis 1,616 | 1,696
breast carcinoma 1,590 | 1,638
colon cancer 1,445 | 1,478
adrenocortical carcinoma 1,404 | 1,428
diabetes mellitus 1,355 | 1,728
Multiple myeloma 1,311 | 1,332
Autosomal recessive predisposition 1,302 | 1,442
juvenile dermatomyositis 1,169 | 1,187
acute quadriplegic myopathy 1,132 | 1,158
astrocytoma 1,110 | 1,146
Rheumatoid arthritis 1,095 | 1,191
primary pancreatic ductal adenocarcinoma 1,089 | 1,109
spina bifida 1,029 | 1,074
pediatric high grade glioma 1,022 | 1,064
Schizophrenia 1,017 | 1,160
cutaneous lupus erythematosus 1,012 | 1,057
nasopharyngeal carcinoma 983 | 1,058
Intellectual disability 950 | 1,016
dermatomyositis 919 | 966
active Crohn's disease 899 | 922
Atopic dermatitis 868 | 952
non primary Sjogren syndrome sicca 829 | 891
acute myeloid leukemia 776 | 783
gastric carcinoma 774 | 807
Waldenstrons macroglobulinemia 759 | 765
Epilepsy 735 | 792
active ulcerative colitis 735 | 764
Liver Cirrhosis, Experimental 733 | 769
primary Sjogren syndrome 719 | 735
esophageal adenocarcinoma 705 | 737
medulloblastoma 679 | 720
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 649 | 665
Alzheimer's disease 604 | 658
Obesity 604 | 678
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Duchenne muscular dystrophy 580 | 601
Bipolar Disorder 577 | 666
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Mental and motor retardation 573 | 608
Melanoma 571 | 711
Seizures 559 | 596
pancreatic carcinoma 553 | 562
fibroadenoma 546 | 559
Muscle hypotonia 542 | 571
hepatocellular carcinoma 538 | 547
Liver cancer 510 | 604
Endometriosis 505 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Short stature 498 | 531
Down syndrome 478 | 499
Prostatic Neoplasms 470 | 495
chronic rhinosinusitis 464 | 512
Multiple Sclerosis 463 | 540
mucosa-associated lymphoid tissue lymphoma 459 | 484
gastric cancer 453 | 459
posterior fossa group A ependymoma 450 | 468
sonic hedgehog group medulloblastoma 443 | 467
Amyotrophic lateral sclerosis 435 | 451

Tissue

Digestive Tract 16,247 | 17,369
Endocrine System 16,183 | 18,159
Female tissues 16,092 | 17,400
Skin and soft tissues 16,068 | 17,230
Blood and immune system 16,026 | 16,909
Male tissues 15,977 | 17,142
Liver and Pancreas 15,922 | 16,750
Urinary Tract 15,871 | 16,678
Respiratory system 15,743 | 16,393
Nervous System 15,737 | 16,725
Cardiovascular System 14,806 | 15,192

Target Family

Non-IDG 9,447 | 12,091
Enzyme 3,739 | 4,145
Transcription Factor 1,194 | 1,400
Kinase 597 | 634
Transporter 389 | 473
GPCR 283 | 408
Ion Channel 270 | 344
Epigenetic 231 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 35 | 38
oGPCR 18 | 421

HPA RNA Tissue

appendix 16,247 | 16,247
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39