Development Level

Tbio 106 | 11,651
Tchem 32 | 1,388
Tclin 16 | 612
Tdark 10 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal heart morphology 3 | 162
decreased vertical activity 3 | 208
enlarged heart 3 | 210
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased lymphocyte cell numb... 2 | 83
embryonic lethality prior to t... 2 | 278
increased erythrocyte cell num... 2 | 39
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal kidney morphology 1 | 65
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
cyanosis 1 | 7
decreased IgG3 level 1 | 1
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2
small testis 1 | 58

Disease

ovarian cancer 93 | 8,520
Carcinoma 83 | 11,493
lung cancer 73 | 4,740
osteosarcoma 68 | 7,950
psoriasis 65 | 6,694
glioblastoma 56 | 5,792
Cancer 46 | 2,499
lung carcinoma 41 | 2,843
Rheumatoid arthritis 38 | 1,191
medulloblastoma, large-cell 38 | 6,241
Multiple myeloma 36 | 1,332
interstitial cystitis 36 | 2,312
invasive ductal carcinoma 32 | 2,951
atypical teratoid / rhabdoid tumor 31 | 5,112
diabetes mellitus 31 | 1,728
malignant mesothelioma 30 | 3,232
Breast cancer 29 | 3,578
cutaneous lupus erythematosus 29 | 1,057
subependymal giant cell astrocytoma 29 | 2,287
tuberculosis 28 | 2,010
ependymoma 27 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
adult high grade glioma 26 | 3,801
non-small cell lung cancer 26 | 2,890
sarcoidosis 26 | 370
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
Astrocytoma, Pilocytic 23 | 3,081
Waldenstrons macroglobulinemia 23 | 765
primary Sjogren syndrome 23 | 735
ulcerative colitis 23 | 1,819
dermatomyositis 22 | 966
oligodendroglioma 22 | 2,850
group 3 medulloblastoma 21 | 4,104
juvenile dermatomyositis 21 | 1,187
pancreatic cancer 21 | 2,398
Kidney cancer 19 | 2,613
Narcolepsy 19 | 72
astrocytic glioma 19 | 2,597
astrocytoma 19 | 1,146
Autosomal recessive predisposition 18 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
HIV Infections 17 | 102
Schizophrenia 17 | 1,160
breast carcinoma 17 | 1,638
primitive neuroectodermal tumor 17 | 3,035
Berylliosis 16 | 28
Pick disease 16 | 1,894
follicular lymphoma 16 | 20
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Hypersensitivity reaction type II disease 15 | 253
Immunologic Deficiency Syndromes 15 | 113
Systemic lupus erythematosus 15 | 194
non primary Sjogren syndrome sicca 15 | 891
Multiple Sclerosis 14 | 540
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
cystic fibrosis 14 | 1,696
group 4 medulloblastoma 14 | 1,855
lung adenocarcinoma 14 | 2,716
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
limited scleroderma 13 | 19
Arthritis, Rheumatoid 12 | 174
Asthma 12 | 385
Bipolar Disorder 11 | 666
Crohn's disease 11 | 321
Failure to gain weight 11 | 365
Liver Cirrhosis, Experimental 11 | 769
Pediatric failure to thrive 11 | 365
Splenomegaly 11 | 190
active Crohn's disease 11 | 922
pituitary cancer 11 | 1,972
primary pancreatic ductal adenocarcinoma 11 | 1,109
Arthritis 10 | 290
Autoimmune Diseases 10 | 67
Duchenne muscular dystrophy 10 | 601
Type 1 diabetes mellitus 10 | 109
acute myeloid leukemia 10 | 783
Breast Neoplasms 9 | 445
Diarrhea 9 | 253
Epilepsy 9 | 792
Infantile onset 9 | 238
Juvenile rheumatoid arthritis 9 | 111
Lymphadenopathy 9 | 62
Mammary Neoplasms 9 | 425
Recurrent respiratory infections 9 | 141
Seizures 9 | 596
adrenocortical carcinoma 9 | 1,428
ductal carcinoma in situ 9 | 1,745
esophageal adenocarcinoma 9 | 737
Alzheimer's disease 8 | 658
Anemia 8 | 365
Hepatitis B 8 | 108
Intellectual disability 8 | 1,016
Proteinuria 8 | 144
active ulcerative colitis 8 | 764
colon cancer 8 | 1,478
hepatocellular carcinoma 8 | 547
pancreatic carcinoma 8 | 562

Tissue

Endocrine System 141 | 18,159
Respiratory system 141 | 16,393
Blood and immune system 140 | 16,909
Digestive Tract 140 | 17,369
Female tissues 140 | 17,400
Liver and Pancreas 140 | 16,750
Male tissues 140 | 17,142
Skin and soft tissues 140 | 17,230
Urinary Tract 140 | 16,678
Cardiovascular System 138 | 15,192
Nervous System 135 | 16,725

Target Family

Non-IDG 79 | 12,091
Enzyme 56 | 4,145
Kinase 24 | 634
Transcription Factor 4 | 1,400
Ion Channel 1 | 344

GO Process

T cell receptor signaling path... 164 | 164
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
F-box/WD repeat-containing protein 11 FBXW11 Tbio Non-IDG -0.75887 5.88 183
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216
Stomatin-like protein 2, mitochondrial STOML2 Tbio Non-IDG -0.84987 9.04 154