Development Level

Tbio 159 | 11,445
Tdark 35 | 6,588
Tchem 8 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 18 | 499
decreased bone mineral content 10 | 151
preweaning lethality, complete... 10 | 979
abnormal behavior 9 | 298
abnormal bone structure 9 | 187
decreased bone mineral density 8 | 126
embryonic lethality prior to t... 7 | 278
male infertility 7 | 123
decreased body length 5 | 101
enlarged heart 5 | 210
female infertility 5 | 60
short tibia 5 | 97
abnormal embryo size 4 | 220
decreased body weight 4 | 161
decreased circulating chloride... 4 | 30
decreased circulating triglyce... 4 | 79
decreased lean body mass 4 | 135
decreased startle reflex 4 | 75
increased fasted circulating g... 4 | 76
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
decreased leukocyte cell numbe... 3 | 73
decreased prepulse inhibition 3 | 82
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
increased circulating calcium ... 3 | 34
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
increased total body fat amoun... 3 | 134
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal forebrain development 2 | 20
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased circulating alkaline... 2 | 46
decreased circulating fructosa... 2 | 30
decreased circulating insulin ... 2 | 76
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
enlarged kidney 2 | 14
enlarged spleen 2 | 41
increased body length 2 | 32
increased heart weight 2 | 62
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
narrow eye opening 2 | 12
pale yolk sac 2 | 25
small liver 2 | 8
tremors 2 | 39
trunk curl 2 | 16
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal cranium morphology 1 | 36
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased circulating amylase ... 1 | 28
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
iris synechia 1 | 3
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small thymus 1 | 16
thick skin 1 | 4
thin ventricular wall 1 | 24

Disease

ovarian cancer 133 | 8,520
Carcinoma 126 | 11,493
osteosarcoma 105 | 7,950
medulloblastoma, large-cell 83 | 6,241
psoriasis 71 | 6,694
glioblastoma 69 | 5,792
atypical teratoid / rhabdoid tumor 62 | 5,112
lung cancer 54 | 4,740
ependymoma 48 | 4,679
adult high grade glioma 44 | 3,801
group 3 medulloblastoma 43 | 4,104
Breast cancer 40 | 3,578
Kidney cancer 39 | 2,613
astrocytic glioma 37 | 2,597
primitive neuroectodermal tumor 37 | 3,035
oligodendroglioma 35 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Cancer 31 | 2,499
pancreatic cancer 31 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
Pick disease 28 | 1,894
group 4 medulloblastoma 28 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 27 | 2,955
malignant mesothelioma 27 | 3,232
Astrocytoma, Pilocytic 26 | 3,081
Multiple myeloma 26 | 1,332
subependymal giant cell astrocytoma 26 | 2,287
juvenile dermatomyositis 24 | 1,187
invasive ductal carcinoma 23 | 2,951
spina bifida 23 | 1,074
lung adenocarcinoma 21 | 2,716
medulloblastoma 20 | 720
non-small cell lung cancer 20 | 2,890
Rheumatoid arthritis 19 | 1,191
Intellectual disability 18 | 1,016
breast carcinoma 18 | 1,638
lung carcinoma 17 | 2,843
acute quadriplegic myopathy 16 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
adrenocortical carcinoma 15 | 1,428
tuberculosis 15 | 2,010
Autosomal recessive predisposition 14 | 1,442
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
ulcerative colitis 14 | 1,819
acute myeloid leukemia 13 | 783
pituitary cancer 13 | 1,972
cystic fibrosis 12 | 1,696
ductal carcinoma in situ 12 | 1,745
interstitial cystitis 12 | 2,312
tuberculosis and treatment for 6 months 12 | 409
primary pancreatic ductal adenocarcinoma 11 | 1,109
dermatomyositis 10 | 966
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
Endometriosis 9 | 540
Liver cancer 9 | 604
Short stature 9 | 531
astrocytoma 9 | 1,146
diabetes mellitus 9 | 1,728
esophageal adenocarcinoma 9 | 737
hepatocellular carcinoma 9 | 547
primary Sjogren syndrome 9 | 735
Atopic dermatitis 8 | 952
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Muscle hypotonia 8 | 571
Thrombocytopenia 8 | 197
active Crohn's disease 8 | 922
Acquired scoliosis 7 | 281
Amyotrophic lateral sclerosis 7 | 451
Curvature of spine 7 | 282
Parkinson's disease 7 | 392
colon cancer 7 | 1,478
hereditary spastic paraplegia 7 | 318
Anemia 6 | 365
Autistic Disorder 6 | 364
Big calvaria 6 | 147
Decreased platelet count 6 | 111
Epilepsy 6 | 792
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Nystagmus 6 | 317
cutaneous lupus erythematosus 6 | 1,057
progressive supranuclear palsy 6 | 676
Alzheimer's disease 5 | 658
Attention deficit hyperactivity disorder 5 | 278
Depressed nasal bridge 5 | 195
Hepatomegaly 5 | 285
Seizures 5 | 596
Small head 5 | 374
Strabismus 5 | 270
aldosterone-producing adenoma 5 | 665
gastric cancer 5 | 459
sonic hedgehog group medulloblastoma 5 | 467

Tissue

Endocrine System 201 | 18,159
Blood and immune system 198 | 16,909
Female tissues 198 | 17,400
Digestive Tract 197 | 17,369
Male tissues 197 | 17,142
Liver and Pancreas 196 | 16,750
Nervous System 196 | 16,725
Skin and soft tissues 195 | 17,230
Urinary Tract 195 | 16,678
Respiratory system 194 | 16,393
Cardiovascular System 191 | 15,192

Target Family

Enzyme 131 | 4,145
Non-IDG 65 | 12,091
Epigenetic 5 | 242
Transcription Factor 1 | 1,400

GO Function

ubiquitin protein ligase activ... 202 | 202
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
LON peptidase N-terminal domain and RING finger protein 3 LONRF3 Tdark Enzyme 0.00000 104
E3 ubiquitin-protein ligase AMFR AMFR Tbio Enzyme -2.46909 292.8 203
E3 ubiquitin-protein ligase Praja-2 PJA2 Tbio Enzyme -0.64427 3.70 175
E3 ubiquitin-protein ligase UHRF2 UHRF2 Tbio Epigenetic -1.57250 40.4 202
RING finger protein 222 RNF222 Tdark Non-IDG 0.00000 4
E3 ubiquitin-protein ligase RNF139 RNF139 Tbio Enzyme -1.17169 16.6 133
E3 ubiquitin-protein ligase RNF138 RNF138 Tbio Transcription Factor -1.08996 12.5 148