Development Level

Tbio 434 | 11,178
Tdark 136 | 6,569
Tchem 95 | 1,885
Tclin 74 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 75 | 979
embryonic lethality prior to o... 24 | 239
embryonic lethality prior to t... 22 | 278
abnormal behavior 16 | 298
preweaning lethality, incomple... 14 | 499
abnormal embryo size 12 | 220
decreased total body fat amoun... 11 | 207
decreased vertical activity 11 | 208
increased lean body mass 11 | 172
decreased body weight 10 | 161
decreased bone mineral content 10 | 151
embryonic growth retardation 10 | 106
hyperactivity 10 | 148
increased total body fat amoun... 10 | 134
abnormal bone structure 8 | 187
decreased lean body mass 8 | 135
enlarged heart 8 | 210
abnormal lens morphology 7 | 81
cataract 7 | 92
hypoactivity 7 | 132
prenatal lethality prior to he... 7 | 87
decreased circulating glucose ... 6 | 126
decreased mean corpuscular vol... 6 | 79
pallor 6 | 34
abnormal heart morphology 5 | 162
abnormal neural tube closure 5 | 46
decreased body length 5 | 101
decreased circulating LDL chol... 5 | 38
increased circulating phosphat... 5 | 26
increased circulating sodium l... 5 | 71
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 96
increased startle reflex 5 | 112
abnormal skin morphology 4 | 50
abnormal sleep behavior 4 | 70
decreased circulating HDL chol... 4 | 68
decreased circulating choleste... 4 | 93
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
decreased total retina thickne... 4 | 17
increased circulating HDL chol... 4 | 80
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal embryo turning 3 | 31
abnormal gait 3 | 69
abnormal midbrain development 3 | 20
abnormal seminal vesicle morph... 3 | 114
decreased bone mineral density 3 | 126
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating creatini... 3 | 39
decreased grip strength 3 | 116
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 50
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased circulating bilirubi... 3 | 16
increased circulating calcium ... 3 | 34
increased circulating choleste... 3 | 66
increased fasted circulating g... 3 | 76
increased mean corpuscular vol... 3 | 92
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
pale yolk sac 3 | 25
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
abnormal heart left ventricle ... 2 | 16
abnormal limb bud morphology 2 | 17
abnormal lung morphology 2 | 26
abnormal neural tube morpholog... 2 | 12
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
abnormal vocalization 2 | 21
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased food intake 2 | 13
decreased hemoglobin content 2 | 68
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
impaired righting response 2 | 26
increased anti-nuclear antigen... 2 | 19
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
male infertility 2 | 123
prenatal lethality 2 | 28
small testis 2 | 58

Disease

ovarian cancer 400 | 8,297
osteosarcoma 310 | 7,766
Carcinoma 305 | 11,192
lung cancer 231 | 4,607
psoriasis 221 | 6,514
medulloblastoma, large-cell 220 | 6,086
glioblastoma 201 | 5,635
atypical teratoid / rhabdoid tumor 175 | 4,971
ependymoma 162 | 4,559
pancreatic ductal adenocarcinoma liver metastasis 157 | 1,911
Multiple myeloma 134 | 1,296
adult high grade glioma 129 | 3,701
Breast cancer 127 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 127 | 3,204
Cancer 123 | 2,388
malignant mesothelioma 115 | 3,135
group 3 medulloblastoma 114 | 4,002
astrocytic glioma 112 | 2,530
Autosomal recessive predisposition 108 | 1,407
invasive ductal carcinoma 105 | 2,867
non-small cell lung cancer 103 | 2,799
diabetes mellitus 97 | 1,683
lung adenocarcinoma 94 | 2,627
oligodendroglioma 94 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 91 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 84 | 2,872
Astrocytoma, Pilocytic 83 | 3,006
primitive neuroectodermal tumor 82 | 2,957
lung carcinoma 80 | 2,755
tuberculosis 79 | 1,963
group 4 medulloblastoma 76 | 1,806
Schizophrenia 75 | 1,136
Pick disease 71 | 1,856
pancreatic cancer 69 | 2,322
Epilepsy 68 | 775
ulcerative colitis 68 | 1,765
breast carcinoma 65 | 1,589
Obesity 64 | 655
Alzheimer's disease 63 | 640
subependymal giant cell astrocytoma 63 | 2,230
non primary Sjogren syndrome sicca 62 | 861
Muscle hypotonia 61 | 562
Seizures 61 | 584
Cognitive delay 59 | 596
Global developmental delay 59 | 596
Mental and motor retardation 59 | 596
ductal carcinoma in situ 59 | 1,686
Cerebellar Ataxia 56 | 302
acute myeloid leukemia 55 | 760
Leigh disease 54 | 100
Waldenstrons macroglobulinemia 54 | 742
Neurodegenerative disease 53 | 402
Diabetes mellitus type 2 52 | 69
Intellectual disability 52 | 998
Rheumatoid arthritis 52 | 1,156
Treatment Refractory Type 2 Diabetes Mellitus 51 | 53
pituitary cancer 51 | 1,915
Optic Atrophy 50 | 239
Parkinson's disease 50 | 378
astrocytoma 50 | 1,113
colon cancer 49 | 1,428
Failure to gain weight 48 | 359
Pediatric failure to thrive 48 | 359
adrenocortical carcinoma 47 | 1,385
cystic fibrosis 47 | 1,629
Acidosis, Lactic 46 | 97
Lactic acidemia 46 | 95
Toxic encephalopathy 46 | 139
Dystonia 45 | 163
interstitial cystitis 45 | 2,237
Blepharoptosis 44 | 229
Breast Neoplasms 43 | 423
Mammary Neoplasms 43 | 403
dermatomyositis 43 | 941
Dull intelligence 40 | 634
Low intelligence 40 | 634
Mental Retardation 40 | 634
Mental deficiency 40 | 634
Poor school performance 40 | 634
acute quadriplegic myopathy 40 | 1,133
Bipolar Disorder 39 | 646
Hyperreflexia 39 | 208
Liver Cirrhosis, Experimental 39 | 733
Mitochondrial complex I deficiency 39 | 46
Nystagmus 39 | 309
Sensorineural Hearing Loss (disorder) 38 | 281
Anemia 37 | 353
Muscle Weakness 37 | 168
Neuropathy 37 | 254
Vascular disease 37 | 294
aldosterone-producing adenoma 37 | 646
Hypertrophic Cardiomyopathy 36 | 115
Stomach Neoplasms 36 | 287
pediatric high grade glioma 36 | 1,035
Kidney disease 35 | 411
Depressive disorder 34 | 401
Heart failure 34 | 157
Increased serum lactate 34 | 60
Kidney cancer 34 | 2,548
juvenile dermatomyositis 33 | 1,147

Tissue

Endocrine System 728 | 18,159
Digestive Tract 722 | 17,369
Male tissues 718 | 17,142
Female tissues 717 | 17,400
Skin and soft tissues 717 | 17,230
Blood and immune system 716 | 16,909
Liver and Pancreas 715 | 16,750
Nervous System 714 | 16,725
Urinary Tract 713 | 16,678
Respiratory system 706 | 16,393
Cardiovascular System 702 | 15,192

Target Family

Non-IDG 340 | 12,091
Enzyme 290 | 4,145
Transporter 63 | 473
Kinase 28 | 634
Transcription Factor 7 | 1,400
Epigenetic 5 | 242
GPCR 3 | 408
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

Compartment GO Term

Mitochondrial envelope 739 | 739
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Integral component of plasma m... 1,647 | 1,647
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative cytochrome b-c1 complex subunit Rieske-like protein 1 UQCRFS1P1 Tdark Non-IDG -2.12377 231.9 0
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
39S ribosomal protein L27, mitochondrial MRPL27 Tdark Non-IDG 0.60 0.05 48
Heat shock 70 kDa protein 4 HSPA4 Tbio Non-IDG -3.92672 8635.1 432
Mitochondria-eating protein SPATA18 Tbio Non-IDG -0.96526 11.0 92
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like BNIP3L Tbio Non-IDG -2.20837 153.7 355
39S ribosomal protein L36, mitochondrial MRPL36 Tdark Non-IDG -1.19524 14.7 33
2,4-dienoyl-CoA reductase, mitochondrial DECR1 Tbio Enzyme -4.22091 15887.9 151