Development Level

Tbio 835 | 11,178
Tchem 380 | 1,885
Tclin 279 | 612
Tdark 153 | 6,569

Collection

GPCR: IDG Consortium (Targets) 47 | 126
Ion Channel: IDG Consortium (T... 47 | 99
GPCR: IDG Consortium (Complete... 16 | 25
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 61 | 979
preweaning lethality, incomple... 49 | 499
abnormal behavior 35 | 298
decreased vertical activity 25 | 208
enlarged heart 25 | 210
decreased total body fat amoun... 22 | 207
embryonic lethality prior to t... 20 | 278
hyperactivity 19 | 148
increased lean body mass 18 | 172
abnormal bone structure 17 | 187
abnormal heart morphology 17 | 162
abnormal embryo size 16 | 220
embryonic lethality prior to o... 16 | 239
decreased body weight 15 | 161
abnormal seminal vesicle morph... 13 | 114
impaired glucose tolerance 13 | 75
increased mean corpuscular vol... 13 | 92
increased total body fat amoun... 13 | 134
small superior vagus ganglion 13 | 74
decreased bone mineral content 12 | 151
decreased grip strength 12 | 116
increased circulating alkaline... 12 | 122
increased startle reflex 12 | 112
decreased circulating insulin ... 11 | 76
decreased lymphocyte cell numb... 11 | 83
decreased prepulse inhibition 11 | 82
increased bone mineral content 11 | 108
increased circulating sodium l... 11 | 71
abnormal epididymis morphology 10 | 42
abnormal gait 10 | 69
hypoactivity 10 | 132
improved glucose tolerance 10 | 79
tremors 10 | 39
decreased fasted circulating g... 9 | 65
increased leukocyte cell numbe... 9 | 47
limb grasping 9 | 41
abnormal kidney morphology 8 | 65
decreased bone mineral density 8 | 126
decreased circulating HDL chol... 8 | 68
decreased circulating alkaline... 8 | 46
decreased circulating choleste... 8 | 93
decreased erythrocyte cell num... 8 | 62
decreased lean body mass 8 | 135
decreased mean corpuscular vol... 8 | 79
increased circulating choleste... 8 | 66
increased mean corpuscular hem... 8 | 96
increased monocyte cell number 8 | 63
abnormal eye morphology 7 | 68
abnormal retina morphology 7 | 71
abnormal sleep behavior 7 | 70
cardiovascular system phenotyp... 7 | 36
cataract 7 | 92
decreased circulating glucose ... 7 | 126
enlarged epididymis 7 | 31
increased circulating HDL chol... 7 | 80
increased circulating chloride... 7 | 41
increased neutrophil cell numb... 7 | 46
abnormal behavioral response t... 6 | 66
abnormal lens morphology 6 | 81
abnormal skin morphology 6 | 50
decreased body length 6 | 101
decreased circulating LDL chol... 6 | 38
decreased circulating creatini... 6 | 39
decreased circulating triglyce... 6 | 79
decreased eosinophil cell numb... 6 | 24
edema 6 | 59
enlarged spleen 6 | 41
hydrometra 6 | 53
increased circulating triglyce... 6 | 42
increased erythrocyte cell num... 6 | 39
male infertility 6 | 123
prolonged QT interval 6 | 38
prolonged ST segment 6 | 36
short tibia 6 | 97
thrombocytopenia 6 | 56
abnormal testis morphology 5 | 43
decreased circulating serum al... 5 | 82
decreased heart weight 5 | 27
decreased leukocyte cell numbe... 5 | 73
decreased mean corpuscular hem... 5 | 50
embryonic growth retardation 5 | 106
increased circulating amylase ... 5 | 25
increased circulating creatini... 5 | 38
increased fasted circulating g... 5 | 76
increased grip strength 5 | 41
increased hematocrit 5 | 46
increased lymphocyte cell numb... 5 | 32
increased mean platelet volume 5 | 45
pale yolk sac 5 | 25
pallor 5 | 34
small testis 5 | 58
abnormal bone mineralization 4 | 38
abnormal lung morphology 4 | 26
abnormal vibrissa morphology 4 | 25
absent vibrissae 4 | 12
decreased circulating calcium ... 4 | 36
decreased hematocrit 4 | 46
decreased hemoglobin content 4 | 68
increased circulating calcium ... 4 | 34
increased or absent threshold ... 4 | 101

Disease

Carcinoma 1,214 | 11,192
psoriasis 745 | 6,514
osteosarcoma 682 | 7,766
ovarian cancer 673 | 8,297
glioblastoma 611 | 5,635
medulloblastoma, large-cell 575 | 6,086
lung cancer 546 | 4,607
atypical teratoid / rhabdoid tumor 499 | 4,971
Cancer 498 | 2,388
ependymoma 476 | 4,559
lung carcinoma 455 | 2,755
adult high grade glioma 427 | 3,701
Astrocytoma, Pilocytic 401 | 3,006
non-small cell lung cancer 371 | 2,799
malignant mesothelioma 366 | 3,135
interstitial cystitis 361 | 2,237
Kidney cancer 357 | 2,548
Breast cancer 350 | 3,469
group 3 medulloblastoma 350 | 4,002
lung adenocarcinoma 341 | 2,627
invasive ductal carcinoma 339 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 330 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 330 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 325 | 2,902
pancreatic cancer 310 | 2,322
oligodendroglioma 298 | 2,768
diabetes mellitus 288 | 1,683
tuberculosis 281 | 1,963
primitive neuroectodermal tumor 278 | 2,957
Schizophrenia 268 | 1,136
ulcerative colitis 267 | 1,765
astrocytic glioma 260 | 2,530
subependymal giant cell astrocytoma 260 | 2,230
pituitary cancer 244 | 1,915
cystic fibrosis 227 | 1,629
Autosomal recessive predisposition 220 | 1,407
ductal carcinoma in situ 211 | 1,686
cutaneous lupus erythematosus 203 | 1,016
colon cancer 195 | 1,428
Rheumatoid arthritis 193 | 1,156
pancreatic ductal adenocarcinoma liver metastasis 187 | 1,911
breast carcinoma 179 | 1,589
Multiple Sclerosis 160 | 527
Pick disease 159 | 1,856
Kidney disease 157 | 411
group 4 medulloblastoma 157 | 1,806
Bipolar Disorder 153 | 646
Epilepsy 150 | 775
Arthritis 143 | 276
adrenocortical carcinoma 143 | 1,385
Hypersensitivity reaction type II disease 142 | 245
Melanoma 138 | 689
Hypertension 135 | 372
Liver Cirrhosis, Experimental 134 | 733
Obesity 134 | 655
primary pancreatic ductal adenocarcinoma 130 | 1,071
Depressive disorder 118 | 401
Asthma 117 | 370
dermatomyositis 117 | 941
astrocytoma 113 | 1,113
Alzheimer's disease 112 | 640
active Crohn's disease 111 | 882
Anemia 109 | 353
pediatric high grade glioma 108 | 1,035
Intellectual disability 107 | 998
nasopharyngeal carcinoma 106 | 1,024
gastric carcinoma 105 | 781
primary Sjogren syndrome 102 | 710
Mental Depression 101 | 325
Skin cancer 101 | 451
mucosa-associated lymphoid tissue lymphoma 101 | 473
Liver disease 100 | 227
active ulcerative colitis 99 | 736
Seizures 98 | 584
Alcoholic Intoxication, Chronic 96 | 283
Atherosclerosis 94 | 276
Atopic dermatitis 94 | 915
esophageal adenocarcinoma 94 | 696
Liver cancer 92 | 589
juvenile dermatomyositis 92 | 1,147
Acquired immunodeficiency syndrome 90 | 192
Autistic Disorder 89 | 358
Coronary artery disease 89 | 253
Heart disease 88 | 288
Hypertensive disease 86 | 278
spina bifida 85 | 1,053
Dermatitis 83 | 154
Down syndrome 83 | 480
Duchenne muscular dystrophy 83 | 587
Major Depressive Disorder 83 | 293
Vascular disease 83 | 294
acute quadriplegic myopathy 83 | 1,133
Prostatic Neoplasms 81 | 472
Endometriosis 80 | 521
Human immunodeficiency virus infectious disease 80 | 136
Cerebrovascular disease 79 | 223
Parkinson's disease 79 | 378
aldosterone-producing adenoma 79 | 646
Ankylosing spondylitis 78 | 134
Breast Neoplasms 78 | 423

Tissue

Endocrine System 1,523 | 18,159
Digestive Tract 1,474 | 17,369
Female tissues 1,457 | 17,400
Nervous System 1,448 | 16,725
Skin and soft tissues 1,446 | 17,230
Male tissues 1,441 | 17,142
Liver and Pancreas 1,421 | 16,750
Urinary Tract 1,419 | 16,678
Blood and immune system 1,416 | 16,909
Respiratory system 1,362 | 16,393
Cardiovascular System 1,225 | 15,192

Target Family

Non-IDG 736 | 12,091
GPCR 258 | 408
Transporter 223 | 473
Ion Channel 217 | 344
Enzyme 118 | 4,145
Kinase 77 | 634
Transcription Factor 9 | 1,400
oGPCR 9 | 421

Compartment GO Term

Integral component of plasma m... 1,647 | 1,647
cellular_component 17,863 | 17,863
Cell 15,779 | 15,779
Cell part 15,778 | 15,778
Intracellular 13,764 | 13,764
Intracellular part 13,630 | 13,630
Organelle 11,921 | 11,921
Intracellular organelle 11,712 | 11,712
membrane-bounded organelle 10,823 | 10,823
Cytoplasm 10,720 | 10,720
Intracellular membrane-bounded... 10,057 | 10,057
Cytoplasmic part 9,029 | 9,029
Organelle part 8,755 | 8,755
Intracellular organelle part 8,566 | 8,566
Membrane 8,335 | 8,335
Nucleus 7,336 | 7,336
Cytosol 6,551 | 6,551
Membrane part 6,403 | 6,403
Plasma membrane 5,682 | 5,682
Macromolecular complex 5,345 | 5,345
Intrinsic component of membran... 5,320 | 5,320
Cell periphery 5,248 | 5,248
Integral component of membrane 5,197 | 5,197
Nucleoplasm 4,931 | 4,931
Intracellular organelle lumen 4,923 | 4,923
Organelle lumen 4,923 | 4,923
membrane-enclosed lumen 4,923 | 4,923
Nuclear part 4,169 | 4,169
Endomembrane system 4,108 | 4,108
Intracellular non-membrane-bou... 3,917 | 3,917
non-membrane-bounded organelle 3,917 | 3,917
Nuclear lumen 3,851 | 3,851
Protein complex 3,565 | 3,565
Organelle membrane 2,798 | 2,798
Extracellular region 2,600 | 2,600
Plasma membrane part 2,531 | 2,531
Vesicle 2,280 | 2,280
Cytoplasmic vesicle 2,158 | 2,158
Intracellular vesicle 2,157 | 2,157
Cytoskeleton 2,084 | 2,084
Bounding membrane of organelle 1,924 | 1,924
Endoplasmic reticulum 1,922 | 1,922
Golgi apparatus 1,884 | 1,884
Intrinsic component of plasma ... 1,701 | 1,701
Cytoskeletal part 1,613 | 1,613
Catalytic complex 1,592 | 1,592
Vesicles 1,566 | 1,566
Mitochondrion 1,557 | 1,557
Extracellular region part 1,533 | 1,533
Cell projection 1,524 | 1,524
Whole membrane 1,521 | 1,521
Cytoplasmic vesicle part 1,468 | 1,468
Endoplasmic reticulum part 1,315 | 1,315
GO:0031975 1,139 | 1,139
Organelle envelope 1,131 | 1,131
Microtubule cytoskeleton 1,127 | 1,127
Nucleoplasm part 1,100 | 1,100
Nuclear outer membrane-endopla... 1,094 | 1,094
Endoplasmic reticulum membrane 1,076 | 1,076
Extracellular space 1,059 | 1,059
Mitochondrial part 1,027 | 1,027
Chromosome 1,020 | 1,020
Mitochondria 985 | 985
Neuron part 958 | 958
Supramolecular polymer 950 | 950
Cell junction 949 | 949
Supramolecular complex 949 | 949
Supramolecular fiber 942 | 942
Secretory vesicle 930 | 930
Golgi apparatus part 923 | 923
Nucleoli 923 | 923
Nucleolus 916 | 916
Endosome 915 | 915
Chromosomal part 872 | 872
GO:0098796 868 | 868
Ribonucleoprotein complex 845 | 845
Cell projection part 838 | 838
Transferase complex 837 | 837
Intracellular ribonucleoprotei... 830 | 830
Plasma membrane region 826 | 826
Secretory granule 810 | 810
Cell surface 805 | 805
Vesicle membrane 786 | 786
Cytoplasmic vesicle membrane 780 | 780
Polymeric cytoskeletal fiber 753 | 753
Mitochondrial envelope 739 | 739
Golgi membrane 715 | 715
Microtubule organizing center 712 | 712
Nuclear body 708 | 708
Vacuole 708 | 708
Neuron projection 701 | 701
Mitochondrial membrane 689 | 689
Centrosome 685 | 685
Extracellular matrix 670 | 670
Receptor complex 670 | 670
Synapse 656 | 656
Lysosome 600 | 600
Lytic vacuole 600 | 600
Endosomal part 554 | 554
Chromatin 552 | 552

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Cannabinoid receptor 2 CNR2 Tchem GPCR -2.45761 269.7 345
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Solute carrier family 22 member 8 SLC22A8 Tclin Transporter -2.40126 258.4 113
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417