Development Level

Tchem 21 | 1,598
Tbio 13 | 11,445

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal retina morphology 2 | 71
embryonic lethality prior to t... 2 | 278
increased neutrophil cell numb... 2 | 46
short tibia 2 | 97
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal coat appearance 1 | 31
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal startle reflex 1 | 15
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular vol... 1 | 79
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased spleen weight 1 | 10
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17

Disease

Carcinoma 27 | 11,493
ovarian cancer 24 | 8,520
glioblastoma 22 | 5,792
Cancer 21 | 2,499
atypical teratoid / rhabdoid tumor 20 | 5,112
medulloblastoma, large-cell 20 | 6,241
ependymoma 17 | 4,679
lung cancer 17 | 4,740
osteosarcoma 15 | 7,950
psoriasis 15 | 6,694
adult high grade glioma 14 | 3,801
Astrocytoma, Pilocytic 12 | 3,081
primitive neuroectodermal tumor 11 | 3,035
group 3 medulloblastoma 10 | 4,104
group 4 medulloblastoma 9 | 1,855
malignant mesothelioma 9 | 3,232
subependymal giant cell astrocytoma 9 | 2,287
Breast cancer 8 | 3,578
Kidney cancer 8 | 2,613
astrocytoma 8 | 1,146
juvenile dermatomyositis 8 | 1,187
Schizophrenia 7 | 1,160
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
pancreatic cancer 7 | 2,398
pediatric high grade glioma 7 | 1,064
Multiple myeloma 6 | 1,332
Pick disease 6 | 1,894
Rheumatoid arthritis 6 | 1,191
Vascular disease 6 | 319
adrenocortical carcinoma 6 | 1,428
oligodendroglioma 6 | 2,850
Carcinoma, Hepatocellular 5 | 228
Liver carcinoma 5 | 240
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
lung carcinoma 5 | 2,843
Alzheimer's disease 4 | 658
Breast Neoplasms 4 | 445
Byzanthine arch palate 4 | 194
Cell Transformation, Neoplastic 4 | 97
Chronic Lymphocytic Leukemia 4 | 262
Disease Progression 4 | 136
Endometriosis 4 | 540
Mammary Neoplasms 4 | 425
Melanoma 4 | 711
Neoplastic Cell Transformation 4 | 89
active ulcerative colitis 4 | 764
colon cancer 4 | 1,478
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
medulloblastoma 4 | 720
non-small cell lung cancer 4 | 2,890
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Adenocarcinoma of lung 3 | 142
Adenocarcinoma of lung (disorder) 3 | 60
Bipolar Disorder 3 | 666
Carcinoma, Squamous Cell 3 | 110
Cardiomegaly 3 | 116
Cleft Palate 3 | 271
Colonic Neoplasms 3 | 142
Curvature of spine 3 | 282
Epilepsy 3 | 792
Gaucher disease type 1 3 | 180
Hypertrophic Cardiomyopathy 3 | 117
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Liver neoplasms 3 | 130
Lung Neoplasms 3 | 232
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Mouth Neoplasms 3 | 55
Multiple Sclerosis 3 | 540
Neoplasm Metastasis 3 | 168
Orbital separation excessive 3 | 244
Osteoporosis 3 | 363
Parkinson's disease 3 | 392
Short stature 3 | 531
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
breast carcinoma 3 | 1,638
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
nasopharyngeal carcinoma 3 | 1,058
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109
Adenoma 2 | 167
Cocaine-Related Disorders 2 | 92
Neuroblastoma 2 | 80
Neurodegenerative disease 2 | 414
Pancreatic Neoplasm 2 | 85
Pancreatic Neoplasms 2 | 85

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678

Target Family

Kinase 13 | 634
Non-IDG 9 | 12,091
Transcription Factor 8 | 1,400
Enzyme 4 | 4,145

WikiPathways Pathway

p38 MAPK Signaling Pathway 34 | 34
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Heat shock protein beta-1 HSPB1 Tchem Non-IDG -2.97780 974.9 1992
DNA damage-inducible transcript 3 protein DDIT3 Tchem Transcription Factor -2.94434 736.0 704
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Transforming growth factor beta-2 TGFB2 Tbio Non-IDG -3.14427 1378.3 384
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334