Development Level

Tchem 15 | 1,598
Tclin 9 | 613
Tbio 7 | 11,445

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
enlarged heart 2 | 210
increased circulating alkaline... 2 | 122
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased B cell number 1 | 9
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 26 | 11,493
Cancer 25 | 2,499
ovarian cancer 23 | 8,520
psoriasis 21 | 6,694
Breast cancer 18 | 3,578
osteosarcoma 18 | 7,950
glioblastoma 17 | 5,792
lung cancer 16 | 4,740
medulloblastoma, large-cell 16 | 6,241
Prostatic Neoplasms 14 | 495
Schizophrenia 13 | 1,160
Breast Neoplasms 12 | 445
Kidney cancer 12 | 2,613
Mammary Neoplasms 12 | 425
atypical teratoid / rhabdoid tumor 12 | 5,112
Lung Neoplasms 11 | 232
group 3 medulloblastoma 11 | 4,104
malignant mesothelioma 11 | 3,232
subependymal giant cell astrocytoma 11 | 2,287
Intellectual disability 10 | 1,016
Multiple myeloma 10 | 1,332
Carcinoma, Hepatocellular 9 | 228
Dull intelligence 9 | 645
Epilepsy 9 | 792
Liver carcinoma 9 | 240
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Poor school performance 9 | 645
Vascular disease 9 | 319
ependymoma 9 | 4,679
oligodendroglioma 9 | 2,850
Acquired scoliosis 8 | 281
Adenocarcinoma 8 | 122
Adenoma 8 | 167
Colonic Neoplasms 8 | 142
Curvature of spine 8 | 282
Downward slant of palpebral fissure 8 | 158
Seizures 8 | 596
Short stature 8 | 531
Stomach Neoplasms 8 | 300
Strabismus 8 | 270
pancreatic cancer 8 | 2,398
pituitary cancer 8 | 1,972
Blepharoptosis 7 | 231
Byzanthine arch palate 7 | 194
Cognitive delay 7 | 608
Concave bridge of nose 7 | 195
Congenital Epicanthus 7 | 177
Cryptorchidism 7 | 296
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Endometrial cancer 7 | 311
Frontal bossing 7 | 157
Global developmental delay 7 | 608
High forehead 7 | 102
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Orbital separation excessive 7 | 244
Pectus excavatum 7 | 100
Tall forehead 7 | 102
astrocytoma 7 | 1,146
breast carcinoma 7 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
juvenile dermatomyositis 7 | 1,187
primitive neuroectodermal tumor 7 | 3,035
tuberculosis 7 | 2,010
Big calvaria 6 | 147
Brain Ischemia 6 | 110
Colorectal Neoplasms 6 | 243
Depressive disorder 6 | 409
Feeding difficulties in infancy 6 | 175
Immune system cancer 6 | 140
Increased head circumference 6 | 147
Increased size of cranium 6 | 147
Increased size of skull 6 | 147
Liver neoplasms 6 | 130
Low posterior hairline 6 | 52
Lymphoid leukemia 6 | 160
Melanoma 6 | 711
Ovarian Neoplasms 6 | 102
Pick disease 6 | 1,894
Renal Cell Carcinoma 6 | 214
Rheumatoid arthritis 6 | 1,191
Skin hyperelastic 6 | 32
Sparse hair 6 | 59
Splenomegaly 6 | 190
Squamous cell carcinoma 6 | 129
Thin, sparse hair 6 | 59
Ventricular Septal Defects 6 | 119
astrocytic glioma 6 | 2,597
diabetes mellitus 6 | 1,728
ductal carcinoma in situ 6 | 1,745
hepatocellular carcinoma 6 | 547
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Urinary Tract 30 | 16,678
Cardiovascular System 29 | 15,192

Target Family

Kinase 10 | 634
Non-IDG 8 | 12,091
Enzyme 6 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

WikiPathways Pathway

miRNA regulation of prostate c... 31 | 31
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
Androgen receptor AR Tclin Nuclear Receptor -3.82874 7137.7 1609
Bcl2-associated agonist of cell death BAD Tchem Non-IDG -2.08893 103.4 2565
Platelet-derived growth factor subunit A PDGFA Tchem Non-IDG -2.74845 537.8 341
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298