Development Level

Tbio 36 | 10,625
Tchem 31 | 1,890
Tclin 3 | 602
Tdark 3 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 4 | 148
abnormal embryo size 2 | 112
embryonic lethality prior to t... 2 | 187
increased circulating sodium l... 2 | 71
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal pharyngeal arch morph... 1 | 2
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
embryonic growth retardation 1 | 28
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating HDL chol... 1 | 63
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased mean corpuscular hem... 1 | 93
male infertility 1 | 62
microphthalmia 1 | 15
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
urinary bladder obstruction 1 | 2

Disease

Cancer 58 | 2,346
ovarian cancer 49 | 8,484
medulloblastoma, large-cell 43 | 6,234
lung cancer 41 | 4,466
osteosarcoma 41 | 7,933
glioblastoma 39 | 5,572
psoriasis 38 | 6,685
malignant mesothelioma 32 | 3,162
atypical teratoid / rhabdoid tumor 29 | 4,369
Breast cancer 27 | 3,094
pediatric high grade glioma 27 | 2,712
primitive neuroectodermal tumor 26 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
group 3 medulloblastoma 23 | 2,254
non-small cell lung cancer 23 | 2,798
colon cancer 20 | 1,475
lung adenocarcinoma 20 | 2,713
adrenocortical carcinoma 19 | 1,427
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
invasive ductal carcinoma 17 | 2,950
nasopharyngeal carcinoma 17 | 1,056
pancreatic cancer 17 | 2,300
Mammary Neoplasms 16 | 410
Prostatic Neoplasms 15 | 471
oligodendroglioma 15 | 2,849
Ataxia telangiectasia 14 | 31
Carcinoma 14 | 2,147
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
pilocytic astrocytoma 14 | 3,086
posterior fossa group A ependymoma 14 | 1,511
ulcerative colitis 14 | 2,087
Nijmegen breakage syndrome 13 | 23
astrocytoma 13 | 1,493
atypical teratoid/rhabdoid tumor 12 | 1,095
subependymal giant cell astrocytoma 12 | 2,287
Endometriosis 11 | 535
Liver carcinoma 11 | 217
Stomach Neoplasms 11 | 282
acute quadriplegic myopathy 11 | 1,157
tuberculosis 11 | 1,557
Atopic dermatitis 10 | 944
breast carcinoma 10 | 1,614
ependymoma 10 | 2,514
juvenile dermatomyositis 10 | 1,189
Lung Neoplasms 9 | 171
lung carcinoma 9 | 2,844
medulloblastoma 9 | 1,524
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,271
sonic hedgehog group medulloblastoma 9 | 1,482
Bladder Neoplasm 8 | 109
Chronic Lymphocytic Leukemia 8 | 242
Neoplastic Syndromes, Hereditary 8 | 48
Peripheral Neuropathy 8 | 303
Waldenstrons macroglobulinemia 8 | 765
group 4 medulloblastoma 8 | 1,875
Adenoid Cystic Carcinoma 7 | 99
Alzheimer's disease 7 | 644
Colonic Neoplasms 7 | 126
Esophageal Neoplasms 7 | 67
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
IGA Glomerulonephritis 7 | 454
Microcephaly 7 | 149
Pancreatic Neoplasm 7 | 79
Pick disease 7 | 1,893
Toxic encephalopathy 7 | 131
cystic fibrosis 7 | 1,665
diabetes mellitus 7 | 1,663
Brain Ischemia 6 | 87
Melanoma 6 | 261
Multiple myeloma 6 | 1,327
adult high grade glioma 6 | 2,148
astrocytic glioma 6 | 2,241
gastric carcinoma 6 | 832
ovarian neoplasm 6 | 97
primary Sjogren syndrome 6 | 789
Adenoma 5 | 165
Amyotrophic Lateral Sclerosis 5 | 431
Bloom syndrome 5 | 30
Liver Neoplasms, Experimental 5 | 48
Mammary Neoplasms, Experimental 5 | 150
Multiple Sclerosis 5 | 498
Neoplastic Cell Transformation 5 | 81
Parkinson's disease 5 | 364
Polycystic Ovary Syndrome 5 | 332
Precursor Cell Lymphoblastic Leukemia Lymphoma 5 | 42
Seckel syndrome 5 | 34
Squamous cell carcinoma of esophagus 5 | 82
Vascular disease 5 | 281
Werner syndrome 5 | 29
acute myeloid leukemia 5 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
cutaneous lupus erythematosus 5 | 1,056
dermatomyositis 5 | 933
esophageal adenocarcinoma 5 | 737
hepatocellular carcinoma 5 | 532
interstitial cystitis 5 | 2,299
non-small cell lung carcinoma 5 | 413
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795

Tissue

Blood and immune system 72 | 17,995
Digestive Tract 72 | 18,473
Female tissues 72 | 18,647
Liver and Pancreas 72 | 18,136
Male tissues 72 | 17,969
Nervous System 72 | 18,561
Respiratory system 72 | 17,484
Urinary Tract 72 | 18,444
Cardiovascular System 71 | 17,958
Endocrine System 71 | 18,512
Skin and soft tissues 71 | 18,115

Target Family

Non-IDG 46 | 11,971
Kinase 13 | 634
Enzyme 10 | 4,146
Transcription Factor 4 | 1,400

WikiPathways Pathway

miRNA Regulation of DNA Damage... 73 | 73
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 257 | 257
Circadian rythm related genes 200 | 200
Integrated Pancreatic Cancer P... 192 | 192
Focal Adhesion 190 | 190
Metapathway biotransformation 172 | 172
MAPK Signaling Pathway 167 | 167
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
Myometrial Relaxation and Cont... 157 | 157
Sudden Infant Death Syndrome (... 157 | 157
Allograft Rejection 156 | 156
Integrated Breast Cancer Pathw... 152 | 152
Calcium Regulation in the Card... 150 | 150
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Signaling Pathways in Glioblas... 83 | 83
MicroRNAs in cardiomyocyte hyp... 82 | 82
Alzheimers Disease 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Arrhythmogenic Right Ventricul... 74 | 74
Peptide GPCRs 74 | 74
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Wnt Signaling Pathway 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
IL-1 signaling pathway 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Copper homeostasis 54 | 54
ErbB Signaling Pathway 54 | 54
IL-4 Signaling Pathway 54 | 54
Interferon type I signaling pa... 54 | 54
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54
Apoptosis-related network due ... 53 | 53
Cardiac Hypertrophic Response 53 | 53
Cardiac Progenitor Differentia... 53 | 53
Synaptic Vesicle Pathway 51 | 51
Translation Factors 51 | 51
Wnt Signaling Pathway Netpath 51 | 51

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.95631 90.0 412
G1/S-specific cyclin-D1 CCND1 Tchem Non-IDG -3.77851 5447.1 1111
Cyclin-G1 CCNG1 Tbio Non-IDG -1.92472 83.2 213
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Cytochrome c CYCS Tbio Non-IDG -3.73952 4771.4 630