Development Level

Tbio 41 | 11,651
Tchem 26 | 1,388
Tclin 3 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
hyperactivity 3 | 148
increased mean corpuscular hem... 3 | 96
preweaning lethality, incomple... 3 | 499
abnormal blood vessel morpholo... 2 | 5
abnormal heart morphology 2 | 162
abnormal pharyngeal arch morph... 2 | 8
decreased mean corpuscular vol... 2 | 79
embryonic growth retardation 2 | 106
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 36
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased aggression 1 | 4
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
male infertility 1 | 123
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
urinary bladder obstruction 1 | 4

Disease

Cancer 58 | 2,499
ovarian cancer 51 | 8,520
Carcinoma 43 | 11,493
medulloblastoma, large-cell 43 | 6,241
lung cancer 42 | 4,740
glioblastoma 41 | 5,792
osteosarcoma 41 | 7,950
atypical teratoid / rhabdoid tumor 40 | 5,112
psoriasis 38 | 6,694
group 3 medulloblastoma 36 | 4,104
malignant mesothelioma 33 | 3,232
Breast cancer 29 | 3,578
primitive neuroectodermal tumor 26 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
ependymoma 24 | 4,679
non-small cell lung cancer 23 | 2,890
adult high grade glioma 22 | 3,801
colon cancer 20 | 1,478
lung adenocarcinoma 20 | 2,716
adrenocortical carcinoma 19 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
pancreatic cancer 18 | 2,398
Prostatic Neoplasms 17 | 495
invasive ductal carcinoma 17 | 2,951
nasopharyngeal carcinoma 17 | 1,058
Breast Neoplasms 16 | 445
Kidney cancer 16 | 2,613
Mammary Neoplasms 16 | 425
Ataxia telangiectasia 15 | 34
oligodendroglioma 15 | 2,850
Astrocytoma, Pilocytic 14 | 3,081
Autosomal recessive predisposition 14 | 1,442
Schizophrenia 14 | 1,160
breast carcinoma 14 | 1,638
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Nijmegen breakage syndrome 13 | 24
ulcerative colitis 13 | 1,819
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
subependymal giant cell astrocytoma 12 | 2,287
tuberculosis 12 | 2,010
Endometriosis 11 | 540
Lung Neoplasms 11 | 232
Short stature 11 | 531
Stomach Neoplasms 11 | 300
acute quadriplegic myopathy 11 | 1,158
pediatric high grade glioma 11 | 1,064
Atopic dermatitis 10 | 952
Small head 10 | 374
astrocytoma 10 | 1,146
juvenile dermatomyositis 10 | 1,187
Colonic Neoplasms 9 | 142
Dull intelligence 9 | 645
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Pancreatic Neoplasm 9 | 85
Poor school performance 9 | 645
astrocytic glioma 9 | 2,597
hepatocellular carcinoma 9 | 547
lung carcinoma 9 | 2,843
pituitary cancer 9 | 1,972
Bladder Neoplasm 8 | 112
Melanoma 8 | 711
Urinary Bladder Neoplasms 8 | 114
Waldenstrons macroglobulinemia 8 | 765
Xeroderma pigmentosum 8 | 43
medulloblastoma 8 | 720
primary pancreatic ductal adenocarcinoma 8 | 1,109
Adenoid Cystic Carcinoma 7 | 99
Alzheimer's disease 7 | 658
Carcinoma, Adenoid Cystic 7 | 99
Carcinoma, Squamous Cell 7 | 110
Chromosome Breakage 7 | 36
Esophageal Neoplasms 7 | 69
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Liver Neoplasms, Experimental 7 | 59
Microcephaly 7 | 166
Pancreatic Neoplasms 7 | 85
Pick disease 7 | 1,894
Polycystic ovary syndrome 7 | 360
Squamous cell carcinoma 7 | 129
Toxic encephalopathy 7 | 141
Vascular disease 7 | 319
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
Brain Ischemia 6 | 110
Chronic Lymphocytic Leukemia 6 | 262
Cognitive delay 6 | 608
Epilepsy 6 | 792
Global developmental delay 6 | 608
Immune system cancer 6 | 140
Mental and motor retardation 6 | 608
Multiple myeloma 6 | 1,332
Precursor Cell Lymphoblastic Leukemia-Lymphoma 6 | 49
acute myeloid leukemia 6 | 783
gastric carcinoma 6 | 807
primary Sjogren syndrome 6 | 735

Tissue

Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Male tissues 71 | 17,142
Respiratory system 71 | 16,393
Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Liver and Pancreas 70 | 16,750
Skin and soft tissues 70 | 17,230
Urinary Tract 70 | 16,678
Nervous System 69 | 16,725
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 46 | 12,091
Kinase 13 | 634
Enzyme 10 | 4,145
Transcription Factor 4 | 1,400

WikiPathways Pathway

miRNA Regulation of DNA Damage... 73 | 73
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
mRNA Processing 125 | 125
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 20 homolog B CDC20B Tdark Non-IDG -0.47873 2.05 122
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
BH3-interacting domain death agonist BID Tbio Non-IDG -1.85313 58.9 981
p53-regulated apoptosis-inducing protein 1 TP53AIP1 Tbio Non-IDG -1.34343 17.8 97
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.06393 1238.4 694
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542