Development Level

Tbio 108 | 11,445
Tchem 11 | 1,598
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 25 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
decreased neutrophil cell numb... 4 | 42
increased mean corpuscular vol... 3 | 92
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased circulating calcium ... 2 | 36
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating creatini... 2 | 38
increased circulating serum al... 2 | 22
increased fasted circulating g... 2 | 76
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal kidney morphology 1 | 65
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
absent spleen 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased granulocyte number 1 | 6
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged seminal vesicle 1 | 10
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
pallor 1 | 34
prenatal lethality 1 | 28
small adrenal glands 1 | 16
small testis 1 | 58
small thymus 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39

Disease

ovarian cancer 93 | 8,520
Carcinoma 91 | 11,493
osteosarcoma 71 | 7,950
medulloblastoma, large-cell 60 | 6,241
psoriasis 52 | 6,694
group 3 medulloblastoma 50 | 4,104
glioblastoma 45 | 5,792
lung cancer 45 | 4,740
ependymoma 43 | 4,679
Multiple myeloma 40 | 1,332
atypical teratoid / rhabdoid tumor 35 | 5,112
acute quadriplegic myopathy 33 | 1,158
oligodendroglioma 32 | 2,850
primitive neuroectodermal tumor 32 | 3,035
Waldenstrons macroglobulinemia 29 | 765
Pick disease 28 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
astrocytic glioma 27 | 2,597
dermatomyositis 25 | 966
diabetes mellitus 24 | 1,728
Breast cancer 22 | 3,578
Kidney cancer 20 | 2,613
astrocytoma 19 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
malignant mesothelioma 19 | 3,232
progressive supranuclear palsy 19 | 676
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
non-small cell lung cancer 17 | 2,890
lung adenocarcinoma 16 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Cancer 14 | 2,499
adult high grade glioma 14 | 3,801
Intellectual disability 13 | 1,016
acute myeloid leukemia 13 | 783
subependymal giant cell astrocytoma 13 | 2,287
Gaucher disease type 1 12 | 180
group 4 medulloblastoma 12 | 1,855
juvenile dermatomyositis 12 | 1,187
pediatric high grade glioma 12 | 1,064
Conductive hearing loss 9 | 123
aldosterone-producing adenoma 9 | 665
pituitary cancer 9 | 1,972
Amyotrophic lateral sclerosis 8 | 451
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
atypical teratoid/rhabdoid tumor 8 | 357
colon cancer 8 | 1,478
relapsing-remitting multiple sclerosis 8 | 18
HIV Infections 7 | 102
Rheumatoid arthritis 7 | 1,191
cystic fibrosis 7 | 1,696
hepatocellular carcinoma 7 | 547
nasopharyngeal carcinoma 7 | 1,058
tuberculosis and treatment for 6 months 7 | 409
Alzheimer's disease 6 | 658
Anteverted nostril 6 | 191
Astrocytoma, Pilocytic 6 | 3,081
breast carcinoma 6 | 1,638
invasive ductal carcinoma 6 | 2,951
non primary Sjogren syndrome sicca 6 | 891
pancreatic cancer 6 | 2,398
Broad flat nasal bridge 5 | 236
Congenital hypoplasia of penis 5 | 176
Endometrial cancer 5 | 311
Hypoplastic mandible condyle 5 | 275
Keratoconus 5 | 113
Mammary Neoplasms, Experimental 5 | 154
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Nasal bridge wide 5 | 236
Nystagmus 5 | 317
Obesity 5 | 678
Ophthalmoplegia 5 | 106
Polycystic ovary syndrome 5 | 360
Renal Cell Carcinoma 5 | 214
Retinitis Pigmentosa 5 | 226
Schizophrenia 5 | 1,160
Sensorineural Hearing Loss (disorder) 5 | 284
Small head 5 | 374
adrenocortical carcinoma 5 | 1,428
sonic hedgehog group medulloblastoma 5 | 467
Absent auditory canals 4 | 23
Absent external auditory canals 4 | 23
Atresia of the external auditory canal 4 | 23
Atretic auditory canal 4 | 23
Autosomal recessive predisposition 4 | 1,442
Blind Vision 4 | 111
Blindness, Legal 4 | 110
Byzanthine arch palate 4 | 194
Crohn's disease 4 | 321
Glaucoma 4 | 239
Immune system cancer 4 | 140
Myopathy 4 | 185
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
primary pancreatic ductal adenocarcinoma 4 | 1,109
spina bifida 4 | 1,074
tuberculosis 4 | 2,010

Tissue

Blood and immune system 125 | 16,909
Cardiovascular System 125 | 15,192
Digestive Tract 125 | 17,369
Endocrine System 125 | 18,159
Female tissues 125 | 17,400
Liver and Pancreas 125 | 16,750
Male tissues 125 | 17,142
Nervous System 125 | 16,725
Respiratory system 125 | 16,393
Skin and soft tissues 125 | 17,230
Urinary Tract 125 | 16,678

Target Family

Non-IDG 98 | 12,091
Enzyme 15 | 4,145
Kinase 8 | 634
Epigenetic 3 | 242
Transcription Factor 1 | 1,400

WikiPathways Pathway

mRNA Processing 125 | 125
PI3K-Akt Signaling Pathway 338 | 338
Focal Adhesion-PI3K-Akt-mTOR-s... 303 | 303
GPCRs, Class A Rhodopsin-like 258 | 258
MAPK Signaling Pathway 245 | 245
VEGFA-VEGFR2 Signaling Pathway 235 | 235
Focal Adhesion 206 | 206
Circadian rythm related genes 200 | 200
Vitamin D Receptor Pathway 196 | 196
Ras Signaling 182 | 182
Metapathway biotransformation ... 172 | 172
Allograft Rejection 168 | 168
Chemokine signaling pathway 164 | 164
EGF/EGFR Signaling Pathway 162 | 162
Insulin Signaling 160 | 160
EMT transition in Colorectal C... 159 | 159
Myometrial Relaxation and Cont... 159 | 159
Sudden Infant Death Syndrome (... 157 | 157
Calcium Regulation in the Card... 152 | 152
Integrated Breast Cancer Pathw... 152 | 152
Regulation of Actin Cytoskelet... 149 | 149
Mesodermal Commitment Pathway 147 | 147
Brain-Derived Neurotrophic Fac... 144 | 144
NRF2 pathway 143 | 143
Endoderm Differentiation 141 | 141
Ectoderm Differentiation 138 | 138
Regulation of toll-like recept... 138 | 138
Wnt Signaling Pathway 135 | 135
Angiopoietin Like Protein 8 Re... 132 | 132
TGF-beta Signaling Pathway 132 | 132
Adipogenesis 130 | 130
Proteasome Degradation 129 | 129
ESC Pluripotency Pathways 116 | 116
Spinal Cord Injury 116 | 116
DNA Damage Response (only ATM ... 112 | 112
Senescence and Autophagy in Ca... 106 | 106
Cell Cycle 104 | 104
Electron Transport Chain 103 | 103
Neural Crest Differentiation 101 | 101
Toll-like Receptor Signaling P... 101 | 101
Wnt Signaling Pathway and Plur... 101 | 101
Integrin-mediated Cell Adhesio... 100 | 100
B Cell Receptor Signaling Path... 97 | 97
Corticotropin-releasing hormon... 95 | 95
G Protein Signaling Pathways 94 | 94
Amino Acid metabolism 92 | 92
Apoptosis Modulation and Signa... 92 | 92
GPCRs, Other 92 | 92
TNF alpha Signaling Pathway 92 | 92
T-Cell antigen Receptor (TCR) ... 90 | 90
Androgen receptor signaling pa... 89 | 89
Cytoplasmic Ribosomal Proteins 89 | 89
Retinoblastoma (RB) in Cancer 87 | 87
Apoptosis 86 | 86
Selenium Micronutrient Network 85 | 85
Pyrimidine metabolism 84 | 84
Signaling Pathways in Glioblas... 83 | 83
Alzheimers Disease 82 | 82
MicroRNAs in cardiomyocyte hyp... 82 | 82
DNA IR-damage and cellular res... 80 | 80
Notch Signaling Pathway 79 | 79
Leptin signaling pathway 76 | 76
Prolactin Signaling Pathway 76 | 76
Peptide GPCRs 75 | 75
Arrhythmogenic Right Ventricul... 74 | 74
Chromosomal and microsatellite... 74 | 74
miRNA Regulation of DNA Damage... 73 | 73
Primary Focal Segmental Glomer... 72 | 72
Type II interferon signaling (... 71 | 71
DNA Damage Response 69 | 69
G1 to S cell cycle control 69 | 69
Parkin-Ubiquitin Proteasomal S... 69 | 69
Sterol Regulatory Element-Bind... 69 | 69
AMP-activated Protein Kinase (... 68 | 68
Human Thyroid Stimulating Horm... 68 | 68
PPAR signaling pathway 67 | 67
Rac1/Pak1/p38/MMP-2 pathway 67 | 67
AGE/RAGE pathway 66 | 66
Association Between Physico-Ch... 66 | 66
Folate Metabolism 65 | 65
Oncostatin M Signaling Pathway 65 | 65
Lung fibrosis 64 | 64
Pathways Affected in Adenoid C... 64 | 64
Endometrial cancer 63 | 63
Endochondral Ossification 62 | 62
MECP2 and Associated Rett Synd... 62 | 62
Oxidation by Cytochrome P450 62 | 62
TYROBP Causal Network 61 | 61
Oxidative phosphorylation 60 | 60
T-Cell antigen Receptor (TCR) ... 60 | 60
Complement and Coagulation Cas... 59 | 59
Kit receptor signaling pathway 59 | 59
RIG-I-like Receptor Signaling 59 | 59
Preimplantation Embryo 58 | 58
DNA IR-Double Strand Breaks (D... 56 | 56
IL-1 signaling pathway 55 | 55
MET in type 1 papillary renal ... 55 | 55
RANKL/RANK (Receptor activator... 55 | 55
Pathogenic Escherichia coli in... 54 | 54
TGF-beta Receptor Signaling 54 | 54

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cleavage and polyadenylation specificity factor subunit 3 CPSF3 Tbio Non-IDG -1.47182 27.3 190
Polypyrimidine tract-binding protein 2 PTBP2 Tbio Non-IDG -2.05261 113.3 151
Heterogeneous nuclear ribonucleoprotein M HNRNPM Tbio Non-IDG -1.64443 45.9 331
Serine/threonine-protein kinase PRP4 homolog PRPF4B Tchem Kinase -1.17233 14.7 144
Splicing factor 3B subunit 2 SF3B2 Tbio Non-IDG -1.32229 20.7 163
Heterogeneous nuclear ribonucleoprotein A/B HNRNPAB Tbio Non-IDG -1.15839 12.5 96
U6 snRNA-associated Sm-like protein LSm2 LSM2 Tbio Non-IDG -1.40226 23.0 121
N6-adenosine-methyltransferase catalytic subunit METTL3 Tbio Enzyme -1.76174 60.5 94
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Pre-mRNA-splicing factor 18 PRPF18 Tbio Non-IDG -1.36183 19.8 84